Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 JAK-STAT signaling pathway 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
2 JAK-STAT signaling pathway 💬
 [1] CSF2 💬 D11343 💬 Otilimab [2] 46, 256 💬
3 JAK-STAT signaling pathway 💬
 [1] CSF2RA 💬 D09930 💬 Mavrilimumab [2] 41, 46 💬
4 JAK-STAT signaling pathway 💬
 [1] CSF2RA 💬 D05066 💬 Molgramostim [3] 97, 229, 299 💬
5 JAK-STAT signaling pathway 💬
 [1] CSF2RA 💬 D05712 💬 Regramostim [1] 229 💬
6 JAK-STAT signaling pathway 💬
 [1] CSF2RA 💬 D05803 💬 Sargramostim [7]  6 , 28, 60, 62, 96, 229, 285 💬
7 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [34]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
8 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
9 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 D06889 💬 Pegfilgrastim [1] 60 💬
10 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 D03455 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
11 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 D04023 💬 Erlotinib [1] 94 💬
12 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
13 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
14 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
15 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 D04024 💬 Lapatinib [3] 34, 74, 75 💬
16 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
17 JAK-STAT signaling pathway 💬
 [1] EGFR 💬 D11772 💬 Tesevatinib [1] 67 💬
18 JAK-STAT signaling pathway 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
19 JAK-STAT signaling pathway 💬
 [1] EPOR 💬 D09946 💬 Peginesatide [1] 283 💬
20 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D11486 💬 Lonapegsomatropin [1] 78 💬
21 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
22 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
23 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D05394 💬 Pegvisomant [1] 78 💬
24 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D11194 💬 Somapacitan [1] 78 💬
25 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D02691 💬 Somatotropin [23]  2 ,  3 , 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299 💬
26 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D11193 💬 Somavaratan [1] 78 💬
27 JAK-STAT signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab [1] 49 💬
28 JAK-STAT signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab [1] 49 💬
29 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab [2] 46, 49 💬
30 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬
31 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a [1] 56 💬
32 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b [2] 25, 34 💬
33 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬
34 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b [1] 13 💬
35 JAK-STAT signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a [1] 13 💬
36 JAK-STAT signaling pathway 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [2] 49, 107 💬
37 JAK-STAT signaling pathway 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
38 JAK-STAT signaling pathway 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
39 JAK-STAT signaling pathway 💬
 [2] IL10, IL6 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
40 JAK-STAT signaling pathway 💬
 [1] IL11RA 💬 D05266 💬 Oprelvekin [2] 96, 288 💬
41 JAK-STAT signaling pathway 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
42 JAK-STAT signaling pathway 💬
 [1] IL13 💬 D08857 💬 Anrukinzumab [1] 97 💬
43 JAK-STAT signaling pathway 💬
 [1] IL13 💬 D09633 💬 Lebrikizumab [1] 85 💬
44 JAK-STAT signaling pathway 💬
 [1] IL13 💬 D09979 💬 Tralokinumab [2] 85, 97 💬
45 JAK-STAT signaling pathway 💬
 [1] IL20 💬 D11756 💬 Fletikumab [1] 46 💬
46 JAK-STAT signaling pathway 💬
 [1] IL22 💬 D11953 💬 Efmarodocokin alfa [2] 96, 97 💬
47 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 D10912 💬 Brazikumab [2] 96, 97 💬
48 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [5] 37, 41, 51, 96, 97 💬
49 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 D11123 💬 Mirikizumab [3] 37, 96, 97 💬
50 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 D11052 💬 Risankizumab [4] 37, 96, 97, 271 💬
