Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 MAPK14 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
2 MAPK14 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
3 IFNA1 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
4 IFNA1 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
5 IFNA2 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
6 IFNA2 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
7 IFNA4 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
8 IFNA4 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
9 IFNA5 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
10 IFNA5 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
11 IFNA6 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
12 IFNA6 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
13 IFNA7 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
14 IFNA7 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
15 IFNA8 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
16 IFNA8 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
17 IFNA10 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
18 IFNA10 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
19 IFNA13 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
20 IFNA13 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
21 IFNA14 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
22 IFNA14 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
23 IFNA16 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
24 IFNA16 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
25 IFNA17 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
26 IFNA17 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
27 IFNA21 2件: Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
28 IFNA21 2件: Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
29 IFNAR1 1件: Toll-like receptor signaling pathway D00745 Interferon alfa-2a 1件: 56
30 IFNAR1 1件: Toll-like receptor signaling pathway D00746 Interferon beta-1b 1件: 13
31 IFNAR1 1件: Toll-like receptor signaling pathway D02745 Interferon alfa-2b 2件: 25, 34
32 IFNAR1 1件: Toll-like receptor signaling pathway D03305 Interferon alfa 6件: 13, 25, 26, 28, 56, 96
33 IFNAR1 1件: Toll-like receptor signaling pathway D04554 Interferon beta-1a 4件: 13, 26, 96, 97
34 IFNAR1 1件: Toll-like receptor signaling pathway D10483 Peginterferon beta-1a 1件: 13
35 IFNAR1 1件: Toll-like receptor signaling pathway D11082 Anifrolumab 3件: 46, 49, 53
36 IFNAR2 1件: Toll-like receptor signaling pathway D00745 Interferon alfa-2a 1件: 56
37 IFNAR2 1件: Toll-like receptor signaling pathway D00746 Interferon beta-1b 1件: 13
38 IFNAR2 1件: Toll-like receptor signaling pathway D02745 Interferon alfa-2b 2件: 25, 34
39 IFNAR2 1件: Toll-like receptor signaling pathway D03305 Interferon alfa 6件: 13, 25, 26, 28, 56, 96
40 IFNAR2 1件: Toll-like receptor signaling pathway D04554 Interferon beta-1a 4件: 13, 26, 96, 97
41 IFNAR2 1件: Toll-like receptor signaling pathway D10483 Peginterferon beta-1a 1件: 13
42 IFNAR2 1件: Toll-like receptor signaling pathway D11082 Anifrolumab 3件: 46, 49, 53
43 IL1B 4件: Toll-like receptor signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
44 IL1B 4件: Toll-like receptor signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D06635 Rilonacept 4件: 51, 106, 107, 266
45 IL1B 4件: Toll-like receptor signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D09315 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
46 IL1B 4件: Toll-like receptor signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D09911 Gevokizumab 4件: 41, 50, 56, 269
47 IL6 5件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
48 IL6 5件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D08976 Pomalidomide 5件: 28, 51, 85, 227, 331
49 IL6 5件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D09669 Siltuximab 2件: 28, 331
50 IL6 5件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D10080 Sirukumab 2件: 41, 46
51 IL6 5件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D12487 Olokizumab 2件: 46, 96
52 IL12A 4件: Toll-like receptor signaling pathway, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab 16件: 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
53 IL12B 4件: Toll-like receptor signaling pathway, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab 16件: 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
54 NFKB1 6件: Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D01146 Iguratimod 5件: 46, 51, 53, 271, 300
55 TLR7 1件: Toll-like receptor signaling pathway D02500 Imiquimod 2件: 34, 51
56 PIK3CA 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11011 Alpelisib 1件: 138
57 PIK3CA 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
58 PIK3CB 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
59 PIK3CD 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
60 PIK3CD 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11437 Parsaclisib 3件: 35, 53, 61
61 TLR9 2件: Toll-like receptor signaling pathway, Tuberculosis D12275 Cobitolimod 1件: 97
62 MAPK11 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
63 MAPK11 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
64 MAPK13 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
65 MAPK13 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
66 MAP2K1 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D09666 Selumetinib 1件: 34
67 MAP2K1 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10175 Trametinib 4件: 2, 34, 279, 280
68 MAP2K1 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10405 Cobimetinib 1件: 280
69 MAP2K1 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10604 Binimetinib 1件: 34
70 MAP2K1 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D11675 Mirdametinib 1件: 34
71 MAP2K2 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D09666 Selumetinib 1件: 34
72 MAP2K2 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10175 Trametinib 4件: 2, 34, 279, 280
73 MAP2K2 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10405 Cobimetinib 1件: 280
74 MAP2K2 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10604 Binimetinib 1件: 34
75 MAP2K2 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D11675 Mirdametinib 1件: 34
76 RELA 6件: Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D12181 Edasalonexent 1件: 113
77 MAPK12 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
78 MAPK12 5件: VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
79 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D00742 Etanercept 16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
80 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D00754 Thalidomide 20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
81 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
82 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D02597 Adalimumab 17件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
83 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D02598 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
84 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D03441 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271
85 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D04358 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271
86 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D04687 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331
87 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D05393 Pegsunercept 1件: 46
88 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D08976 Pomalidomide 5件: 28, 51, 85, 227, 331
89 TNF 7件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D09944 Ozoralizumab 1件: 46
90 CD80 4件: Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis D03203 Abatacept 26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
91 CD80 4件: Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis D03222 Belatacept 1件: 46
92 CD86 5件: Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Transcriptional misregulation in cancer, Viral myocarditis D03203 Abatacept 26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
93 CD86 5件: Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Transcriptional misregulation in cancer, Viral myocarditis D03222 Belatacept 1件: 46
94 CD40 4件: Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Viral myocarditis D11357 Bleselumab 1件: 222
95 CD40 4件: Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Viral myocarditis D11597 Ravagalimab 2件: 53, 97
96 CD40 4件: Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Viral myocarditis D11610 Iscalimab 2件: 49, 53