Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Ianalumab [1] Ianalumab[1] D12151 [1] TNFRSF13C 💬[5] Cytokine-cytokine receptor interaction, Human T-cell leukemia virus 1 infection, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Primary immunodeficiency 💬[7] 35, 46, 49, 53, 61, 63, 95
2 Ibandronate [2] Ibandronate; Ibandronic acid---[3] 46, 49, 274
3 Ibrutinib [1] Ibrutinib[1] D10223 [1] BTK 💬[7] B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency 💬[3] 28, 60, 61
4 Ibudilast [1] IBUDILAST[1] D01385 [8] CYSLTR1,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PTGIR 💬		[16] Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action, Platelet activation, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 2, 13
5 Ibuprofen [2] IBUPROFEN; IBUPROFEN 200MG[1] D00126 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[7] 13, 46, 65, 107, 113, 271, 299
6 Icerguastat [1] Icerguastat---[1] 2
7 Icosapent [2] Eicosapentaenoic acid; Icosapent[1] D08061 --[11] 8, 46, 48, 49, 96, 97, 113, 296, 297, 301, 338
8 Icosapent ethyl [2] Ethyl-EPA; Icosapent[1] D01892 --[2] 8, 296
9 Icotinib [1] Icotinib[1] D11251 [1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[1] 34
10 Idebenone [2] Idebenone; Raxone[1] D01750 --[6] 6, 8, 13, 18, 113, 302
11 Idursulfase [4] Elaprase; Iduronate 2-sulfatase; IDURSULFASA; IDURSULFASE[1] D04499 [1] IDS 💬[3] Glycosaminoglycan degradation, Lysosome, Metabolic pathways 💬[1] 19
12 Idursulfase beta [3] Hunterase; Iduronate 2-sulfatase; Idursulfase beta[1] D11025 [1] IDS 💬[3] Glycosaminoglycan degradation, Lysosome, Metabolic pathways 💬[1] 19
13 Ifetroban [1] Ifetroban[1] D04500 [1] TBXA2R 💬[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation 💬[2] 85, 113
14 Ifosfamide [1] Ifosfamide[1] D00343 --[1] 34
15 Iguratimod [1] Iguratimod[1] D01146 [1] NFKB1 💬[76] AGE-RAGE signaling pathway in diabetic complications, Acute myeloid leukemia, Adipocytokine signaling pathway, Alcoholic liver disease, Alzheimer disease, Amoebiasis, Antifolate resistance, Apoptosis, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, Cocaine addiction, Coronavirus disease - COVID-19, Cytosolic DNA-sensing pathway, Diabetic cardiomyopathy, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fluid shear stress and atherosclerosis, HIF-1 signaling pathway, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, Longevity regulating pathway, MAPK signaling pathway, Measles, MicroRNAs in cancer, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prolactin signaling pathway, Prostate cancer, RIG-I-like receptor signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Salmonella infection, Shigellosis, Small cell lung cancer, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Viral carcinogenesis, Yersinia infection, cAMP signaling pathway 💬[5] 46, 51, 53, 271, 300
16 Iloperidone [1] Iloperidone[1] D02666 [4] DRD2,
HTR2A,
HTR2B,
HTR2C 💬		[11] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[1] 6
17 Iloprost [2] ILOPROST; Ventavis[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[4] 51, 84, 85, 86
18 Imatinib [4] Gleevec; GLIVEC; Imatinib; Imatinib mesylate[1] D08066 [3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
19 IMCY-0141 [1] IMCY-0141---[1] 13
20 Imidacloprid [0] ---[5] 19, 20, 125, 234, 326
21 Imidapril [1] Imidapril[1] D08068 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 67
22 Imiglucerase [3] CEREZYME; IMIGLUCERASA; IMIGLUCERASE[1] D03020 [1] GBA1 💬[4] Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism 💬[1] 19
23 Imipenem [1] IMIPENEM[2] D00206 ,
D04515 		--[2] 60, 299
24 Imiquimod [1] Imiquimod[1] D02500 [1] TLR7 💬[5] Coronavirus disease - COVID-19, Influenza A, Measles, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway 💬[2] 34, 51
25 Imlifidase [2] HMED-IdeS; IdeS[1] D11470 --[2] 64, 221
26 Implitapide [1] Implitapide---[1] 79
27 Imrecoxib [1] Imrecoxib---[1] 271
28 Imsidolimab [1] Imsidolimab[1] D11892 [1] IL1RL2 💬[1] Cytokine-cytokine receptor interaction 💬[1] 37
29 Inclisiran [3] ALN-PCSSC; Inclisiran; Leqvio[1] D11931 [1] PCSK9 💬[1] Cholesterol metabolism 💬[1] 79
30 Indapamide [1] Indapamide[1] D00345 [1] SLC12A3 💬-[1] 13
31 Indian frankincense [2] Boswellia Serrata; Boswellia Serrata Extract---[1] 13
32 Indigo [1] Indigo---[3] 97, 289, 300
