Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Spinocerebellar ataxia 💬
[3] GRIA1, GRIA2, GRIA3 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
2 Spinocerebellar ataxia 💬
[3] GRIA1, GRIA2, GRIA3 💬 D02696 💬 Talampanel [2]  2 ,  6  💬
3 Spinocerebellar ataxia 💬
[3] GRIA1, GRIA2, GRIA3 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
4 Spinocerebellar ataxia 💬
[8] GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
5 Spinocerebellar ataxia 💬
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07058 💬 Acamprosate [2]  6 , 206 💬
6 Spinocerebellar ataxia 💬
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07441 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
7 Spinocerebellar ataxia 💬
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D03742 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
8 Spinocerebellar ataxia 💬
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
9 Spinocerebellar ataxia 💬
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
10 Spinocerebellar ataxia 💬
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D09917 💬 Latrepirdine [1]  8  💬
11 Spinocerebellar ataxia 💬
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
12 Spinocerebellar ataxia 💬
[2] KCNC3, KCND3 💬 D10228 💬 Amifampridine [3]  3 , 11, 12 💬
13 Spinocerebellar ataxia 💬
[2] KCNC3, KCND3 💬 D04127 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
14 Spinocerebellar ataxia 💬
[1] KCND3 💬 D02910 💬 Amiodarone [2] 28, 127 💬
15 Spinocerebellar ataxia 💬
[1] MAP3K5 💬 D10988 💬 Selonsertib [1] 86 💬
16 Spinocerebellar ataxia 💬
[1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
17 Spinocerebellar ataxia 💬
[1] MTOR 💬 D00753 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
18 Spinocerebellar ataxia 💬
[1] MTOR 💬 D06068 💬 Temsirolimus [1] 13 💬
19 Spinocerebellar ataxia 💬
[1] PIK3CA 💬 D11011 💬 Alpelisib [1] 138 💬
20 Spinocerebellar ataxia 💬
[3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
21 Spinocerebellar ataxia 💬
[1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
22 Spinocerebellar ataxia 💬
[1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
23 Spinocerebellar ataxia 💬
[1] PSMB5 💬 D03150 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬
24 Spinocerebellar ataxia 💬
[1] PSMB5 💬 D08880 💬 Carfilzomib [1] 28 💬
25 Spinocerebellar ataxia 💬
[1] PSMB5 💬 D10130 💬 Ixazomib [5] 13, 16, 28, 51, 61 💬