Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Fat digestion and absorption 💬
 [1] MTTP 💬 D09637 💬 Lomitapide [1] 79 💬
2 Fat digestion and absorption 💬
 [1] NPC1L1 💬 D01966 💬 Ezetimibe [4] 49, 79, 93, 260 💬
3 Fatty acid degradation 💬
 [3] ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole [1] 301 💬
4 Fatty acid degradation 💬
 [4] CPT1A, CPT1B, CPT1C, CPT2 💬 D05442 💬 Perhexiline [2] 58, 272 💬
5 Fatty acid degradation 💬
 [4] CPT1A, CPT1B, CPT1C, CPT2 💬 D08340 💬 Perhexiline [2] 58, 272 💬
6 Fatty acid metabolism 💬
 [4] CPT1A, CPT1B, CPT1C, CPT2 💬 D05442 💬 Perhexiline [2] 58, 272 💬
7 Fatty acid metabolism 💬
 [4] CPT1A, CPT1B, CPT1C, CPT2 💬 D08340 💬 Perhexiline [2] 58, 272 💬
8 Fc epsilon RI signaling pathway 💬
 [1] ALOX5 💬 D01773 💬 Oxatomide [1] 113 💬
9 Fc epsilon RI signaling pathway 💬
 [1] ALOX5 💬 D00414 💬 Zileuton [3] 85, 160, 164 💬
10 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 D10893 💬 Acalabrutinib [2] 46, 61 💬
11 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 D11478 💬 Branebrutinib [3] 46, 49, 53 💬
12 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 D11457 💬 Fenebrutinib [1] 13 💬
13 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 D10223 💬 Ibrutinib [3] 28, 60, 61 💬
14 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 D12160 💬 Orelabrutinib [3] 13, 61, 63 💬
15 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 D11422 💬 Zanubrutinib [2] 300, 331 💬
16 Fc epsilon RI signaling pathway 💬
 [1] CSF2 💬 D11343 💬 Otilimab [2] 46, 256 💬
17 Fc epsilon RI signaling pathway 💬
 [1] FCER1A 💬 D05251 💬 Omalizumab [7] 46, 53, 65, 98, 162, 226, 299 💬
18 Fc epsilon RI signaling pathway 💬
 [1] FYN 💬 D03658 💬 Dasatinib [2] 51, 85 💬
19 Fc epsilon RI signaling pathway 💬
 [1] FYN 💬 D06414 💬 Dasatinib [2] 51, 85 💬
20 Fc epsilon RI signaling pathway 💬
 [1] IL13 💬 D08857 💬 Anrukinzumab [1] 97 💬
21 Fc epsilon RI signaling pathway 💬
 [1] IL13 💬 D09633 💬 Lebrikizumab [1] 85 💬
22 Fc epsilon RI signaling pathway 💬
 [1] IL13 💬 D09979 💬 Tralokinumab [2] 85, 97 💬
23 Fc epsilon RI signaling pathway 💬
 [1] IL4 💬 D03117 💬 Binetrakin [1] 46 💬
24 Fc epsilon RI signaling pathway 💬
 [1] IL5 💬 D04923 💬 Mepolizumab [4] 44, 45, 98, 162 💬
25 Fc epsilon RI signaling pathway 💬
 [1] IL5 💬 D08985 💬 Reslizumab [2] 44, 98 💬
26 Fc epsilon RI signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
27 Fc epsilon RI signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
28 Fc epsilon RI signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
29 Fc epsilon RI signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
30 Fc epsilon RI signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
31 Fc epsilon RI signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
32 Fc epsilon RI signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
33 Fc epsilon RI signaling pathway 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
34 Fc epsilon RI signaling pathway 💬
 [1] RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
35 Fc epsilon RI signaling pathway 💬
 [1] RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
36 Fc epsilon RI signaling pathway 💬
 [1] SYK 💬 D09347 💬 Fostamatinib [4] 46, 49, 61, 66 💬
37 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
38 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
39 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
40 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
41 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
42 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
43 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
44 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
45 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
46 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
47 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
48 Fc gamma R-mediated phagocytosis 💬
 [1] MAP2K1 💬 D10604 💬 Binimetinib [1] 34 💬
49 Fc gamma R-mediated phagocytosis 💬
 [1] MAP2K1 💬 D10405 💬 Cobimetinib [1] 280 💬
50 Fc gamma R-mediated phagocytosis 💬
 [1] MAP2K1 💬 D09666 💬 Selumetinib [1] 34 💬
51 Fc gamma R-mediated phagocytosis 💬
 [1] MAP2K1 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
52 Fc gamma R-mediated phagocytosis 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
53 Fc gamma R-mediated phagocytosis 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
