Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Cytokine-cytokine receptor interaction 💬
 [1] ACVR2A 💬 D09670 💬 Sotatercept [2] 86, 284 💬
2 Cytokine-cytokine receptor interaction 💬
 [2] ACVR2A, ACVR2B 💬 D10620 💬 Bimagrumab [1] 15 💬
3 Cytokine-cytokine receptor interaction 💬
 [1] ACVR2B 💬 D11701 💬 Luspatercept [1] 60 💬
4 Cytokine-cytokine receptor interaction 💬
 [6] CCL2, IL10, IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
5 Cytokine-cytokine receptor interaction 💬
 [2] CCR2, CCR5 💬 D09878 💬 Cenicriviroc [1] 94 💬
6 Cytokine-cytokine receptor interaction 💬
 [1] CCR4 💬 D09761 💬 Mogamulizumab [1] 26 💬
7 Cytokine-cytokine receptor interaction 💬
 [1] CCR5 💬 D06670 💬 Maraviroc [2] 46, 84 💬
8 Cytokine-cytokine receptor interaction 💬
 [1] CD4 💬 D06356 💬 Zanolimumab [1] 46 💬
9 Cytokine-cytokine receptor interaction 💬
 [1] CD40 💬 D11357 💬 Bleselumab [1] 222 💬
10 Cytokine-cytokine receptor interaction 💬
 [1] CD40 💬 D11610 💬 Iscalimab [2] 49, 53 💬
11 Cytokine-cytokine receptor interaction 💬
 [1] CD40 💬 D11597 💬 Ravagalimab [2] 53, 97 💬
12 Cytokine-cytokine receptor interaction 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
13 Cytokine-cytokine receptor interaction 💬
 [1] CSF1R 💬 D11270 💬 Pexidartinib [1] 34 💬
14 Cytokine-cytokine receptor interaction 💬
 [1] CSF1R 💬 D08552 💬 Sunitinib [2] 28, 34 💬
15 Cytokine-cytokine receptor interaction 💬
 [1] CSF2 💬 D11343 💬 Otilimab [1] 46 💬
16 Cytokine-cytokine receptor interaction 💬
 [1] CSF2RA 💬 D09930 💬 Mavrilimumab [2] 41, 46 💬
17 Cytokine-cytokine receptor interaction 💬
 [1] CSF2RA 💬 D05066 💬 Molgramostim [3] 97, 229, 299 💬
18 Cytokine-cytokine receptor interaction 💬
 [1] CSF2RA 💬 D05712 💬 Regramostim [1] 229 💬
19 Cytokine-cytokine receptor interaction 💬
 [1] CSF2RA 💬 D05803 💬 Sargramostim [7]  6 , 28, 60, 62, 96, 229, 285 💬
20 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
21 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
22 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 D06889 💬 Pegfilgrastim [1] 60 💬
23 Cytokine-cytokine receptor interaction 💬
 [2] CXCR1, CXCR2 💬 D08984 💬 Reparixin [2] 298, 299 💬
24 Cytokine-cytokine receptor interaction 💬
 [1] CXCR4 💬 D08971 💬 Plerixafor [5] 19, 20, 65, 285, 299 💬
25 Cytokine-cytokine receptor interaction 💬
 [1] EPOR 💬 D09946 💬 Peginesatide [1] 283 💬
26 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 D11486 💬 Lonapegsomatropin [1] 78 💬
27 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
28 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 D05394 💬 Pegvisomant [2] 78, 265 💬
29 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 D11194 💬 Somapacitan [2] 78, 195 💬
30 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 D11193 💬 Somavaratan [1] 78 💬
31 Cytokine-cytokine receptor interaction 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab [1] 49 💬
32 Cytokine-cytokine receptor interaction 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab [1] 49 💬
33 Cytokine-cytokine receptor interaction 💬
 [2] IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab [3] 46, 49, 53 💬
34 Cytokine-cytokine receptor interaction 💬
 [2] IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬
35 Cytokine-cytokine receptor interaction 💬
 [2] IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a [1] 56 💬
36 Cytokine-cytokine receptor interaction 💬
 [2] IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b [2] 25, 34 💬
37 Cytokine-cytokine receptor interaction 💬
 [2] IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬
38 Cytokine-cytokine receptor interaction 💬
 [2] IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b [1] 13 💬