33 Indinavir [1] Indinavir[1] D03833 --[1] 265
34 Indium [1] Indium---[3] 28, 84, 299
35 Indocyanine green [1] Indocyanine green[1] D01342 --[8] 22, 46, 51, 96, 235, 278, 291, 296
36 Indole [1] Indole---[1] 51
37 Indomethacin [2] INDOMETACIN; Indomethacin[1] D00141 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[3] 225, 271, 298
38 Indopan [0] ---[4] 8, 46, 97, 321
39 Inebilizumab [2] Inebilizumab; Uplizna[1] D11757 [1] CD19 💬[5] B cell receptor signaling pathway, Epstein-Barr virus infection, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Primary immunodeficiency 💬[4] 11, 13, 51, 300
40 Infigratinib [1] INFIGRATINIB[1] D11589 [3] FGFR1,
FGFR2,
FGFR3 💬		[21] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, EGFR tyrosine kinase inhibitor resistance, Endocytosis, Gastric cancer, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬[1] 276
41 Infliximab [6] Flixabi; Inflectra; Infliximab; REMICADE; Remsima; Zessly[1] D02598 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
42 Influenza A virus A/Brisbane/59/2007 (H1N1) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
43 Influenza A virus A/California/7/2009 (H1N1) live (attenuated) antigen [1] FluMist---[1] 299
44 Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
45 Influenza A virus A/Perth/16/2009 (H3N2) live (attenuated) antigen [1] FluMist---[1] 299
46 Influenza A virus A/South Dakota/6/2007 (H1N1) live (attenuated) antigen [1] FluMist---[1] 299
47 Influenza A virus A/Switzerland/9715293/2013 NIB-88 (H3N2) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
48 Influenza A virus A/Texas/50/2012 X-223A (H3N2) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
49 Influenza A virus A/Uruguay/716/2007(H3N2) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
50 Influenza A virus A/Uruguay/716/2007(H3N2) live (attenuated) antigen [1] FluMist---[1] 299
51 Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
52 Influenza A virus A/Victoria/361/2011 (H3N2) live (attenuated) antigen [1] FluMist---[1] 299
53 Influenza A virus A/Victoria/361/2011 IVR-165 (H3N2) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
54 Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
55 Influenza B virus B/Brisbane/60/2008 live (attenuated) antigen [1] FluMist---[1] 299
56 Influenza B virus B/Massachusetts/2/2012 antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
57 Influenza B virus B/Massachusetts/2/2012 BX-51B antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
58 Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
59 Influenza B virus B/Texas/6/2011 antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
60 Influenza B virus B/Wisconsin/1/2010 live (attenuated) antigen [1] FluMist---[1] 299
61 Influenza virus type A (H1N1) [1] FluMist---[1] 299
62 Influenza virus type A (H3N2) [1] FluMist---[1] 299
63 Influenza virus type B [1] FluMist---[1] 299
64 Inosine [1] Inosine[1] D00054 --[6] 2, 6, 13, 17, 85, 122
65 Inositol [1] Inositol[1] D08079 --[2] 96, 97
66 Inotersen [1] INOTERSEN[1] D10940 [1] TTR 💬[1] Thyroid hormone synthesis 💬[1] 28
67 Insulin detemir [4] Detemir; Insulin detemir; Levemir; Levemir Penfill[1] D04539 [1] INSR 💬[22] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[1] 299
68 Insulin glargine [1] Insulin glargine[1] D03250 [1] INSR 💬[22] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[1] 299
69 Insulin human [1] Human insulin[1] D03230 [1] INSR 💬[22] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[2] 96, 156
70 Insulin-like growth factor II [0] ---[1] 19
71 Interferon alfa [1] Interferon alfa[1] D03305 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[6] 13, 25, 26, 28, 56, 96
72 Interferon alfa-2a [3] Interferon Alfa-2A; Interferon alpha-2a; Roferon-A[1] D00745 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[1] 56
73 Interferon alfa-2b [2] Interferon alfa-2b; Interferon alpha-2B[1] D02745 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[2] 25, 34
74 Interferon beta-1a [6] AVONEX; Interferon Beta 1-A; Interferon Beta 1a; INTERFERON BETA-1A; Interferon-beta-1a; REBIF[1] D04554 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[4] 13, 26, 96, 97
75 Interferon beta-1b [7] BETAFERON; Betaseron; EXTAVIA; Interferon beta 1B; INTERFERON BETA-1B; Interferon-beta-1b; RECOMBINANT INTERFERON BETA-1B[1] D00746 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[1] 13
