Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
3 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
4 Alcoholism 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
5 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
6 Aldosterone-regulated sodium reabsorption 💬
 [1] NR3C2 💬 D01115 💬 Eplerenone [4] 75, 113, 210, 215 💬
7 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
8 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
9 Amyotrophic lateral sclerosis 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
10 Apelin signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
11 Calcium signaling pathway 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
12 Calcium signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
13 Calcium signaling pathway 💬
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
14 cAMP signaling pathway 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
15 cAMP signaling pathway 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
16 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D00514 💬 Dexmedetomidine [14]  2 ,  4 ,  6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
17 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
18 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
19 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
20 Circadian entrainment 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
21 Cocaine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
22 Complement and coagulation cascades 💬
 [1] PLG 💬 D01136 💬 Tranexamic acid [7] 46, 70, 215, 227, 274, 288, 299 💬
23 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
24 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
25 Cushing syndrome 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
26 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
27 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
28 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
29 Estrogen signaling pathway 💬
 [1] OPRM1 💬 D00320 💬 Fentanyl [3] 46, 70, 215 💬
30 Gap junction 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
31 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
32 Huntington disease 💬
 [2] GRIN1, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
33 Influenza A 💬
 [1] PLG 💬 D01136 💬 Tranexamic acid [7] 46, 70, 215, 227, 274, 288, 299 💬
34 Long-term potentiation 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
35 Morphine addiction 💬
 [1] OPRM1 💬 D00320 💬 Fentanyl [3] 46, 70, 215 💬
36 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D00514 💬 Dexmedetomidine [14]  2 ,  4 ,  6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
37 Neuroactive ligand-receptor interaction 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
38 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
39 Neuroactive ligand-receptor interaction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
40 Neuroactive ligand-receptor interaction 💬
 [1] OPRM1 💬 D00320 💬 Fentanyl [3] 46, 70, 215 💬
41 Neuroactive ligand-receptor interaction 💬
 [1] PLG 💬 D01136 💬 Tranexamic acid [7] 46, 70, 215, 227, 274, 288, 299 💬
42 Nicotine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
43 Pathways in cancer 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
44 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
45 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
46 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
47 Rap1 signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
48 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
49 Regulation of lipolysis in adipocytes 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
50 Renin secretion 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
51 Renin secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
52 Renin-angiotensin system 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
53 Salivary secretion 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
54 Spinocerebellar ataxia 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
55 Staphylococcus aureus infection 💬
 [1] PLG 💬 D01136 💬 Tranexamic acid [7] 46, 70, 215, 227, 274, 288, 299 💬
56 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
57 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬

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