Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Hepatocellular carcinoma 💬
[1] BRAF 💬 D10064 💬 Dabrafenib [1] 34 💬
2 Hepatocellular carcinoma 💬
[2] BRAF, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
3 Hepatocellular carcinoma 💬
[2] CDK4, CDK6 💬 D10688 💬 Abemaciclib [1] 34 💬
4 Hepatocellular carcinoma 💬
[1] EGFR 💬 D03455 💬 Cetuximab [2] 51, 86 💬
5 Hepatocellular carcinoma 💬
[1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
6 Hepatocellular carcinoma 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
7 Hepatocellular carcinoma 💬
[1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
8 Hepatocellular carcinoma 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
9 Hepatocellular carcinoma 💬
[1] EGFR 💬 D08950 💬 Neratinib [1] 34 💬
10 Hepatocellular carcinoma 💬
[1] EGFR 💬 D11772 💬 Tesevatinib [1] 67 💬
11 Hepatocellular carcinoma 💬
[1] HMOX1 💬 D05922 💬 Stannsoporfin [1] 254 💬
12 Hepatocellular carcinoma 💬
[1] IGF1R 💬 D09925 💬 Linsitinib [1] 232 💬
13 Hepatocellular carcinoma 💬
[1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
14 Hepatocellular carcinoma 💬
[1] IGF1R 💬 D09680 💬 Teprotumumab [1] 51 💬
15 Hepatocellular carcinoma 💬
[1] KEAP1 💬 D03846 💬 Dimethyl fumarate [5] 13, 49, 51, 86, 296 💬
16 Hepatocellular carcinoma 💬
[2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
17 Hepatocellular carcinoma 💬
[2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
18 Hepatocellular carcinoma 💬
[2] MAP2K1, MAP2K2 💬 D11675 💬 Mirdametinib [1] 34 💬
19 Hepatocellular carcinoma 💬
[2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
20 Hepatocellular carcinoma 💬
[2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
21 Hepatocellular carcinoma 💬
[1] MET 💬 D10062 💬 Cabozantinib [1] 34 💬
22 Hepatocellular carcinoma 💬
[1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
23 Hepatocellular carcinoma 💬
[1] MTOR 💬 D00753 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
24 Hepatocellular carcinoma 💬
[1] MTOR 💬 D06068 💬 Temsirolimus [1] 13 💬
25 Hepatocellular carcinoma 💬
[1] NFE2L2 💬 D10964 💬 Omaveloxolone [1] 18 💬
26 Hepatocellular carcinoma 💬
[1] NQO1 💬 D08682 💬 Warfarin [11]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
27 Hepatocellular carcinoma 💬
[1] PIK3CA 💬 D11011 💬 Alpelisib [1] 138 💬
28 Hepatocellular carcinoma 💬
[3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
29 Hepatocellular carcinoma 💬
[1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
30 Hepatocellular carcinoma 💬
[1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
31 Hepatocellular carcinoma 💬
[3] TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab [3] 51, 85, 222 💬