Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Insulin resistance 💬
 [2] CPT1A, CPT1B 💬 D05442 💬 Perhexiline [2] 58, 272 💬
2 Insulin resistance 💬
 [2] CPT1A, CPT1B 💬 D08340 💬 Perhexiline [2] 58, 272 💬
3 Insulin resistance 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
4 Insulin resistance 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
5 Insulin resistance 💬
 [2] IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
6 Insulin resistance 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
7 Insulin resistance 💬
 [1] INSR 💬 D04539 💬 Insulin detemir [1] 299 💬
8 Insulin resistance 💬
 [1] INSR 💬 D03250 💬 Insulin glargine [1] 299 💬
9 Insulin resistance 💬
 [1] INSR 💬 D00085 💬 Insulin human [2] 96, 156 💬
10 Insulin resistance 💬
 [1] INSR 💬 D03230 💬 Insulin human [2] 96, 156 💬
11 Insulin resistance 💬
 [1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
12 Insulin resistance 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [41]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
13 Insulin resistance 💬
 [1] MTOR 💬 D06068 💬 Temsirolimus [4] 13, 34, 89, 331 💬
14 Insulin resistance 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
15 Insulin resistance 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
16 Insulin resistance 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
17 Insulin resistance 💬
 [1] PPARA 💬 D01366 💬 Bezafibrate [7] 20, 93, 94, 160, 296, 316, 324 💬
18 Insulin resistance 💬
 [1] PPARA 💬 D11208 💬 Elafibranor [1] 93 💬
19 Insulin resistance 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [5]  8 , 79, 93, 94, 265 💬
20 Insulin resistance 💬
 [1] PPARA 💬 D10711 💬 Pemafibrate [1] 93 💬
21 Insulin resistance 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [24]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
22 Insulin resistance 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [24]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
23 Insulin resistance 💬
 [3] PRKCD, PRKCE, PRKCQ 💬 D09671 💬 Sotrastaurin [1] 97 💬
24 Insulin resistance 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
25 Insulin resistance 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
26 Insulin resistance 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
27 Insulin resistance 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
28 Insulin resistance 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
29 Insulin resistance 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
30 Insulin resistance 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
31 Insulin resistance 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
32 Insulin resistance 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
33 Insulin resistance 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