Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adherens junction 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
4 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D07552 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
5 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00358 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
6 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D08127 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
7 African trypanosomiasis 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
8 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
9 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
10 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
11 Aldosterone synthesis and secretion 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
12 Aldosterone-regulated sodium reabsorption 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
13 Amoebiasis 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
14 Amphetamine addiction 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
15 AMPK signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
16 Apelin signaling pathway 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
17 Autophagy - animal 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
18 B cell receptor signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
19 Breast cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
20 Calcium signaling pathway 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
21 Calcium signaling pathway 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
22 Calcium signaling pathway 💬
 [1] OXTR 💬 D00089 💬 Oxytocin [7]  6 , 72, 127, 168, 193, 206, 226 💬
23 Calcium signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
24 cAMP signaling pathway 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
25 cAMP signaling pathway 💬
 [1] OXTR 💬 D00089 💬 Oxytocin [7]  6 , 72, 127, 168, 193, 206, 226 💬
26 Carbohydrate digestion and absorption 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
27 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
28 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
29 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
30 Chemical carcinogenesis - receptor activation 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
31 Chemokine signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
32 Choline metabolism in cancer 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
33 Cholinergic synapse 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
34 Circadian entrainment 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
35 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
36 Coronavirus disease - COVID-19 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
37 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
38 Cushing syndrome 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
39 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
40 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
41 Diabetic cardiomyopathy 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
42 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
43 Dopaminergic synapse 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
44 Dopaminergic synapse 💬
 [1] SCN1A 💬 D07552 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
45 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00358 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
46 Dopaminergic synapse 💬
 [1] SCN1A 💬 D08127 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
47 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
48 EGFR tyrosine kinase inhibitor resistance 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
49 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
50 Endocrine resistance 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
51 Endocytosis 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
52 ErbB signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
53 Fc gamma R-mediated phagocytosis 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
54 Focal adhesion 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
55 Focal adhesion 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
56 FoxO signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
57 GABAergic synapse 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
58 Gap junction 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
59 Gap junction 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
60 Gastric acid secretion 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
61 Glioma 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
62 Glioma 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
63 Glutamatergic synapse 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
64 GnRH secretion 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
65 GnRH signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
66 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
67 Growth hormone synthesis, secretion and action 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
68 Hepatitis B 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
69 Hepatocellular carcinoma 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
70 Hepatocellular carcinoma 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
71 HIF-1 signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
72 HIF-1 signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
73 Human cytomegalovirus infection 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
74 Human immunodeficiency virus 1 infection 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
75 Inflammatory mediator regulation of TRP channels 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
76 Influenza A 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
77 Insulin resistance 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
78 Insulin secretion 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
79 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
80 Leishmaniasis 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
81 Leukocyte transendothelial migration 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
82 Long-term depression 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
83 Long-term depression 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
84 Long-term potentiation 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
85 Longevity regulating pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
86 Longevity regulating pathway - multiple species 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
87 MAPK signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
88 MAPK signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
89 Melanogenesis 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
90 Melanoma 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
91 MicroRNAs in cancer 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
92 Morphine addiction 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
93 mTOR signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
94 mTOR signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
95 Natural killer cell mediated cytotoxicity 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
96 Neuroactive ligand-receptor interaction 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
97 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
98 Neuroactive ligand-receptor interaction 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
99 Neuroactive ligand-receptor interaction 💬
 [1] OXTR 💬 D00089 💬 Oxytocin [7]  6 , 72, 127, 168, 193, 206, 226 💬
100 Neutrophil extracellular trap formation 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
101 NF-kappa B signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
102 Non-small cell lung cancer 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
103 Oocyte meiosis 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
104 Ovarian steroidogenesis 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
105 Oxytocin signaling pathway 💬
 [1] OXTR 💬 D00089 💬 Oxytocin [7]  6 , 72, 127, 168, 193, 206, 226 💬
106 Oxytocin signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
107 Pancreatic secretion 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
108 Parathyroid hormone synthesis, secretion and action 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
109 Pathways in cancer 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
110 Pathways in cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
111 Pathways in cancer 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
112 Pathways of neurodegeneration - multiple diseases 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
113 Phosphatidylinositol signaling system 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
114 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
115 PI3K-Akt signaling pathway 💬
 [2] GHR, IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
116 Progesterone-mediated oocyte maturation 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
117 Prostate cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
118 Proteoglycans in cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
119 Proteoglycans in cancer 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
120 Rap1 signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
121 Rap1 signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
122 Ras signaling pathway 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
123 Ras signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
124 Regulation of lipolysis in adipocytes 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
125 Renin secretion 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
126 Renin secretion 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
127 Renin-angiotensin system 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
128 Retrograde endocannabinoid signaling 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
129 Salivary secretion 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
130 Salivary secretion 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
131 Serotonergic synapse 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
132 Signaling pathways regulating pluripotency of stem cells 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
133 Sphingolipid signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
134 Spinocerebellar ataxia 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
135 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 D07552 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
136 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 D00358 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
137 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 D08127 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
138 Thyroid hormone signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
139 Thyroid hormone synthesis 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
140 Transcriptional misregulation in cancer 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
141 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
142 Vascular smooth muscle contraction 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
143 VEGF signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
144 Wnt signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬

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