Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 MAPK14 3件: VEGF signaling pathway, Yersinia infection, Tuberculosis D09639 Losmapimod 2件: 113, 222
2 MAPK14 3件: VEGF signaling pathway, Yersinia infection, Tuberculosis D10959 Neflamapimod 1件: 8
3 IFNA1 1件: Tuberculosis D09662 Rontalizumab 1件: 49
4 IFNA1 1件: Tuberculosis D09668 Sifalimumab 1件: 49
5 IFNA2 1件: Tuberculosis D09662 Rontalizumab 1件: 49
6 IFNA2 1件: Tuberculosis D09668 Sifalimumab 1件: 49
7 IFNA4 1件: Tuberculosis D09662 Rontalizumab 1件: 49
8 IFNA4 1件: Tuberculosis D09668 Sifalimumab 1件: 49
9 IFNA5 1件: Tuberculosis D09662 Rontalizumab 1件: 49
10 IFNA5 1件: Tuberculosis D09668 Sifalimumab 1件: 49
11 IFNA6 1件: Tuberculosis D09662 Rontalizumab 1件: 49
12 IFNA6 1件: Tuberculosis D09668 Sifalimumab 1件: 49
13 IFNA7 1件: Tuberculosis D09662 Rontalizumab 1件: 49
14 IFNA7 1件: Tuberculosis D09668 Sifalimumab 1件: 49
15 IFNA8 1件: Tuberculosis D09662 Rontalizumab 1件: 49
16 IFNA8 1件: Tuberculosis D09668 Sifalimumab 1件: 49
17 IFNA10 1件: Tuberculosis D09662 Rontalizumab 1件: 49
18 IFNA10 1件: Tuberculosis D09668 Sifalimumab 1件: 49
19 IFNA13 1件: Tuberculosis D09662 Rontalizumab 1件: 49
20 IFNA13 1件: Tuberculosis D09668 Sifalimumab 1件: 49
21 IFNA14 1件: Tuberculosis D09662 Rontalizumab 1件: 49
22 IFNA14 1件: Tuberculosis D09668 Sifalimumab 1件: 49
23 IFNA16 1件: Tuberculosis D09662 Rontalizumab 1件: 49
24 IFNA16 1件: Tuberculosis D09668 Sifalimumab 1件: 49
25 IFNA17 1件: Tuberculosis D09662 Rontalizumab 1件: 49
26 IFNA17 1件: Tuberculosis D09668 Sifalimumab 1件: 49
27 IFNA21 1件: Tuberculosis D09662 Rontalizumab 1件: 49
28 IFNA21 1件: Tuberculosis D09668 Sifalimumab 1件: 49
29 IFNG 2件: Type I diabetes mellitus, Tuberculosis D04242 Fontolizumab 1件: 46
30 IFNG 2件: Type I diabetes mellitus, Tuberculosis D11120 Emapalumab 3件: 49, 65, 107
31 IFNGR1 1件: Tuberculosis D00747 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326
32 IFNGR2 1件: Tuberculosis D00747 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326
33 IL1A 2件: Type I diabetes mellitus, Tuberculosis D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
34 IL1A 2件: Type I diabetes mellitus, Tuberculosis D06635 Rilonacept 4件: 51, 106, 107, 266
35 IL1A 2件: Type I diabetes mellitus, Tuberculosis D11253 Bermekimab 1件: 51
36 IL1B 3件: Type I diabetes mellitus, Yersinia infection, Tuberculosis D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
37 IL1B 3件: Type I diabetes mellitus, Yersinia infection, Tuberculosis D06635 Rilonacept 4件: 51, 106, 107, 266
38 IL1B 3件: Type I diabetes mellitus, Yersinia infection, Tuberculosis D09315 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
39 IL1B 3件: Type I diabetes mellitus, Yersinia infection, Tuberculosis D09911 Gevokizumab 4件: 41, 50, 56, 269
40 IL6 3件: Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, Tuberculosis D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
41 IL6 3件: Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, Tuberculosis D08976 Pomalidomide 5件: 28, 51, 85, 227, 331
42 IL6 3件: Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, Tuberculosis D09669 Siltuximab 2件: 28, 331
43 IL6 3件: Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, Tuberculosis D10080 Sirukumab 2件: 41, 46
44 IL6 3件: Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, Tuberculosis D12487 Olokizumab 2件: 46, 96
45 IL10 3件: Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, Tuberculosis D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
46 IL12A 2件: Type I diabetes mellitus, Tuberculosis D09214 Ustekinumab 16件: 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
47 IL12B 2件: Type I diabetes mellitus, Tuberculosis D09214 Ustekinumab 16件: 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
