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 Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト) 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"    Synonyms (Drugs) were also searched for.

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49 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY
 On map, Yellow: Drug target, Red: Disease-related 
 KEGG GENES  KEGG DRUG  DrugBank   指定難病告示番号
 1  Acute myeloid leukemia 
 2 genes, 1 drug (DrugBank) and 5 diseases shown 
 2件: PML, RARA   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 2  Adrenergic signaling in cardiomyocytes 
 6 genes, 4 drugs (DrugBank) and 20 diseases shown 
 5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 1件: SCN5A   D00252   Carbamazepine   1件: 231 
 D00358   Lidocaine   10件: 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 3  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank) and 9 diseases shown 
 1件: ADRA1A   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 4  Arachidonic acid metabolism 
 2 genes, 2 drugs (DrugBank) and 16 diseases shown 
 2件: PTGS1, PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 5  C-type lectin receptor signaling pathway 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 6  Calcium signaling pathway 
 6 genes, 2 drugs (DrugBank) and 18 diseases shown 
 6件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 7  cAMP signaling pathway 
 2 genes, 2 drugs (DrugBank) and 18 diseases shown 
 2件: ADRB1, ADRB2   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 8  cGMP-PKG signaling pathway 
 10 genes, 3 drugs (DrugBank) and 20 diseases shown 
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 1件: OPRD1   D03783   Oxycodone   7件: 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 9  Chemical carcinogenesis 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 10  Dilated cardiomyopathy (DCM) 
 1 gene, 1 drug (DrugBank) and 9 diseases shown 
 1件: ADRB1   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 11  Dopaminergic synapse 
 1 gene, 2 drugs (DrugBank) and 10 diseases shown 
 1件: SCN1A   D00252   Carbamazepine   1件: 231 
 D00358   Lidocaine   10件: 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 12  Endocytosis 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: PML   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 13  Estrogen signaling pathway 
 2 genes, 3 drugs (DrugBank) and 13 diseases shown 
 1件: OPRM1   D00320   Fentanyl   5件: 46, 70, 85, 215, 231 
 D01399 
 D03783   Oxycodone   7件: 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 1件: RARA   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 14  GABAergic synapse 
 16 genes, 2 drugs (DrugBank) and 10 diseases shown 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00365   Lorazepam   1件: 231 
 D00550   Midazolam   10件: 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 15  Gap junction 
 1 gene, 1 drug (DrugBank) and 9 diseases shown 
 1件: ADRB1   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 16  Gastric cancer 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: RARB   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 17  Herpes simplex virus 1 infection 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: PML   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 18  Human cytomegalovirus infection 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 19  Human papillomavirus infection 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 20  IL-17 signaling pathway 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 21  Influenza A 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: PML   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 22  Kaposi sarcoma-associated herpesvirus infection 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 23  Leishmaniasis 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 24  Metabolic pathways 
 2 genes, 2 drugs (DrugBank) and 16 diseases shown 
 2件: PTGS1, PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 25  MicroRNAs in cancer 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 26  Morphine addiction 
 17 genes, 4 drugs (DrugBank) and 13 diseases shown 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00365   Lorazepam   1件: 231 
 D00550   Midazolam   10件: 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 1件: OPRM1   D00320   Fentanyl   5件: 46, 70, 85, 215, 231 
 D01399 
 D03783   Oxycodone   7件: 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 27  Neuroactive ligand-receptor interaction 
 28 genes, 6 drugs (DrugBank) and 23 diseases shown 
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00365   Lorazepam   1件: 231 
 D00550   Midazolam   10件: 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 3件: OPRD1, OPRK1, OPRM1   D03783   Oxycodone   7件: 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 1件: OPRM1   D00320   Fentanyl   5件: 46, 70, 85, 215, 231 
 D01399 
 28  NF-kappa B signaling pathway 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 29  Nicotine addiction 
 16 genes, 2 drugs (DrugBank) and 10 diseases shown 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00365   Lorazepam   1件: 231 
 D00550   Midazolam   10件: 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 30  Non-small cell lung cancer 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: RARB   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 31  Ovarian steroidogenesis 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 32  Oxytocin signaling pathway 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 33  Pathways in cancer 
 4 genes, 3 drugs (DrugBank) and 20 diseases shown 
 3件: PML, RARA, RARB   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 34  Platelet activation 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS1   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 35  Regulation of lipolysis in adipocytes 
 5 genes, 4 drugs (DrugBank) and 25 diseases shown 
 3件: ADRB1, ADRB2, ADRB3   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 2件: PTGS1, PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 36  Renin secretion 
 3 genes, 2 drugs (DrugBank) and 18 diseases shown 
 3件: ADRB1, ADRB2, ADRB3   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 37  Retrograde endocannabinoid signaling 
 17 genes, 4 drugs (DrugBank) and 20 diseases shown 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00365   Lorazepam   1件: 231 
 D00550   Midazolam   10件: 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 38  Salivary secretion 
 6 genes, 2 drugs (DrugBank) and 18 diseases shown 
 6件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 39  Serotonergic synapse 
 10 genes, 5 drugs (DrugBank) and 20 diseases shown 
 3件: GABRB1, GABRB2, GABRB3   D00365   Lorazepam   1件: 231 
 D00550   Midazolam   10件: 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 5件: HTR3A, HTR3B, HTR3C, HTR3D, HTR3E   D00456   Ondansetron   1件: 231 
 D00678 
 2件: PTGS1, PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 40  Small cell lung cancer 
 2 genes, 3 drugs (DrugBank) and 20 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 1件: RARB   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 41  Sphingolipid signaling pathway 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 
 1件: OPRD1   D03783   Oxycodone   7件: 6, 13, 46, 70, 226, 231, 298 
 D05312 
 D05462 
 42  Taste transduction 
 14 genes, 5 drugs (DrugBank) and 15 diseases shown 
 6件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6   D00365   Lorazepam   1件: 231 
 D00550   Midazolam   10件: 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 5件: HTR3A, HTR3B, HTR3C, HTR3D, HTR3E   D00456   Ondansetron   1件: 231 
 D00678 
 3件: SCN2A, SCN3A, SCN9A   D00252   Carbamazepine   1件: 231 
 D00358   Lidocaine   10件: 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 
 D02086 
 D08127 
 43  Th17 cell differentiation 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: RARA   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 44  Thermogenesis 
 1 gene, 1 drug (DrugBank) and 9 diseases shown 
 1件: ADRB3   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 45  TNF signaling pathway 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 46  Transcriptional misregulation in cancer 
 2 genes, 1 drug (DrugBank) and 5 diseases shown 
 2件: PML, RARA   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 47  Ubiquitin mediated proteolysis 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: PML   D00094   Tretinoin   5件: 2, 63, 75, 94, 231 
 48  Vascular smooth muscle contraction 
 3 genes, 1 drug (DrugBank) and 9 diseases shown 
 3件: ADRA1A, ADRA1B, ADRA1D   D00095   Epinephrine   9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 
 D00996 
 D02149 
 49  VEGF signaling pathway 
 1 gene, 2 drugs (DrugBank) and 16 diseases shown 
 1件: PTGS2   D00217   Acetaminophen   13件: 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   10件: 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 

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