Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adipocytokine signaling pathway 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
2 Alcoholic liver disease 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
3 AMPK signaling pathway 💬
 [1] HMGCR 💬 D07474 💬 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
4 AMPK signaling pathway 💬
 [1] HMGCR 💬 D07983 💬 Fluvastatin [3] 79, 218, 222 💬
5 AMPK signaling pathway 💬
 [1] HMGCR 💬 D00359 💬 Lovastatin [11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
6 AMPK signaling pathway 💬
 [1] HMGCR 💬 D08410 💬 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
7 AMPK signaling pathway 💬
 [1] HMGCR 💬 D08492 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
8 AMPK signaling pathway 💬
 [1] HMGCR 💬 D00434 💬 Simvastatin [21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
9 Bile secretion 💬
 [1] HMGCR 💬 D07474 💬 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
10 Bile secretion 💬
 [1] HMGCR 💬 D07983 💬 Fluvastatin [3] 79, 218, 222 💬
11 Bile secretion 💬
 [1] HMGCR 💬 D00359 💬 Lovastatin [11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
12 Bile secretion 💬
 [1] HMGCR 💬 D08410 💬 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
13 Bile secretion 💬
 [1] HMGCR 💬 D08492 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
14 Bile secretion 💬
 [1] HMGCR 💬 D00434 💬 Simvastatin [21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
15 cAMP signaling pathway 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
16 Chemical carcinogenesis - receptor activation 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
17 Cholesterol metabolism 💬
 [1] ANGPTL3 💬 D11753 💬 Evinacumab [1] 79 💬
18 Cholesterol metabolism 💬
 [1] CETP 💬 D08855 💬 Anacetrapib [1] 79 💬
19 Cholesterol metabolism 💬
 [1] PCSK9 💬 D10335 💬 Alirocumab [1] 79 💬
20 Cholesterol metabolism 💬
 [1] PCSK9 💬 D10557 💬 Evolocumab [2] 79, 222 💬
21 Cholesterol metabolism 💬
 [1] PCSK9 💬 D11931 💬 Inclisiran [1] 79 💬
22 Diabetic cardiomyopathy 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
23 Fat digestion and absorption 💬
 [1] MTTP 💬 D09637 💬 Lomitapide [1] 79 💬
24 Fat digestion and absorption 💬
 [1] NPC1L1 💬 D01966 💬 Ezetimibe [4] 49, 79, 93, 260 💬
25 Glucagon signaling pathway 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
26 Hepatitis C 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
27 Insulin resistance 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
28 Metabolic pathways 💬
 [1] HMGCR 💬 D07474 💬 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
29 Metabolic pathways 💬
 [1] HMGCR 💬 D07983 💬 Fluvastatin [3] 79, 218, 222 💬
30 Metabolic pathways 💬
 [1] HMGCR 💬 D00359 💬 Lovastatin [11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
31 Metabolic pathways 💬
 [1] HMGCR 💬 D08410 💬 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
32 Metabolic pathways 💬
 [1] HMGCR 💬 D08492 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
33 Metabolic pathways 💬
 [1] HMGCR 💬 D00434 💬 Simvastatin [21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
34 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00473 💬 Prednisone [45]  2 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬
35 Non-alcoholic fatty liver disease 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
36 PPAR signaling pathway 💬
 [1] PPARA 💬 D00565 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
37 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 D07474 💬 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
38 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 D07983 💬 Fluvastatin [3] 79, 218, 222 💬
39 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 D00359 💬 Lovastatin [11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
40 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 D08410 💬 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
41 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 D08492 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
42 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 D00434 💬 Simvastatin [21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬

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