48 JAK1 2件: Tuberculosis, Viral carcinogenesis D09959 Ruxolitinib 3件: 60, 65, 228
49 JAK1 2件: Tuberculosis, Viral carcinogenesis D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
50 JAK1 2件: Tuberculosis, Viral carcinogenesis D10308 Baricitinib 13件: 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325
51 JAK1 2件: Tuberculosis, Viral carcinogenesis D10653 Peficitinib 1件: 46
52 JAK1 2件: Tuberculosis, Viral carcinogenesis D10871 Filgotinib 6件: 46, 53, 96, 97, 222, 271
53 JAK1 2件: Tuberculosis, Viral carcinogenesis D10944 Itacitinib 4件: 46, 51, 97, 228
54 JAK1 2件: Tuberculosis, Viral carcinogenesis D10994 Upadacitinib 8件: 40, 41, 46, 49, 96, 97, 107, 271
55 JAK1 2件: Tuberculosis, Viral carcinogenesis D11400 Abrocitinib 1件: 84
56 JAK2 1件: Tuberculosis D09959 Ruxolitinib 3件: 60, 65, 228
57 JAK2 1件: Tuberculosis D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
58 JAK2 1件: Tuberculosis D10308 Baricitinib 13件: 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325
59 JAK2 1件: Tuberculosis D10653 Peficitinib 1件: 46
60 NFKB1 3件: Yersinia infection, Tuberculosis, Viral carcinogenesis D01146 Iguratimod 5件: 46, 51, 53, 271, 300
61 IL23A 1件: Tuberculosis D09214 Ustekinumab 16件: 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
62 IL23A 1件: Tuberculosis D10400 Tildrakizumab 2件: 162, 271
63 IL23A 1件: Tuberculosis D10438 Guselkumab 5件: 37, 41, 51, 96, 97
64 IL23A 1件: Tuberculosis D10912 Brazikumab 2件: 96, 97
65 IL23A 1件: Tuberculosis D11052 Risankizumab 4件: 37, 96, 97, 271
66 IL23A 1件: Tuberculosis D11123 Mirikizumab 3件: 37, 96, 97
67 TLR9 1件: Tuberculosis D12275 Cobitolimod 1件: 97
68 PPP3CA 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
69 PPP3CA 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
70 PPP3CA 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D05480 Pimecrolimus 1件: 160
71 PPP3CA 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
72 PPP3CA 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D09033 Voclosporin 2件: 49, 222
73 PPP3CB 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
74 PPP3CB 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
75 PPP3CB 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D05480 Pimecrolimus 1件: 160
76 PPP3CB 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
77 PPP3CB 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D09033 Voclosporin 2件: 49, 222
78 PPP3CC 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
79 PPP3CC 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
80 PPP3CC 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D05480 Pimecrolimus 1件: 160
81 PPP3CC 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
82 PPP3CC 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D09033 Voclosporin 2件: 49, 222
83 PPP3R1 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
84 PPP3R1 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
85 PPP3R1 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D05480 Pimecrolimus 1件: 160
86 PPP3R1 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
87 PPP3R1 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D09033 Voclosporin 2件: 49, 222
88 PPP3R2 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
89 PPP3R2 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
90 PPP3R2 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D05480 Pimecrolimus 1件: 160
91 PPP3R2 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
92 PPP3R2 3件: Wnt signaling pathway, VEGF signaling pathway, Tuberculosis D09033 Voclosporin 2件: 49, 222
93 MAPK11 3件: VEGF signaling pathway, Yersinia infection, Tuberculosis D09639 Losmapimod 2件: 113, 222