51 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 D10400 💬 Tildrakizumab [2] 162, 271 💬
52 JAK-STAT signaling pathway 💬
 [1] IL2RA 💬 D03058 💬 Basiliximab [6]  2 , 50, 66, 97, 222, 228 💬
53 JAK-STAT signaling pathway 💬
 [1] IL2RA 💬 D03639 💬 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284 💬
54 JAK-STAT signaling pathway 💬
 [3] IL2RA, IL2RB, IL2RG 💬 D00748 💬 Aldesleukin [6]  2 , 35, 49, 65, 96, 97 💬
55 JAK-STAT signaling pathway 💬
 [1] IL4 💬 D03117 💬 Binetrakin [1] 46 💬
56 JAK-STAT signaling pathway 💬
 [1] IL4R 💬 D10354 💬 Dupilumab [4] 51, 98, 160, 162 💬
57 JAK-STAT signaling pathway 💬
 [1] IL5 💬 D04923 💬 Mepolizumab [4] 44, 45, 98, 162 💬
58 JAK-STAT signaling pathway 💬
 [1] IL5 💬 D08985 💬 Reslizumab [2] 44, 98 💬
59 JAK-STAT signaling pathway 💬
 [1] IL5RA 💬 D09874 💬 Benralizumab [5] 44, 45, 98, 162, 299 💬
60 JAK-STAT signaling pathway 💬
 [1] IL6 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
61 JAK-STAT signaling pathway 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
62 JAK-STAT signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
63 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
64 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 D11079 💬 Satralizumab [2] 11, 13 💬
65 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [21]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
66 JAK-STAT signaling pathway 💬
 [1] JAK1 💬 D10871 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
67 JAK-STAT signaling pathway 💬
 [1] JAK1 💬 D10944 💬 Itacitinib [5] 46, 51, 60, 97, 228 💬
68 JAK-STAT signaling pathway 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
69 JAK-STAT signaling pathway 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
70 JAK-STAT signaling pathway 💬
 [2] JAK1, JAK2 💬 D09959 💬 Ruxolitinib [1] 228 💬
71 JAK-STAT signaling pathway 💬
 [3] JAK1, JAK2, JAK3 💬 D10653 💬 Peficitinib [1] 46 💬
72 JAK-STAT signaling pathway 💬
 [4] JAK1, JAK2, JAK3, TYK2 💬 D09970 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
73 JAK-STAT signaling pathway 💬
 [1] LEPR 💬 D05014 💬 Metreleptin [1] 265 💬
74 JAK-STAT signaling pathway 💬
 [1] MPL 💬 D10306 💬 Avatrombopag [2] 60, 63 💬
75 JAK-STAT signaling pathway 💬
 [1] MPL 💬 D08990 💬 Romiplostim [4] 60, 63, 64, 65 💬
76 JAK-STAT signaling pathway 💬
 [1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
77 JAK-STAT signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [41]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
78 JAK-STAT signaling pathway 💬
 [1] MTOR 💬 D06068 💬 Temsirolimus [4] 13, 34, 89, 331 💬
79 JAK-STAT signaling pathway 💬
 [1] PDGFRA 💬 D01441 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
80 JAK-STAT signaling pathway 💬
 [1] PDGFRA 💬 D08066 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
81 JAK-STAT signaling pathway 💬
 [2] PDGFRA, PDGFRB 💬 D08953 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
82 JAK-STAT signaling pathway 💬
 [2] PDGFRA, PDGFRB 💬 D10481 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
83 JAK-STAT signaling pathway 💬
 [2] PDGFRA, PDGFRB 💬 D06402 💬 Sunitinib [2] 28, 34 💬
84 JAK-STAT signaling pathway 💬
 [2] PDGFRA, PDGFRB 💬 D08552 💬 Sunitinib [2] 28, 34 💬
85 JAK-STAT signaling pathway 💬
 [1] PDGFRB 💬 D03658 💬 Dasatinib [2] 51, 85 💬
86 JAK-STAT signaling pathway 💬
 [1] PDGFRB 💬 D06414 💬 Dasatinib [2] 51, 85 💬
87 JAK-STAT signaling pathway 💬
 [2] PDGFRB, RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
88 JAK-STAT signaling pathway 💬
 [2] PDGFRB, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
89 JAK-STAT signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
90 JAK-STAT signaling pathway 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
91 JAK-STAT signaling pathway 💬
 [1] PRL 💬 D00780 💬 Bromocriptine [2]  6 , 74 💬
92 JAK-STAT signaling pathway 💬
 [1] PRL 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
93 JAK-STAT signaling pathway 💬
 [1] PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
94 JAK-STAT signaling pathway 💬
 [1] PRL 💬 D01348 💬 Terguride [2] 51, 86 💬
95 JAK-STAT signaling pathway 💬
 [1] TYK2 💬 D11817 💬 Deucravacitinib [2] 96, 97 💬