76 Interferon Gamma [1] Interferon Gamma---[8] 18, 65, 85, 107, 228, 299, 301, 326
77 Interferon gamma-1b [2] ACTIMMUNE; Interferon gamma-1b[1] D00747 [2] IFNGR1,
IFNGR2 💬		[18] Chagas disease, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis 💬[7] 18, 65, 85, 228, 299, 301, 326
78 Interleukin-1 alpha, human recombinant [1] None---[18] 6, 46, 51, 65, 66, 84, 85, 96, 97, 140, 161, 171, 222, 231, 246, 271, 299, 337
79 Interleukin-10 [0] ---[1] 46
80 Interleukin-7 [2] Interleukin-7; Recombinant human interleukin-7---[1] 25
81 Inulin [1] Inulin[1] D00171 --[4] 6, 96, 156, 299
82 Iodide [1] Iodide---[1] 34
83 Iodide I-123 [2] I 123; I-123---[2] 2, 6
84 Iodine [2] Iodine; Iodo[1] D00108 --[2] 28, 46
85 Ioflupane I-123 [3] DaTSCAN; Ioflupane; Ioflupane I 123---[3] 2, 5, 6
86 Iohexol [2] Iohexol; OMNIPAQUE[1] D01817 --[3] 19, 67, 222
87 Iopamidol [0] [1] D01797 --[1] 279
88 Ipilimumab [1] Ipilimumab[1] D04603 [1] CTLA4 💬[4] Autoimmune thyroid disease, Cell adhesion molecules, Rheumatoid arthritis, T cell receptor signaling pathway 💬[1] 159
89 IPL-344 [0] ---[1] 2
90 Ipratropium [1] Ipratropium---[2] 6, 86
91 Iproniazid [1] IPRONIAZID[1] D02579 [2] MAOA,
MAOB 💬		[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
92 Iptacopan [1] Iptacopan[1] D12251 [1] CFB 💬[3] Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬[5] 61, 62, 66, 109, 222
93 IR208 [0] ---[1] 13
94 Irbesartan [2] Aprovel; IRBESARTAN[1] D00523 [1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[4] 66, 167, 168, 222
95 Iron [1] Iron---[6] 18, 96, 97, 238, 254, 284
96 Iron (III) oxide adipate [1] Adipate---[2] 97, 228
97 Iron Dextran [1] Iron Dextran[1] D02141 --[4] 62, 86, 96, 97
98 Iron polymaltose [1] Fusion---[9] 11, 13, 46, 49, 69, 70, 86, 271, 299
99 Iron sucrose [1] Iron sucrose[1] D04616 --[3] 62, 96, 97
100 Isatuximab [1] Isatuximab[1] D11050 [1] CD38 💬[7] Calcium signaling pathway, Hematopoietic cell lineage, Metabolic pathways, Nicotinate and nicotinamide metabolism, Oxytocin signaling pathway, Pancreatic secretion, Salivary secretion 💬[3] 28, 61, 283
101 Iscalimab [1] ISCALIMAB[1] D11610 [1] CD40 💬[17] Allograft rejection, Asthma, Autoimmune thyroid disease, Cell adhesion molecules, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Human T-cell leukemia virus 1 infection, Intestinal immune network for IgA production, Lipid and atherosclerosis, Malaria, NF-kappa B signaling pathway, Primary immunodeficiency, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Viral myocarditis 💬[2] 49, 53
102 ISIS 104838 [1] ISIS 104838---[1] 46
103 Isoflurane [1] Isoflurane[1] D00545 --[1] 6
104 Isoniazid [1] Isoniazid[1] D00346 --[2] 65, 254
105 Isosorbide [1] Isosorbide[1] D00347 --[1] 113
106 Isosorbide dinitrate [2] Isosorbide; ISOSORBIDE DINITRATE[1] D00516 --[1] 113
107 Isotretinoin [1] Isotretinoin[1] D00348 [2] RARA,
RARB 💬		[8] Acute myeloid leukemia, Estrogen signaling pathway, Gastric cancer, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[4] 36, 39, 159, 160
108 Isoxaflutole [1] Balance---[5] 6, 11, 46, 81, 149
109 Isoxsuprine [2] Isoxsuprine; Isoxsuprine Hydrochloride[1] D08092 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 13
110 Isradipine [1] Isradipine[1] D00349 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
111 Istradefylline [1] ISTRADEFYLLINE[1] D04641 [1] ADORA2A 💬[7] Alcoholism, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway 💬[1] 6
112 Itacitinib [1] ITACITINIB[1] D10944 [1] JAK1 💬[27] Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[4] 46, 51, 97, 228
113 ITI-214 [1] ITI-214---[1] 6
114 Itolizumab [1] Itolizumab[1] D12426 [1] CD6 💬[1] Cell adhesion molecules 💬[1] 49
115 Itraconazole [2] ITRACONAZOLE; SPORANOX[1] D00350 --[6] 3, 46, 65, 96, 227, 299
116 Ivacaftor [7] IVACAFTOR; Kaftrio; Kalydeco; Orkambi; Symdeko; Symkevi; Trikafta[1] D09916 [1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
117 Ixazomib [2] Ixazomib; Ninlaro[1] D10130 [1] PSMB5 💬[8] Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬[5] 13, 16, 28, 51, 61
118 Ixekizumab [2] Ixekizumab; TALTZ[1] D10071 [1] IL17A 💬[6] Alcoholic liver disease, Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation 💬[8] 36, 37, 46, 107, 160, 162, 269, 271