Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Non-alcoholic fatty liver disease 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
2 Non-alcoholic fatty liver disease 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
3 Non-alcoholic fatty liver disease 💬
 [4] IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
4 Non-alcoholic fatty liver disease 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
5 Non-alcoholic fatty liver disease 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
6 Non-alcoholic fatty liver disease 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
7 Non-alcoholic fatty liver disease 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
8 Non-alcoholic fatty liver disease 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
9 Non-alcoholic fatty liver disease 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
10 Non-alcoholic fatty liver disease 💬
 [1] IL6R 💬 D11079 💬 Satralizumab [2] 11, 13 💬
11 Non-alcoholic fatty liver disease 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [21]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
12 Non-alcoholic fatty liver disease 💬
 [1] INSR 💬 D04539 💬 Insulin detemir [1] 299 💬
13 Non-alcoholic fatty liver disease 💬
 [1] INSR 💬 D03250 💬 Insulin glargine [1] 299 💬
14 Non-alcoholic fatty liver disease 💬
 [1] INSR 💬 D00085 💬 Insulin human [2] 96, 156 💬
15 Non-alcoholic fatty liver disease 💬
 [1] INSR 💬 D03230 💬 Insulin human [2] 96, 156 💬
16 Non-alcoholic fatty liver disease 💬
 [1] LEPR 💬 D05014 💬 Metreleptin [1] 265 💬
17 Non-alcoholic fatty liver disease 💬
 [1] MAP3K5 💬 D10988 💬 Selonsertib [1] 86 💬
18 Non-alcoholic fatty liver disease 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
19 Non-alcoholic fatty liver disease 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
20 Non-alcoholic fatty liver disease 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
21 Non-alcoholic fatty liver disease 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
22 Non-alcoholic fatty liver disease 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
23 Non-alcoholic fatty liver disease 💬
 [1] PPARA 💬 D01366 💬 Bezafibrate [7] 20, 93, 94, 160, 296, 316, 324 💬
24 Non-alcoholic fatty liver disease 💬
 [1] PPARA 💬 D11208 💬 Elafibranor [1] 93 💬
25 Non-alcoholic fatty liver disease 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [5]  8 , 79, 93, 94, 265 💬
26 Non-alcoholic fatty liver disease 💬
 [1] PPARA 💬 D10711 💬 Pemafibrate [1] 93 💬
27 Non-alcoholic fatty liver disease 💬
 [1] PPARG 💬 D11603 💬 Leriglitazone [1] 20 💬
28 Non-alcoholic fatty liver disease 💬
 [1] PPARG 💬 D00945 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
29 Non-alcoholic fatty liver disease 💬
 [1] PPARG 💬 D08378 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
30 Non-alcoholic fatty liver disease 💬
 [1] PPARG 💬 D00596 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
31 Non-alcoholic fatty liver disease 💬
 [1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
32 Non-alcoholic fatty liver disease 💬
 [1] PPARG 💬 D11256 💬 Seladelpar [2] 93, 94 💬
33 Non-alcoholic fatty liver disease 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [24]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
34 Non-alcoholic fatty liver disease 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [24]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
35 Non-alcoholic fatty liver disease 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
36 Non-alcoholic fatty liver disease 💬
 [1] RXRA 💬 D02754 💬 Acitretin [1] 37 💬
37 Non-alcoholic fatty liver disease 💬
 [1] RXRA 💬 D02815 💬 Alitretinoin [1] 49 💬
38 Non-alcoholic fatty liver disease 💬
 [1] RXRA 💬 D03106 💬 Bexarotene [2] 13, 75 💬
39 Non-alcoholic fatty liver disease 💬
 [1] TGFB1 💬 D09620 💬 Fresolimumab [4] 51, 85, 222, 274 💬
40 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
41 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
42 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
43 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
44 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
45 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
46 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
47 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
48 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