DDrare: Database of Drug Development for Rare Diseases

Magnesium sulfate (DrugBank: Magnesium sulfate, Magnesium, Sulfate)

17 diseases

ID	Disease name (Link within this page)	Number of trials
6	Parkinson disease	0
11	Myasthenia	1
13	Multiple sclerosis/Neuromyelitis optica	0
46	Malignant rheumatoid arthritis	0
51	Scleroderma	0
64	Thrombotic thrombocytopenic purpura	1
70	Spinal stenosis	1
93	Primary biliary cholangitis [Primary biliary cirrhosis (~Mar 2017)]	0
97	Ulcerative colitis	0
166	Pseudoxanthoma elasticum	0
225	Congenital nephrogenic diabetes insipidus	0
235	Hypoparathyroidism	0
284	Diamond-Blackfan anemia	0
291	Hirschsprung disease, entire colon type	0
296	Biliary atresia	1
297	Alagille syndrome	1
298	Hereditary pancreatitis	0

6. Parkinson disease [ 2,123 clinical trials, 2,046 drugs, (DrugBank: 324 drugs), 183 drug target genes, 198 drug target pathways]

Searched query = "Parkinson disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 2,123 trial found

11. Myasthenia [ 226 clinical trials, 172 drugs, (DrugBank: 45 drugs), 43 drug target genes, 118 drug target pathways]

Searched query = "Myasthenia", "MG"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 226 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR1800017696	2016-07-01	2018-08-10	Effect of Magnesium Sulfate on Muscle Strength in Patients with Myasthenia Gravis	Effect of Magnesium Sulfate on Muscle Strength in Patients with Myasthenia Gravis	Myasthenia Gravis	Group A:Magnesium Sulfate;Group B:Normal saline;	The University of Hong Kong-Shenzhen Hospital	NULL	Recruiting	18	60	Both	Group A:30;Group B:30;		China

13. Multiple sclerosis/Neuromyelitis optica [ 3,050 clinical trials, 2,147 drugs, (DrugBank: 348 drugs), 244 drug target genes, 228 drug target pathways]

Searched query = "Multiple sclerosis/Neuromyelitis optica", "Multiple sclerosis", "Neuromyelitis optica", "MS", "NMOSD", "Devic disease", "Balo concentric sclerosis", "Baló concentric sclerosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 3,050 trial found

46. Malignant rheumatoid arthritis [ 4,183 clinical trials, 2,538 drugs, (DrugBank: 401 drugs), 183 drug target genes, 219 drug target pathways]

Searched query = "Malignant rheumatoid arthritis", "Rheumatoid arthritis", "Rheumatoid arthritis with vasculitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 4,183 trial found

51. Scleroderma [ 466 clinical trials, 536 drugs, (DrugBank: 142 drugs), 110 drug target genes, 210 drug target pathways]

Searched query = "Scleroderma", "Systemic sclerosis", "SSc", "dcSSc", "lcSSc"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 466 trial found

64. Thrombotic thrombocytopenic purpura [ 74 clinical trials, 76 drugs, (DrugBank: 19 drugs), 15 drug target genes, 57 drug target pathways]

Searched query = "Thrombotic thrombocytopenic purpura", "TTP", "Upshaw-Schulman syndrome", "USS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 74 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03237819 (ClinicalTrials.gov)	December 2017	13/6/2017	Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care	Interest of Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care: Multicentric Randomized Controlled Trial	Thrombotic Thrombocytopenic Purpura	Drug: Sulfate, Magnesium;Drug: Placebo - Concentrate	Assistance Publique - Hôpitaux de Paris	NULL	Not yet recruiting	18 Years	N/A	All	74	Phase 3	France

70. Spinal stenosis [ 91 clinical trials, 195 drugs, (DrugBank: 54 drugs), 60 drug target genes, 85 drug target pathways]

