Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Purine metabolism 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Amyl nitrite 💬 Amyl Nitrite 1件: 58 💬
2 Purine metabolism 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
3 Purine metabolism 💬
 1件: GUCY2C 💬 Linaclotide 💬 Linaclotide 2件:  6 , 97 💬
4 Purine metabolism 💬
 1件: HPRT1 💬 Mercaptopurine 💬 Mercaptopurine 4件: 65, 96, 97, 164 💬
5 Purine metabolism 💬
 1件: HPRT1 💬 Mercaptopurine 💬 Mercaptopurine 4件: 65, 96, 97, 164 💬
6 Purine metabolism 💬
 1件: HPRT1 💬 Tioguanine 💬 Tioguanine 2件: 13, 37 💬
7 Purine metabolism 💬
 2件: IMPDH1, IMPDH2 💬 Mizoribine 💬 Mizoribine 8件: 46, 49, 51, 53, 66, 94, 222, 224 💬
8 Purine metabolism 💬
 2件: IMPDH1, IMPDH2 💬 Mycophenolate mofetil 💬 Mycophenolate mofetil 34件:  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
9 Purine metabolism 💬
 2件: IMPDH1, IMPDH2 💬 Mycophenolic acid 💬 Mycophenolic acid 36件:  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
10 Purine metabolism 💬
 1件: NPR1 💬 Nesiritide 💬 Nesiritide 2件: 46, 58 💬
11 Purine metabolism 💬
 2件: NPR1, NPR2 💬 Erythrityl tetranitrate 💬 Erythrityl tetranitrate 1件: 46 💬
12 Purine metabolism 💬
 1件: NPR2 💬 Vosoritide 💬 Vosoritide 1件: 276 💬
13 Purine metabolism 💬
 16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline 1件: 63 💬
14 Purine metabolism 💬
 16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine 1件: 246 💬
15 Purine metabolism 💬
 16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate 1件: 226 💬
16 Purine metabolism 💬
 16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline 2件: 236, 299 💬
17 Purine metabolism 💬
 16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline 2件: 236, 299 💬
18 Purine metabolism 💬
 9件: PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine 💬 Caffeine 8件:  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
19 Purine metabolism 💬
 9件: PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine hydrate 💬 Caffeine 8件:  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
20 Purine metabolism 💬
 2件: PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol 3件: 46, 51, 70 💬
21 Purine metabolism 💬
 2件: PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan 1件:  2  💬
22 Purine metabolism 💬
 2件: PDE3A, PDE3B 💬 Milrinone 💬 Milrinone 1件: 294 💬
23 Purine metabolism 💬
 6件: PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Ibudilast 💬 Ibudilast 2件:  2 , 13 💬
24 Purine metabolism 💬
 4件: PDE4A, PDE4B, PDE4C, PDE4D 💬 Apremilast 💬 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271 💬
25 Purine metabolism 💬
 4件: PDE4A, PDE4B, PDE4C, PDE4D 💬 Roflumilast 💬 Roflumilast 4件: 84, 97, 206, 299 💬
26 Purine metabolism 💬
 4件: PDE4A, PDE4B, PDE4C, PDE4D 💬 Rolipram 💬 Rolipram 2件:  8 , 13 💬
27 Purine metabolism 💬
 2件: PDE4A, PDE5A 💬 Dipyridamole 💬 Dipyridamole 6件: 46, 49, 51, 66, 96, 224 💬
28 Purine metabolism 💬
 1件: PDE4D 💬 Zatolmilast 💬 Zatolmilast 1件: 206 💬
29 Purine metabolism 💬
 1件: PDE5A 💬 Sildenafil 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
30 Purine metabolism 💬
 1件: PDE5A 💬 Tadalafil 💬 Tadalafil 7件:  6 , 51, 75, 84, 86, 113, 210 💬
31 Purine metabolism 💬
 1件: PDE5A 💬 Udenafil 💬 Udenafil 2件: 86, 210 💬
32 Purine metabolism 💬
 1件: PDE5A 💬 Vardenafil 💬 Vardenafil 3件: 13, 86, 299 💬
33 Purine metabolism 💬
 1件: RRM1 💬 Cladribine 💬 Cladribine 3件: 11, 13, 94 💬
34 Purine metabolism 💬
 1件: RRM1 💬 Clofarabine 💬 Clofarabine 5件: 19, 20, 60, 234, 326 💬
35 Purine metabolism 💬
 1件: RRM1 💬 Fludarabine 💬 Fludarabine 20件: 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬
36 Purine metabolism 💬
 1件: RRM2 💬 Hydroxyurea 💬 Hydroxyurea 8件:  3 , 13, 19, 20, 65, 85, 86, 284 💬
37 Purine metabolism 💬
 1件: XDH 💬 Allopurinol 💬 Allopurinol 7件:  6 , 46, 57, 60, 66, 96, 97 💬
38 Purine metabolism 💬
 1件: XDH 💬 Febuxostat 💬 Febuxostat 3件:  2 ,  6 , 13 💬