Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Calcium signaling pathway 💬
 [6] FLT1, FLT4, KDR, PDGFRA, PDGFRB, RET 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
2 Calcium signaling pathway 💬
 [4] FLT4, KDR, PDGFRB, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
3 Central carbon metabolism in cancer 💬
 [5] FLT3, KIT, PDGFRA, PDGFRB, RET 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
4 Central carbon metabolism in cancer 💬
 [5] FLT3, KIT, PDGFRB, RAF1, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
5 Non-small cell lung cancer 💬
 [3] BRAF, RAF1, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
6 Non-small cell lung cancer 💬
 [1] RET 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
7 Pathways in cancer 💬
 [7] BRAF, FLT3, FLT4, KIT, PDGFRB, RAF1, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
8 Pathways in cancer 💬
 [7] CSF1R, FLT3, FLT4, KIT, PDGFRA, PDGFRB, RET 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
9 Protein processing in endoplasmic reticulum 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
10 Protein processing in endoplasmic reticulum 💬
 [1] MAP3K5 💬 Selonsertib 💬 Selonsertib [1] 86 💬
11 Protein processing in endoplasmic reticulum 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
12 Retinol metabolism 💬
 [3] ADH1A, ADH1B, ADH1C 💬 Fomepizole 💬 Fomepizole [1] 301 💬
13 Retrograde endocannabinoid signaling 💬
 [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
14 Retrograde endocannabinoid signaling 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
15 Retrograde endocannabinoid signaling 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
16 Retrograde endocannabinoid signaling 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
17 Retrograde endocannabinoid signaling 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
18 Retrograde endocannabinoid signaling 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
19 Retrograde endocannabinoid signaling 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
20 Retrograde endocannabinoid signaling 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
21 Retrograde endocannabinoid signaling 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
22 Retrograde endocannabinoid signaling 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
23 Retrograde endocannabinoid signaling 💬
 [24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
24 Retrograde endocannabinoid signaling 💬
 [1] CNR1 💬 Cannabidiol 💬 Cannabidiol [20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
25 Retrograde endocannabinoid signaling 💬
 [1] CNR1 💬 Dronabinol 💬 Dronabinol [8]  2 ,  8 , 13, 36, 46, 96, 271, 298 💬
26 Retrograde endocannabinoid signaling 💬
 [1] CNR1 💬 Nabilone 💬 Nabilone [3]  6 , 13, 127 💬
27 Retrograde endocannabinoid signaling 💬
 [1] CNR1 💬 Rimonabant 💬 Rimonabant [1] 193 💬
28 Retrograde endocannabinoid signaling 💬
 [1] GABRA1 💬 Etomidate 💬 Etomidate [1]  6  💬
29 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Alprazolam 💬 Alprazolam [2]  8 , 75 💬
30 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Brexanolone 💬 Brexanolone [1] 205 💬
31 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clobazam 💬 Clobazam [2] 140, 144 💬
32 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clonazepam 💬 Clonazepam [1]  6  💬
33 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Delorazepam 💬 Delorazepam [3]  6 , 46, 97 💬
34 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Diazepam 💬 Diazepam [3] 46, 155, 298 💬
35 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Eszopiclone 💬 Eszopiclone [3]  6 , 13, 46 💬
36 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
37 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Gaboxadol 💬 Gaboxadol [2] 201, 206 💬
38 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
39 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Lorazepam 💬 Lorazepam [1] 36 💬
40 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Midazolam 💬 Midazolam [12]  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
41 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Propofol 💬 Propofol [9]  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
42 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Zolpidem 💬 Zolpidem [3]  5 ,  6 , 46 💬
43 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Zopiclone 💬 Zopiclone [1]  6  💬
44 Retrograde endocannabinoid signaling 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
45 Retrograde endocannabinoid signaling 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
46 Retrograde endocannabinoid signaling 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
47 Retrograde endocannabinoid signaling 💬
 [2] KCNJ3, KCNJ5 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
48 Retrograde endocannabinoid signaling 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
49 Retrograde endocannabinoid signaling 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
50 Retrograde endocannabinoid signaling 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
51 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Aceclofenac 💬 Aceclofenac [1] 46 💬
52 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
53 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Aspirin 💬 Acetylsalicylic acid [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
54 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Celecoxib 💬 Celecoxib [10]  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
55 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
56 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Diflunisal 💬 Diflunisal [1] 28 💬
57 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Etodolac 💬 Etodolac [1] 46 💬
58 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Etoricoxib 💬 Etoricoxib [2] 46, 271 💬
59 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Flurbiprofen 💬 Flurbiprofen [3] 13, 21, 46 💬
60 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Ibuprofen 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬
61 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Indomethacin 💬 Indomethacin [3] 225, 271, 298 💬
62 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Ketoprofen 💬 Ketoprofen [1] 46 💬
63 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Ketorolac 💬 Ketorolac [2] 70, 226 💬
64 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Loxoprofen 💬 Loxoprofen [2] 46, 271 💬
65 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Lumiracoxib 💬 Lumiracoxib [1] 46 💬
66 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Meloxicam 💬 Meloxicam [4] 46, 49, 271, 296 💬
67 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Naproxen 💬 Naproxen [4] 13, 46, 107, 271 💬
68 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Nimesulide 💬 Nimesulide [1] 46 💬
69 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Parecoxib 💬 Parecoxib [2] 46, 271 💬
70 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Rofecoxib 💬 Rofecoxib [1] 46 💬
71 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Salsalate 💬 Salsalate [1]  5  💬
72 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Sulindac 💬 Sulindac [1] 206 💬
73 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Tolfenamic acid 💬 Tolfenamic acid [1]  5  💬
74 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Valdecoxib 💬 Valdecoxib [1] 46 💬
75 Thyroid cancer 💬
 [2] BRAF, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
76 Thyroid cancer 💬
 [1] RET 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬

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