Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 MTOR 1件: Type II diabetes mellitus D00753 Sirolimus 40件: 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331
2 MTOR 1件: Type II diabetes mellitus D02714 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277
3 MTOR 1件: Type II diabetes mellitus D06068 Temsirolimus 1件: 13
4 INSR 1件: Type II diabetes mellitus D03230 Insulin human 2件: 96, 156
5 INSR 1件: Type II diabetes mellitus D03250 Insulin glargine 1件: 299
6 INSR 1件: Type II diabetes mellitus D04539 Insulin detemir 1件: 299
7 KCNJ11 1件: Type II diabetes mellitus D00294 Diazoxide 2件: 13, 193
8 KCNJ11 1件: Type II diabetes mellitus D00418 Minoxidil 1件: 179
9 KCNJ11 1件: Type II diabetes mellitus D00594 Repaglinide 4件: 6, 21, 46, 299
10 KCNJ11 1件: Type II diabetes mellitus D02910 Amiodarone 2件: 28, 127
11 PIK3CA 4件: VEGF signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11011 Alpelisib 1件: 138
12 PIK3CA 4件: VEGF signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
13 PIK3CB 4件: VEGF signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
14 PIK3CD 4件: VEGF signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
15 PIK3CD 4件: VEGF signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11437 Parsaclisib 3件: 35, 53, 61
16 PRKCD 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D09671 Sotrastaurin 1件: 97
17 PRKCE 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D09671 Sotrastaurin 1件: 97
18 ABCC8 1件: Type II diabetes mellitus D00294 Diazoxide 2件: 13, 193
19 ABCC8 1件: Type II diabetes mellitus D00418 Minoxidil 1件: 179
20 ABCC8 1件: Type II diabetes mellitus D00594 Repaglinide 4件: 6, 21, 46, 299
21 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D00742 Etanercept 16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
22 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D00754 Thalidomide 20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
23 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
24 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D02597 Adalimumab 17件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
25 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D02598 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
26 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D03441 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271
27 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D04358 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271
28 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D04687 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331
29 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D05393 Pegsunercept 1件: 46
30 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D08976 Pomalidomide 5件: 28, 51, 85, 227, 331
31 TNF 3件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Yersinia infection D09944 Ozoralizumab 1件: 46
32 CACNA1B 1件: Type II diabetes mellitus D01173 Cilnidipine 1件: 67
33 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D00349 Isradipine 1件: 6
34 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D00437 Nifedipine 2件: 50, 81
35 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
36 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D01173 Cilnidipine 1件: 67
37 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D01908 Nilvadipine 1件: 90
38 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D02356 Verapamil 4件: 58, 96, 140, 167
39 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D07450 Amlodipine 4件: 13, 51, 67, 298
40 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D07845 Diltiazem 3件: 51, 58, 86
41 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D08270 Nicardipine 2件: 70, 86
42 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D08340 Perhexiline 2件: 58, 272
43 CACNA1C 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D08441 Propiverine 1件: 226
44 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D00349 Isradipine 1件: 6
45 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D00437 Nifedipine 2件: 50, 81
46 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
47 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D01173 Cilnidipine 1件: 67
48 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D01908 Nilvadipine 1件: 90
49 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D02356 Verapamil 4件: 58, 96, 140, 167
50 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D07450 Amlodipine 4件: 13, 51, 67, 298
51 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D07845 Diltiazem 3件: 51, 58, 86
52 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D08270 Nicardipine 2件: 70, 86
53 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D08340 Perhexiline 2件: 58, 272
54 CACNA1D 2件: Vascular smooth muscle contraction, Type II diabetes mellitus D08441 Propiverine 1件: 226
55 CACNA1G 1件: Type II diabetes mellitus D00399 Valproic acid 14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
56 CACNA1G 1件: Type II diabetes mellitus D00538 Zonisamide 1件: 6
57 CACNA1G 1件: Type II diabetes mellitus D07971 Flunarizine 1件: 149