Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Tuberculosis 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
2 Tuberculosis 💬
 [1] C3 💬 D11613 💬 Pegcetacoplan [4]  2 , 61, 62, 222 💬
3 Tuberculosis 💬
 [1] CASP9 💬 D11195 💬 Rimiducid [6] 19, 60, 65, 284, 285, 326 💬
4 Tuberculosis 💬
 [1] CD74 💬 D08944 💬 Milatuzumab [1] 49 💬
5 Tuberculosis 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab [1] 49 💬
6 Tuberculosis 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab [1] 49 💬
7 Tuberculosis 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [3] 49, 65, 107 💬
8 Tuberculosis 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
9 Tuberculosis 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
10 Tuberculosis 💬
 [5] IL10, IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
11 Tuberculosis 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
12 Tuberculosis 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
13 Tuberculosis 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
14 Tuberculosis 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
15 Tuberculosis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
16 Tuberculosis 💬
 [1] IL23A 💬 D10912 💬 Brazikumab [2] 96, 97 💬
17 Tuberculosis 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [5] 37, 41, 51, 96, 97 💬
18 Tuberculosis 💬
 [1] IL23A 💬 D11123 💬 Mirikizumab [3] 37, 96, 97 💬
19 Tuberculosis 💬
 [1] IL23A 💬 D11052 💬 Risankizumab [4] 37, 96, 97, 271 💬
20 Tuberculosis 💬
 [1] IL23A 💬 D10400 💬 Tildrakizumab [2] 162, 271 💬
21 Tuberculosis 💬
 [1] IL6 💬 D12487 💬 Olokizumab [2] 46, 96 💬
22 Tuberculosis 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
23 Tuberculosis 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
24 Tuberculosis 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
25 Tuberculosis 💬
 [1] JAK1 💬 D11400 💬 Abrocitinib [1] 84 💬
26 Tuberculosis 💬
 [1] JAK1 💬 D10871 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
27 Tuberculosis 💬
 [1] JAK1 💬 D10944 💬 Itacitinib [4] 46, 51, 97, 228 💬
28 Tuberculosis 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
29 Tuberculosis 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
30 Tuberculosis 💬
 [2] JAK1, JAK2 💬 D10653 💬 Peficitinib [1] 46 💬
31 Tuberculosis 💬
 [2] JAK1, JAK2 💬 D09959 💬 Ruxolitinib [3] 60, 65, 228 💬
32 Tuberculosis 💬
 [2] JAK1, JAK2 💬 D09970 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
33 Tuberculosis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
34 Tuberculosis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
35 Tuberculosis 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
36 Tuberculosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
37 Tuberculosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
38 Tuberculosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
39 Tuberculosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
40 Tuberculosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [2] 49, 222 💬
41 Tuberculosis 💬
 [1] RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
42 Tuberculosis 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
43 Tuberculosis 💬
 [1] SRC 💬 D03252 💬 Bosutinib [2]  2 , 67 💬
44 Tuberculosis 💬
 [1] SRC 💬 D03658 💬 Dasatinib [2] 51, 85 💬
45 Tuberculosis 💬
 [1] SRC 💬 D06414 💬 Dasatinib [2] 51, 85 💬
46 Tuberculosis 💬
 [1] SRC 💬 D09664 💬 Saracatinib [3]  6 , 89, 272 💬
47 Tuberculosis 💬
 [1] SYK 💬 D09347 💬 Fostamatinib [4] 46, 49, 61, 66 💬
48 Tuberculosis 💬
 [3] TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab [3] 51, 85, 222 💬
49 Tuberculosis 💬
 [1] TLR9 💬 D12275 💬 Cobitolimod [1] 97 💬
50 Tuberculosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
51 Tuberculosis 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
52 Tuberculosis 💬
 [1] TNF 💬 D00742 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
53 Tuberculosis 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
54 Tuberculosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
55 Tuberculosis 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
56 Tuberculosis 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
57 Tuberculosis 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
58 Tuberculosis 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
59 Tuberculosis 💬
 [1] VDR 💬 D01518 💬 Alfacalcidol [8] 41, 46, 49, 50, 96, 107, 235, 238 💬
60 Tuberculosis 💬
 [1] VDR 💬 D00122 💬 Calcifediol [2] 113, 299 💬
61 Tuberculosis 💬
 [1] VDR 💬 D01125 💬 Calcipotriol [2] 36, 51 💬
62 Tuberculosis 💬
 [1] VDR 💬 D00129 💬 Calcitriol [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
63 Tuberculosis 💬
 [1] VDR 💬 D00188 💬 Cholecalciferol [24]  6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬
64 Tuberculosis 💬
 [1] VDR 💬 D00299 💬 Dihydrotachysterol [2]  6 , 85 💬
65 Tuberculosis 💬
 [1] VDR 💬 D07578 💬 Eldecalcitol [1] 46 💬
66 Tuberculosis 💬
 [1] VDR 💬 D00187 💬 Ergocalciferol [6] 46, 49, 84, 96, 97, 299 💬
67 Tuberculosis 💬
 [1] VDR 💬 D00930 💬 Paricalcitol [5] 19, 66, 218, 238, 298 💬