Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D07874 💬 Doxazosin [2] 57, 67 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
4 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
5 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
6 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
7 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
8 AMPK signaling pathway 💬
 [1] ADRA1A 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
9 AMPK signaling pathway 💬
 [1] ADRA1A 💬 D07874 💬 Doxazosin [2] 57, 67 💬
10 Apelin signaling pathway 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
11 Caffeine metabolism 💬
 [1] XDH 💬 D00224 💬 Allopurinol [7]  6 , 46, 57, 60, 66, 96, 97 💬
12 Calcium signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D07874 💬 Doxazosin [2] 57, 67 💬
13 Calcium signaling pathway 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
14 Calcium signaling pathway 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
15 Calcium signaling pathway 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
16 Calcium signaling pathway 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
17 cAMP signaling pathway 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
18 cAMP signaling pathway 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
19 cAMP signaling pathway 💬
 [2] ADRB1, ADRB2 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
20 cGMP-PKG signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D07874 💬 Doxazosin [2] 57, 67 💬
21 cGMP-PKG signaling pathway 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
22 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
23 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
24 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
25 Chagas disease 💬
 [1] ACE 💬 D07499 💬 Benazepril [4] 49, 57, 218, 224 💬
26 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
27 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
28 Chemical carcinogenesis - receptor activation 💬
 [2] ADRB1, ADRB2 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
29 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D07499 💬 Benazepril [4] 49, 57, 218, 224 💬
30 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
31 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
32 Cushing syndrome 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
33 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
34 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
35 Diabetic cardiomyopathy 💬
 [1] ACE 💬 D07499 💬 Benazepril [4] 49, 57, 218, 224 💬
36 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
37 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
38 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
39 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
40 Drug metabolism - other enzymes 💬
 [1] XDH 💬 D00224 💬 Allopurinol [7]  6 , 46, 57, 60, 66, 96, 97 💬
41 Gap junction 💬
 [1] ADRB1 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
42 Gap junction 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
43 Gap junction 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
44 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
45 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
46 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D07499 💬 Benazepril [4] 49, 57, 218, 224 💬
47 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
48 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
49 Metabolic pathways 💬
 [1] XDH 💬 D00224 💬 Allopurinol [7]  6 , 46, 57, 60, 66, 96, 97 💬
50 Neuroactive ligand-receptor interaction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D07874 💬 Doxazosin [2] 57, 67 💬
51 Neuroactive ligand-receptor interaction 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
52 Neuroactive ligand-receptor interaction 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
53 Neuroactive ligand-receptor interaction 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
54 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
55 Nucleotide metabolism 💬
 [1] XDH 💬 D00224 💬 Allopurinol [7]  6 , 46, 57, 60, 66, 96, 97 💬
56 Pathways in cancer 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
57 Pathways in cancer 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
58 Pathways in cancer 💬
 [1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
59 Peroxisome 💬
 [1] XDH 💬 D00224 💬 Allopurinol [7]  6 , 46, 57, 60, 66, 96, 97 💬
60 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
61 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
62 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
63 Purine metabolism 💬
 [1] XDH 💬 D00224 💬 Allopurinol [7]  6 , 46, 57, 60, 66, 96, 97 💬
64 Regulation of lipolysis in adipocytes 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
65 Regulation of lipolysis in adipocytes 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
66 Regulation of lipolysis in adipocytes 💬
 [2] ADRB1, ADRB2 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
67 Renin secretion 💬
 [1] ACE 💬 D07499 💬 Benazepril [4] 49, 57, 218, 224 💬
68 Renin secretion 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
69 Renin secretion 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
70 Renin secretion 💬
 [2] ADRB1, ADRB2 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
71 Renin secretion 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
72 Renin-angiotensin system 💬
 [1] ACE 💬 D07499 💬 Benazepril [4] 49, 57, 218, 224 💬
73 Renin-angiotensin system 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
74 Salivary secretion 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D07874 💬 Doxazosin [2] 57, 67 💬
75 Salivary secretion 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
76 Salivary secretion 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
77 Salivary secretion 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
78 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
79 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D07874 💬 Doxazosin [2] 57, 67 💬
80 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬

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