54 Fc gamma R-mediated phagocytosis 💬
 [2] PRKCD, PRKCE 💬 D09671 💬 Sotrastaurin [1] 97 💬
55 Fc gamma R-mediated phagocytosis 💬
 [1] RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
56 Fc gamma R-mediated phagocytosis 💬
 [1] RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
57 Fc gamma R-mediated phagocytosis 💬
 [1] SYK 💬 D09347 💬 Fostamatinib [4] 46, 49, 61, 66 💬
58 Ferroptosis 💬
 [1] HMOX1 💬 D05922 💬 Stannsoporfin [1] 254 💬
59 Ferroptosis 💬
 [1] TFRC 💬 D11812 💬 Pabinafusp alfa [1] 19 💬
60 Fluid shear stress and atherosclerosis 💬
 [1] ACVR2A 💬 D09670 💬 Sotatercept [2] 86, 284 💬
61 Fluid shear stress and atherosclerosis 💬
 [2] ACVR2A, ACVR2B 💬 D10620 💬 Bimagrumab [1] 15 💬
62 Fluid shear stress and atherosclerosis 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
63 Fluid shear stress and atherosclerosis 💬
 [1] BMPR2 💬 D03779 💬 Dibotermin alfa [1] 34 💬
64 Fluid shear stress and atherosclerosis 💬
 [4] CCL2, IL1A, IL1B, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
65 Fluid shear stress and atherosclerosis 💬
 [1] HMOX1 💬 D05922 💬 Stannsoporfin [1] 254 💬
66 Fluid shear stress and atherosclerosis 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [2] 49, 107 💬
67 Fluid shear stress and atherosclerosis 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
68 Fluid shear stress and atherosclerosis 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
69 Fluid shear stress and atherosclerosis 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
70 Fluid shear stress and atherosclerosis 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
71 Fluid shear stress and atherosclerosis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
72 Fluid shear stress and atherosclerosis 💬
 [2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
73 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 D03218 💬 Axitinib [1] 34 💬
74 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 D10062 💬 Cabozantinib [1] 34 💬
75 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 D08881 💬 Cediranib [1] 34 💬
76 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 D10481 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
77 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 D06272 💬 Sorafenib [2] 34, 86 💬
78 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 D08524 💬 Sorafenib [2] 34, 86 💬
79 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 D06402 💬 Sunitinib [2] 28, 34 💬
80 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 D08552 💬 Sunitinib [2] 28, 34 💬
81 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 D11772 💬 Tesevatinib [1] 67 💬
82 Fluid shear stress and atherosclerosis 💬
 [1] KEAP1 💬 D03846 💬 Dimethyl fumarate [5] 13, 49, 51, 86, 296 💬
83 Fluid shear stress and atherosclerosis 💬
 [1] MAP3K5 💬 D10988 💬 Selonsertib [1] 86 💬
84 Fluid shear stress and atherosclerosis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
85 Fluid shear stress and atherosclerosis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
86 Fluid shear stress and atherosclerosis 💬
 [1] NFE2L2 💬 D10964 💬 Omaveloxolone [1] 18 💬
87 Fluid shear stress and atherosclerosis 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
88 Fluid shear stress and atherosclerosis 💬
 [1] NQO1 💬 D00564 💬 Warfarin [13]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
89 Fluid shear stress and atherosclerosis 💬
 [1] NQO1 💬 D01280 💬 Warfarin [13]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
90 Fluid shear stress and atherosclerosis 💬
 [1] NQO1 💬 D08682 💬 Warfarin [13]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
91 Fluid shear stress and atherosclerosis 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
92 Fluid shear stress and atherosclerosis 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
93 Fluid shear stress and atherosclerosis 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [24]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
94 Fluid shear stress and atherosclerosis 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [24]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
95 Fluid shear stress and atherosclerosis 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
96 Fluid shear stress and atherosclerosis 💬
 [1] SRC 💬 D03252 💬 Bosutinib [2]  2 , 67 💬
97 Fluid shear stress and atherosclerosis 💬
