Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
2 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
3 cAMP signaling pathway 💬
 [1] EDNRA 💬 D01227 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
4 cAMP signaling pathway 💬
 [1] EDNRA 💬 D07538 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
5 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
6 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
7 Complement and coagulation cascades 💬
 [1] SERPINC1 💬 D07510 💬 Heparin [11] 47, 60, 70, 84, 107, 224, 226, 280, 299, 316, 317 💬
8 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
9 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
10 Insulin secretion 💬
 [1] SNAP25 💬 D00783 💬 Botulinum toxin type A [14]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬
11 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
12 Melanogenesis 💬
 [1] EDNRB 💬 D01227 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
13 Melanogenesis 💬
 [1] EDNRB 💬 D07538 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
14 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
15 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
16 Pathways in cancer 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
17 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
18 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
19 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
20 Relaxin signaling pathway 💬
 [1] EDNRB 💬 D01227 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
21 Relaxin signaling pathway 💬
 [1] EDNRB 💬 D07538 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
22 Renin secretion 💬
 [1] EDNRA 💬 D01227 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
23 Renin secretion 💬
 [1] EDNRA 💬 D07538 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
24 Synaptic vesicle cycle 💬
 [1] SNAP25 💬 D00783 💬 Botulinum toxin type A [14]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬
25 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D01227 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
26 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D07538 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

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