Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 DHFR 4件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
2 DHODH 3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors D00749 Leflunomide 12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
3 DHODH 3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors D10172 Teriflunomide 3件: 13, 25, 26
4 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis D08682 Warfarin 11件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91
5 DHFR2 4件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
6 ALAS1 4件: Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis of cofactors D10003 Hemin 1件: 254
7 ALAS1 4件: Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis of cofactors D11702 Givosiran 1件: 254
8 ALAS2 4件: Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis of cofactors D10003 Hemin 1件: 254
9 ALPL 4件: Thiamine metabolism, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors D10595 Asfotase alfa 1件: 172
10 GUSB 7件: Pentose and glucuronate interconversions, Glycosaminoglycan degradation, Porphyrin metabolism, Drug metabolism - other enzymes, Metabolic pathways, Biosynthesis of cofactors, Lysosome D11004 Vestronidase alfa 1件: 19
11 HPD 5件: Ubiquinone and other terpenoid-quinone biosynthesis, Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways, Biosynthesis of cofactors D05177 Nitisinone 3件: 6, 164, 241
12 VKORC1 3件: Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofactors D08354 Phenindione 1件: 65
13 VKORC1 3件: Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofactors D08682 Warfarin 11件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91