94 MAPK11 3件: VEGF signaling pathway, Yersinia infection, Tuberculosis D10959 Neflamapimod 1件: 8
95 MAPK13 3件: VEGF signaling pathway, Yersinia infection, Tuberculosis D09639 Losmapimod 2件: 113, 222
96 MAPK13 3件: VEGF signaling pathway, Yersinia infection, Tuberculosis D10959 Neflamapimod 1件: 8
97 RAF1 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Tuberculosis D08524 Sorafenib 2件: 34, 86
98 BCL2 1件: Tuberculosis D10679 Venetoclax 1件: 28
99 RELA 3件: Yersinia infection, Tuberculosis, Viral carcinogenesis D12181 Edasalonexent 1件: 113
100 MAPK12 3件: VEGF signaling pathway, Yersinia infection, Tuberculosis D09639 Losmapimod 2件: 113, 222
101 MAPK12 3件: VEGF signaling pathway, Yersinia infection, Tuberculosis D10959 Neflamapimod 1件: 8
102 SRC 4件: VEGF signaling pathway, Yersinia infection, Tuberculosis, Viral carcinogenesis D03252 Bosutinib 2件: 2, 67
103 SRC 4件: VEGF signaling pathway, Yersinia infection, Tuberculosis, Viral carcinogenesis D03658 Dasatinib 2件: 51, 85
104 SRC 4件: VEGF signaling pathway, Yersinia infection, Tuberculosis, Viral carcinogenesis D06414 Dasatinib 2件: 51, 85
105 SRC 4件: VEGF signaling pathway, Yersinia infection, Tuberculosis, Viral carcinogenesis D09664 Saracatinib 3件: 6, 89, 272
106 SYK 2件: Tuberculosis, Viral carcinogenesis D09347 Fostamatinib 4件: 46, 49, 61, 66
107 TGFB1 1件: Tuberculosis D09620 Fresolimumab 3件: 51, 85, 222
108 TGFB2 1件: Tuberculosis D09620 Fresolimumab 3件: 51, 85, 222
109 TGFB3 1件: Tuberculosis D09620 Fresolimumab 3件: 51, 85, 222
110 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D00742 Etanercept 16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
111 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D00754 Thalidomide 20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
112 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
113 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D02597 Adalimumab 17件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
114 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D02598 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
115 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D03441 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271
116 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D04358 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271
117 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D04687 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331
118 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D05393 Pegsunercept 1件: 46
119 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D08976 Pomalidomide 5件: 28, 51, 85, 227, 331
120 TNF 5件: Viral protein interaction with cytokine and cytokine receptor, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Tuberculosis D09944 Ozoralizumab 1件: 46
121 C3 2件: Tuberculosis, Viral carcinogenesis D11613 Pegcetacoplan 4件: 2, 61, 62, 222
122 VDR 1件: Tuberculosis D00122 Calcifediol 2件: 113, 299
123 VDR 1件: Tuberculosis D00129 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326
124 VDR 1件: Tuberculosis D00187 Ergocalciferol 6件: 46, 49, 84, 96, 97, 299
125 VDR 1件: Tuberculosis D00188 Cholecalciferol 24件: 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299
126 VDR 1件: Tuberculosis D00299 Dihydrotachysterol 2件: 6, 85
127 VDR 1件: Tuberculosis D00930 Paricalcitol 5件: 19, 66, 218, 238, 298
128 VDR 1件: Tuberculosis D01125 Calcipotriol 2件: 36, 51
129 VDR 1件: Tuberculosis D01518 Alfacalcidol 8件: 41, 46, 49, 50, 96, 107, 235, 238
130 VDR 1件: Tuberculosis D07578 Eldecalcitol 1件: 46
131 CASP9 3件: VEGF signaling pathway, Tuberculosis, Viral myocarditis D11195 Rimiducid 6件: 19, 60, 65, 284, 285, 326
132 CD74 1件: Tuberculosis D08944 Milatuzumab 1件: 49