Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 CFTR 4件: Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D09916 Ivacaftor 1件: 299
2 CFTR 4件: Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D10134 Lumacaftor 1件: 299
3 CFTR 4件: Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11041 Tezacaftor 1件: 299
4 CFTR 4件: Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11423 Deutivacaftor 1件: 299
5 CFTR 4件: Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11507 Elexacaftor 1件: 299
6 CFTR 4件: Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11724 Galicaftor 1件: 299
7 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00113 Atropine 2件: 2, 299
8 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00138 Scopolamine 1件: 2
9 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00270 Chlorpromazine 1件: 254
10 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00397 Tropicamide 1件: 6
11 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00465 Oxybutynin 3件: 6, 13, 53
12 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00525 Pilocarpine 3件: 6, 53, 299
13 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00646 Tolterodine 2件: 17, 53
14 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D03654 Darifenacin 2件: 6, 13
15 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D07226 Fesoterodine 1件: 6
16 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D07667 Cevimeline 1件: 53
17 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08441 Propiverine 1件: 226
18 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08522 Solifenacin 3件: 6, 13, 53
19 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08638 Trihexyphenidyl 2件: 5, 6
20 CHRM3 8件: Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D11383 Blarcamesine 1件: 156
21 HRH2 2件: Neuroactive ligand-receptor interaction, Gastric acid secretion D00295 Cimetidine 2件: 2, 254
22 HRH2 2件: Neuroactive ligand-receptor interaction, Gastric acid secretion D00318 Famotidine 6件: 6, 46, 61, 86, 98, 107
23 HRH2 2件: Neuroactive ligand-receptor interaction, Gastric acid secretion D00422 Ranitidine 2件: 13, 65
24 KCNQ1 4件: Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D02910 Amiodarone 2件: 28, 127
25 KCNQ1 4件: Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D09569 Ezogabine 2件: 2, 144
26 ATP1A1 9件: Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin 1件: 299
27 ATP1A1 9件: Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin 3件: 8, 46, 210
28 ATP1A2 9件: Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin 1件: 299
29 ATP1A2 9件: Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin 3件: 8, 46, 210
30 ATP1A3 9件: Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin 1件: 299
31 ATP1A3 9件: Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin 3件: 8, 46, 210
32 ATP1A4 9件: Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin 1件: 299
33 ATP1A4 9件: Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin 3件: 8, 46, 210
34 ATP4A 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00355 Lansoprazole 7件: 63, 71, 85, 98, 166, 222, 299
35 ATP4A 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00455 Omeprazole 14件: 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299
36 ATP4A 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D05353 Pantoprazole 2件: 13, 65
37 ATP4A 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D07917 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
38 ATP4A 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08463 Rabeprazole 2件: 2, 51
39 ATP4A 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08903 Dexlansoprazole 1件: 98
40 ATP4A 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D11784 Vonoprazan 2件: 63, 98
41 ATP4B 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00355 Lansoprazole 7件: 63, 71, 85, 98, 166, 222, 299
42 ATP4B 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00455 Omeprazole 14件: 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299
43 ATP4B 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D05353 Pantoprazole 2件: 13, 65
44 ATP4B 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D07917 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
45 ATP4B 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08463 Rabeprazole 2件: 2, 51
46 ATP4B 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08903 Dexlansoprazole 1件: 98
47 ATP4B 3件: Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D11784 Vonoprazan 2件: 63, 98
48 PRKCB 47件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, NF-kappa B signaling pathway, HIF-1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, mTOR signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Neutrophil extracellular trap formation, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Serotonergic synapse, Long-term depression, Inflammatory mediator regulation of TRP channels, Insulin secretion, GnRH signaling pathway, Melanogenesis, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Insulin resistance, Growth hormone synthesis, secretion and action, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Morphine addiction, Leishmaniasis, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Glioma, Non-small cell lung cancer, Hepatocellular carcinoma D11935 Enzastaurin 1件: 168
49 SSTR2 3件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D00442 Octreotide 7件: 67, 75, 84, 85, 89, 193, 227
50 SSTR2 3件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D07431 Somatostatin 2件: 67, 78
51 SSTR2 3件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D10147 Pasireotide 3件: 67, 74, 75
52 CA2 5件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
53 CA2 5件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D00518 Diclofenamide 1件: 114
54 CA2 5件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
55 CA2 5件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D07871 Dorzolamide 1件: 90
56 CCKBR 2件: Neuroactive ligand-receptor interaction, Gastric acid secretion D01818 Proglumide 1件: 298