Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Transcriptional misregulation in cancer 💬
 [1] CD40 💬 D11357 💬 Bleselumab [1] 222 💬
2 Transcriptional misregulation in cancer 💬
 [1] CD40 💬 D11610 💬 Iscalimab [2] 49, 53 💬
3 Transcriptional misregulation in cancer 💬
 [1] CD40 💬 D11597 💬 Ravagalimab [2] 53, 97 💬
4 Transcriptional misregulation in cancer 💬
 [1] CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
5 Transcriptional misregulation in cancer 💬
 [1] CD86 💬 D03222 💬 Belatacept [1] 46 💬
6 Transcriptional misregulation in cancer 💬
 [3] CSF1R, FLT1, FLT3 💬 D08552 💬 Sunitinib [2] 28, 34 💬
7 Transcriptional misregulation in cancer 💬
 [2] CSF1R, FLT3 💬 D11270 💬 Pexidartinib [1] 34 💬
8 Transcriptional misregulation in cancer 💬
 [1] CSF2 💬 D11343 💬 Otilimab [1] 46 💬
9 Transcriptional misregulation in cancer 💬
 [1] ELANE 💬 D03788 💬 Sivelestat [3] 13, 85, 96 💬
10 Transcriptional misregulation in cancer 💬
 [1] FLT1 💬 D03218 💬 Axitinib [1] 34 💬
11 Transcriptional misregulation in cancer 💬
 [1] FLT1 💬 D08881 💬 Cediranib [1] 34 💬
12 Transcriptional misregulation in cancer 💬
 [1] FLT1 💬 D10481 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
13 Transcriptional misregulation in cancer 💬
 [1] FLT3 💬 D08524 💬 Sorafenib [2] 34, 86 💬
14 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
15 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 D00775 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
16 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 D02696 💬 Talampanel [2]  2 ,  6  💬
17 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
18 Transcriptional misregulation in cancer 💬
 [2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
19 Transcriptional misregulation in cancer 💬
 [1] IGF1R 💬 D09925 💬 Linsitinib [1] 232 💬
20 Transcriptional misregulation in cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
21 Transcriptional misregulation in cancer 💬
 [1] IGF1R 💬 D09680 💬 Teprotumumab [1] 51 💬
22 Transcriptional misregulation in cancer 💬
 [1] IL1R2 💬 D02934 💬 Anakinra [18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
23 Transcriptional misregulation in cancer 💬
 [1] IL2RB 💬 D00748 💬 Aldesleukin [6]  2 , 35, 49, 65, 96, 97 💬
24 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 D12487 💬 Olokizumab [2] 46, 96 💬
25 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
26 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
27 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
28 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
29 Transcriptional misregulation in cancer 💬
 [1] ITGB7 💬 D10540 💬 Abrilumab [2] 96, 97 💬
30 Transcriptional misregulation in cancer 💬
 [1] ITGB7 💬 D09901 💬 Etrolizumab [2] 96, 97 💬
31 Transcriptional misregulation in cancer 💬
 [1] ITGB7 💬 D08083 💬 Vedolizumab [3] 94, 96, 97 💬
32 Transcriptional misregulation in cancer 💬
 [1] MET 💬 D10062 💬 Cabozantinib [1] 34 💬
33 Transcriptional misregulation in cancer 💬
 [1] MPO 💬 D11684 💬 Verdiperstat [3]  2 , 17, 127 💬
34 Transcriptional misregulation in cancer 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
35 Transcriptional misregulation in cancer 💬
 [1] NGFR 💬 D11028 💬 Cenegermin [2] 53, 90 💬
36 Transcriptional misregulation in cancer 💬
 [2] PML, RARA 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
37 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 D12242 💬 Bocidelpar [1] 113 💬
38 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 D11603 💬 Leriglitazone [1] 20 💬
39 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 D08378 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
40 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
41 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 D11256 💬 Seladelpar [2] 93, 94 💬
42 Transcriptional misregulation in cancer 💬
 [1] RARA 💬 D04162 💬 Fenretinide [1] 299 💬
43 Transcriptional misregulation in cancer 💬
 [1] RARA 💬 D00348 💬 Isotretinoin [4] 36, 39, 159, 160 💬
44 Transcriptional misregulation in cancer 💬
 [1] RARA 💬 D01418 💬 Tamibarotene [2] 26, 96 💬
45 Transcriptional misregulation in cancer 💬
 [1] RARA 💬 D06543 💬 Vitamin A [3] 13, 53, 90 💬
46 Transcriptional misregulation in cancer 💬
 [4] RARA, RXRA, RXRB, RXRG 💬 D02754 💬 Acitretin [1] 37 💬
47 Transcriptional misregulation in cancer 💬
 [4] RARA, RXRA, RXRB, RXRG 💬 D02815 💬 Alitretinoin [1] 49 💬
48 Transcriptional misregulation in cancer 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
49 Transcriptional misregulation in cancer 💬
 [3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