Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 ErbB signaling pathway 💬
[1] ABL1 💬 D08066 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
2 ErbB signaling pathway 💬
[1] ABL1 💬 D08953 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
3 ErbB signaling pathway 💬
[2] ABL1, SRC 💬 D03252 💬 Bosutinib [2]  2 , 67 💬
4 ErbB signaling pathway 💬
[2] ABL1, SRC 💬 D03658 💬 Dasatinib [2] 51, 85 💬
5 ErbB signaling pathway 💬
[2] ABL1, SRC 💬 D06414 💬 Dasatinib [2] 51, 85 💬
6 ErbB signaling pathway 💬
[2] ABL1, SRC 💬 D09664 💬 Saracatinib [3]  6 , 89, 272 💬
7 ErbB signaling pathway 💬
[1] BRAF 💬 D10064 💬 Dabrafenib [1] 34 💬
8 ErbB signaling pathway 💬
[2] BRAF, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
9 ErbB signaling pathway 💬
[1] EGFR 💬 D03455 💬 Cetuximab [2] 51, 86 💬
10 ErbB signaling pathway 💬
[1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
11 ErbB signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
12 ErbB signaling pathway 💬
[1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
13 ErbB signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
14 ErbB signaling pathway 💬
[2] EGFR, ERBB2 💬 D11772 💬 Tesevatinib [1] 67 💬
15 ErbB signaling pathway 💬
[3] EGFR, ERBB2, ERBB4 💬 D08950 💬 Neratinib [1] 34 💬
16 ErbB signaling pathway 💬
[2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
17 ErbB signaling pathway 💬
[2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
18 ErbB signaling pathway 💬
[2] MAP2K1, MAP2K2 💬 D11675 💬 Mirdametinib [1] 34 💬
19 ErbB signaling pathway 💬
[2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
20 ErbB signaling pathway 💬
[2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
21 ErbB signaling pathway 💬
[1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
22 ErbB signaling pathway 💬
[1] MTOR 💬 D00753 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
23 ErbB signaling pathway 💬
[1] MTOR 💬 D06068 💬 Temsirolimus [1] 13 💬
24 ErbB signaling pathway 💬
[1] PIK3CA 💬 D11011 💬 Alpelisib [1] 138 💬
25 ErbB signaling pathway 💬
[3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
26 ErbB signaling pathway 💬
[1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
27 ErbB signaling pathway 💬
[1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