 [1] SRC 💬 D03658 💬 Dasatinib [2] 51, 85 💬
98 Fluid shear stress and atherosclerosis 💬
 [1] SRC 💬 D06414 💬 Dasatinib [2] 51, 85 💬
99 Fluid shear stress and atherosclerosis 💬
 [1] SRC 💬 D09664 💬 Saracatinib [3]  6 , 89, 272 💬
100 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
101 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
102 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
103 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
104 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
105 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
106 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
107 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
108 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
109 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
110 Fluid shear stress and atherosclerosis 💬
 [1] VEGFA 💬 D09574 💬 Aflibercept [2] 90, 166 💬
111 Fluid shear stress and atherosclerosis 💬
 [1] VEGFA 💬 D06409 💬 Bevacizumab [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
112 Fluid shear stress and atherosclerosis 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
113 Focal adhesion 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
114 Focal adhesion 💬
 [1] BRAF 💬 D10064 💬 Dabrafenib [1] 34 💬
115 Focal adhesion 💬
 [5] BRAF, FLT4, KDR, PDGFRB, RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
116 Focal adhesion 💬
 [5] BRAF, FLT4, KDR, PDGFRB, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
117 Focal adhesion 💬
 [1] EGFR 💬 D03455 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
118 Focal adhesion 💬
 [1] EGFR 💬 D04023 💬 Erlotinib [1] 94 💬
119 Focal adhesion 💬
 [1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
120 Focal adhesion 💬
 [1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
121 Focal adhesion 💬
 [1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
122 Focal adhesion 💬
 [2] EGFR, ERBB2 💬 D04024 💬 Lapatinib [3] 34, 74, 75 💬
123 Focal adhesion 💬
 [2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
124 Focal adhesion 💬
 [4] EGFR, ERBB2, FLT4, KDR 💬 D11772 💬 Tesevatinib [1] 67 💬
125 Focal adhesion 💬
 [3] FLT1, FLT4, KDR 💬 D03218 💬 Axitinib [1] 34 💬
126 Focal adhesion 💬
 [3] FLT1, FLT4, KDR 💬 D08881 💬 Cediranib [1] 34 💬
127 Focal adhesion 💬
 [5] FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 D10481 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
128 Focal adhesion 💬
 [5] FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 D06402 💬 Sunitinib [2] 28, 34 💬
129 Focal adhesion 💬
 [5] FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 D08552 💬 Sunitinib [2] 28, 34 💬
130 Focal adhesion 💬
 [3] FYN, PDGFRB, SRC 💬 D03658 💬 Dasatinib [2] 51, 85 💬
131 Focal adhesion 💬
 [3] FYN, PDGFRB, SRC 💬 D06414 💬 Dasatinib [2] 51, 85 💬
132 Focal adhesion 💬
 [1] IGF1R 💬 D09925 💬 Linsitinib [1] 232 💬
133 Focal adhesion 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
134 Focal adhesion 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
135 Focal adhesion 💬
 [1] IGF1R 💬 D09680 💬 Teprotumumab [1] 51 💬
136 Focal adhesion 💬
 [1] ITGA4 💬 D06590 💬 Firategrast [1] 13 💬
137 Focal adhesion 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
138 Focal adhesion 💬
 [2] ITGA4, ITGB7 💬 D10540 💬 Abrilumab [2] 96, 97 💬
139 Focal adhesion 💬
 [2] ITGA4, ITGB7 💬 D08083 💬 Vedolizumab [3] 94, 96, 97 💬
140 Focal adhesion 💬
 [1] ITGB7 💬 D09901 💬 Etrolizumab [2] 96, 97 💬
141 Focal adhesion 💬
 [2] KDR, MET 💬 D10062 💬 Cabozantinib [1] 34 💬
142 Focal adhesion 💬
 [1] MAP2K1 💬 D10604 💬 Binimetinib [1] 34 💬
143 Focal adhesion 💬
 [1] MAP2K1 💬 D10405 💬 Cobimetinib [1] 280 💬
144 Focal adhesion 💬
 [1] MAP2K1 💬 D09666 💬 Selumetinib [1] 34 💬
145 Focal adhesion 💬
 [1] MAP2K1 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
146 Focal adhesion 💬
 [1] PDGFRA 💬 D01441 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
147 Focal adhesion 💬
 [1] PDGFRA 💬 D08066 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
148 Focal adhesion 💬
 [2] PDGFRA, PDGFRB 💬 D08953 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
149 Focal adhesion 💬
 [3] PGF, VEGFA, VEGFB 💬 D09574 💬 Aflibercept [2] 90, 166 💬
150 Focal adhesion 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
151 Focal adhesion 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
152 Focal adhesion 💬
