Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 CETP [1] Cholesterol metabolism D08855 Anacetrapib [1] 79
2 PCSK9 [1] Cholesterol metabolism D10335 Alirocumab [1] 79
3 PCSK9 [1] Cholesterol metabolism D10557 Evolocumab [2] 79, 222
4 PCSK9 [1] Cholesterol metabolism D11931 Inclisiran [1] 79
5 ANGPTL3 [1] Cholesterol metabolism D11753 Evinacumab [1] 79
6 NR3C1 [1] Neuroactive ligand-receptor interaction D00473 Prednisone [24] 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
7 NPC1L1 [1] Fat digestion and absorption D01966 Ezetimibe [3] 79, 93, 260
8 HMGCR [4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D00359 Lovastatin [11] 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
9 HMGCR [4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D00434 Simvastatin [21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
10 HMGCR [4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D00887 Atorvastatin [18] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
11 HMGCR [4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D00892 Fluvastatin [3] 79, 218, 222
12 HMGCR [4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D00893 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333
13 HMGCR [4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D01915 Rosuvastatin [11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
14 HMGCR [4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D07474 Atorvastatin [18] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
15 HMGCR [4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D07983 Fluvastatin [3] 79, 218, 222
16 HMGCR [4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D08410 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333
17 HMGCR [4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D08492 Rosuvastatin [11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
18 MTTP [1] Fat digestion and absorption D09637 Lomitapide [1] 79
19 SERPINC1 [1] Complement and coagulation cascades D07510 Heparin [9] 79, 84, 107, 224, 226, 280, 299, 316, 317
20 PPARA [10] PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hepatitis C, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy D00565 Fenofibrate [5] 8, 79, 93, 94, 265