Searched query = "Spinal stenosis", "Extensive spinal canal stenosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 91 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04391855 (ClinicalTrials.gov)	May 10, 2020	13/5/2020	Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine Surgery	Effect of Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Sulfate as Adjuncts to the Local Anesthetic on Pain Relief After Spine Surgery	Analgesia;Pain, Postoperative;Spinal Stenosis;Spinal Disease	Drug: Tramadol with ropivacaine;Drug: Dexmedetomidine with ropivacaine;Drug: Magnesium with ropivacaine;Drug: Ropivacaine plus normal saline	Aristotle University Of Thessaloniki	NULL	Recruiting	18 Years	80 Years	All	78	Phase 4	Greece

93. Primary biliary cholangitis [Primary biliary cirrhosis (~Mar 2017)] [ 230 clinical trials, 215 drugs, (DrugBank: 51 drugs), 34 drug target genes, 107 drug target pathways]

Searched query = "Primary biliary cholangitis", "Primary biliary cirrhosis", "PBC"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 230 trial found

97. Ulcerative colitis [ 2,269 clinical trials, 1,331 drugs, (DrugBank: 241 drugs), 114 drug target genes, 181 drug target pathways]

Searched query = "Ulcerative colitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 2,269 trial found

166. Pseudoxanthoma elasticum [ 11 clinical trials, 23 drugs, (DrugBank: 6 drugs), 5 drug target genes, 26 drug target pathways]

Searched query = "Pseudoxanthoma elasticum", "PXE"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 11 trial found

225. Congenital nephrogenic diabetes insipidus [ 12 clinical trials, 45 drugs, (DrugBank: 17 drugs), 30 drug target genes, 63 drug target pathways]

Searched query = "Congenital nephrogenic diabetes insipidus", "Hereditary nephrogenic diabetes insipidus", "Nephrogenic diabetes insipidus"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 12 trial found

235. Hypoparathyroidism [ 67 clinical trials, 112 drugs, (DrugBank: 24 drugs), 4 drug target genes, 5 drug target pathways]

Searched query = "Hypoparathyroidism", "Accessory thyroid hypergasia disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 67 trial found

284. Diamond-Blackfan anemia [ 37 clinical trials, 110 drugs, (DrugBank: 34 drugs), 22 drug target genes, 121 drug target pathways]

Searched query = "Diamond-Blackfan anemia"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 37 trial found

291. Hirschsprung disease, entire colon type [ 13 clinical trials, 32 drugs, (DrugBank: 15 drugs), 0 drug target gene, 0 drug target pathway]

Searched query = "Hirschsprung disease, entire colon type", "Hirschsprung disease, small intestine type", "Hirschsprung disease", "Hirschprung disease", "Hirschsprung disease associated entercolitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 13 trial found

296. Biliary atresia [ 53 clinical trials, 56 drugs, (DrugBank: 31 drugs), 43 drug target genes, 50 drug target pathways]

Searched query = "Biliary atresia"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 53 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00007033 (ClinicalTrials.gov)	October 2000	6/12/2000	Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease		Alagille Syndrome;Cholestasis;Biliary Atresia	Drug: magnesium gluconate;Drug: magnesium sulfate	National Center for Research Resources (NCRR)	Children's Hospital Medical Center, Cincinnati	Completed	3 Years	18 Years	Both	25	N/A	United States

297. Alagille syndrome [ 26 clinical trials, 16 drugs, (DrugBank: 8 drugs), 2 drug target genes, 2 drug target pathways]

Searched query = "Alagille syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 26 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00007033 (ClinicalTrials.gov)	October 2000	6/12/2000	Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease		Alagille Syndrome;Cholestasis;Biliary Atresia	Drug: magnesium gluconate;Drug: magnesium sulfate	National Center for Research Resources (NCRR)	Children's Hospital Medical Center, Cincinnati	Completed	3 Years	18 Years	Both	25	N/A	United States

298. Hereditary pancreatitis [ 93 clinical trials, 168 drugs, (DrugBank: 51 drugs), 48 drug target genes, 134 drug target pathways]

Searched query = "Hereditary pancreatitis", "Chronic pancreatitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 93 trial found