 [2] ROCK1, ROCK2 💬 D07941 💬 Fasudil [4]  2 ,  5 ,  7 , 51 💬
153 Focal adhesion 💬
 [1] ROCK2 💬 D11815 💬 Belumosudil [1] 51 💬
154 Focal adhesion 💬
 [1] SRC 💬 D03252 💬 Bosutinib [2]  2 , 67 💬
155 Focal adhesion 💬
 [1] SRC 💬 D09664 💬 Saracatinib [3]  6 , 89, 272 💬
156 Focal adhesion 💬
 [1] VEGFA 💬 D06409 💬 Bevacizumab [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
157 Focal adhesion 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
158 Focal adhesion 💬
 [1] VWF 💬 D11160 💬 Caplacizumab [1] 64 💬
159 Folate biosynthesis 💬
 [1] ALPL 💬 D10595 💬 Asfotase alfa [1] 172 💬
160 Folate biosynthesis 💬
 [2] DHFR, DHFR2 💬 D00142 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
161 Folate biosynthesis 💬
 [2] DHFR, DHFR2 💬 D02115 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
162 Folate biosynthesis 💬
 [1] PAH 💬 D11077 💬 Pegvaliase [1] 240 💬
163 Folate biosynthesis 💬
 [2] TPH1, TPH2 💬 D09973 💬 Telotristat [1] 97 💬
164 FoxO signaling pathway 💬
 [1] BRAF 💬 D10064 💬 Dabrafenib [1] 34 💬
165 FoxO signaling pathway 💬
 [2] BRAF, RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
166 FoxO signaling pathway 💬
 [2] BRAF, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
167 FoxO signaling pathway 💬
 [1] EGFR 💬 D03455 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
168 FoxO signaling pathway 💬
 [1] EGFR 💬 D04023 💬 Erlotinib [1] 94 💬
169 FoxO signaling pathway 💬
 [1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
170 FoxO signaling pathway 💬
 [1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
171 FoxO signaling pathway 💬
 [1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
172 FoxO signaling pathway 💬
 [1] EGFR 💬 D04024 💬 Lapatinib [3] 34, 74, 75 💬
173 FoxO signaling pathway 💬
 [1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
174 FoxO signaling pathway 💬
 [1] EGFR 💬 D11772 💬 Tesevatinib [1] 67 💬
175 FoxO signaling pathway 💬
 [1] IGF1R 💬 D09925 💬 Linsitinib [1] 232 💬
176 FoxO signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
177 FoxO signaling pathway 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
178 FoxO signaling pathway 💬
 [1] IGF1R 💬 D09680 💬 Teprotumumab [1] 51 💬
179 FoxO signaling pathway 💬
 [2] IL10, IL6 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
180 FoxO signaling pathway 💬
 [1] IL6 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
181 FoxO signaling pathway 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
182 FoxO signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
183 FoxO signaling pathway 💬
 [1] INSR 💬 D04539 💬 Insulin detemir [1] 299 💬
184 FoxO signaling pathway 💬
 [1] INSR 💬 D03250 💬 Insulin glargine [1] 299 💬
185 FoxO signaling pathway 💬
 [1] INSR 💬 D00085 💬 Insulin human [2] 96, 156 💬
186 FoxO signaling pathway 💬
 [1] INSR 💬 D03230 💬 Insulin human [2] 96, 156 💬
187 FoxO signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
188 FoxO signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
189 FoxO signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
190 FoxO signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
191 FoxO signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
192 FoxO signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
193 FoxO signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
194 FoxO signaling pathway 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
195 FoxO signaling pathway 💬
 [1] PLK1 💬 D10154 💬 Rigosertib [1] 36 💬
196 FoxO signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [24]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
197 FoxO signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [24]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
198 FoxO signaling pathway 💬
 [1] S1PR1 💬 D11283 💬 Cenerimod [1] 49 💬
199 FoxO signaling pathway 💬
 [1] S1PR1 💬 D10001 💬 Fingolimod [3] 13, 14, 156 💬
200 FoxO signaling pathway 💬
 [1] S1PR1 💬 D11215 💬 Ponesimod [1] 13 💬
201 FoxO signaling pathway 💬
 [1] S1PR1 💬 D11460 💬 Siponimod [2] 13, 50 💬
202 FoxO signaling pathway 💬
 [2] S1PR1, S1PR4 💬 D10930 💬 Etrasimod [3] 96, 97, 98 💬
203 FoxO signaling pathway 💬
 [2] S1PR1, S1PR4 💬 D10968 💬 Ozanimod [3] 13, 96, 97 💬
204 FoxO signaling pathway 💬
 [3] TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab [4] 51, 85, 222, 274 💬

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