39 Cytokine-cytokine receptor interaction 💬
 [2] IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a [1] 13 💬
40 Cytokine-cytokine receptor interaction 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [3] 49, 65, 107 💬
41 Cytokine-cytokine receptor interaction 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
42 Cytokine-cytokine receptor interaction 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
43 Cytokine-cytokine receptor interaction 💬
 [1] IL11RA 💬 D05266 💬 Oprelvekin [2] 96, 288 💬
44 Cytokine-cytokine receptor interaction 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
45 Cytokine-cytokine receptor interaction 💬
 [1] IL13 💬 D08857 💬 Anrukinzumab [1] 97 💬
46 Cytokine-cytokine receptor interaction 💬
 [1] IL13 💬 D09633 💬 Lebrikizumab [1] 85 💬
47 Cytokine-cytokine receptor interaction 💬
 [1] IL13 💬 D09979 💬 Tralokinumab [2] 85, 97 💬
48 Cytokine-cytokine receptor interaction 💬
 [1] IL17A 💬 D10071 💬 Ixekizumab [8] 36, 37, 46, 107, 160, 162, 269, 271 💬
49 Cytokine-cytokine receptor interaction 💬
 [1] IL17A 💬 D09967 💬 Secukinumab [8] 13, 37, 41, 46, 107, 160, 269, 271 💬
50 Cytokine-cytokine receptor interaction 💬
 [2] IL17A, IL17F 💬 D11550 💬 Bimekizumab [3] 46, 97, 271 💬
51 Cytokine-cytokine receptor interaction 💬
 [2] IL17A, TNFSF13B 💬 D11127 💬 Tibulizumab [1] 53 💬
52 Cytokine-cytokine receptor interaction 💬
 [1] IL17RA 💬 D10061 💬 Brodalumab [2] 37, 51 💬
53 Cytokine-cytokine receptor interaction 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
54 Cytokine-cytokine receptor interaction 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
55 Cytokine-cytokine receptor interaction 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
56 Cytokine-cytokine receptor interaction 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
57 Cytokine-cytokine receptor interaction 💬
 [2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
58 Cytokine-cytokine receptor interaction 💬
 [1] IL1RL2 💬 D11892 💬 Imsidolimab [1] 37 💬
59 Cytokine-cytokine receptor interaction 💬
 [1] IL1RL2 💬 D12066 💬 Spesolimab [3] 37, 96, 97 💬
60 Cytokine-cytokine receptor interaction 💬
 [1] IL20 💬 D11756 💬 Fletikumab [1] 46 💬
61 Cytokine-cytokine receptor interaction 💬
 [1] IL22 💬 D11953 💬 Efmarodocokin alfa [2] 96, 97 💬
62 Cytokine-cytokine receptor interaction 💬
 [1] IL23A 💬 D10912 💬 Brazikumab [2] 96, 97 💬
63 Cytokine-cytokine receptor interaction 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [5] 37, 41, 51, 96, 97 💬
64 Cytokine-cytokine receptor interaction 💬
 [1] IL23A 💬 D11123 💬 Mirikizumab [3] 37, 96, 97 💬
65 Cytokine-cytokine receptor interaction 💬
 [1] IL23A 💬 D11052 💬 Risankizumab [4] 37, 96, 97, 271 💬
66 Cytokine-cytokine receptor interaction 💬
 [1] IL23A 💬 D10400 💬 Tildrakizumab [2] 162, 271 💬
67 Cytokine-cytokine receptor interaction 💬
 [1] IL2RA 💬 D03058 💬 Basiliximab [6]  2 , 50, 66, 97, 222, 228 💬
68 Cytokine-cytokine receptor interaction 💬
 [1] IL2RA 💬 D03639 💬 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284 💬
69 Cytokine-cytokine receptor interaction 💬
 [3] IL2RA, IL2RB, IL2RG 💬 D00748 💬 Aldesleukin [6]  2 , 35, 49, 65, 96, 97 💬
70 Cytokine-cytokine receptor interaction 💬
 [1] IL31RA 💬 D11080 💬 Nemolizumab [1] 51 💬
71 Cytokine-cytokine receptor interaction 💬
 [1] IL4 💬 D03117 💬 Binetrakin [1] 46 💬
72 Cytokine-cytokine receptor interaction 💬
 [1] IL4R 💬 D10354 💬 Dupilumab [5] 51, 97, 98, 160, 162 💬
73 Cytokine-cytokine receptor interaction 💬
 [1] IL5 💬 D04923 💬 Mepolizumab [4] 44, 45, 98, 162 💬
74 Cytokine-cytokine receptor interaction 💬
 [1] IL5 💬 D08985 💬 Reslizumab [2] 44, 98 💬
75 Cytokine-cytokine receptor interaction 💬
 [1] IL5RA 💬 D09874 💬 Benralizumab [5] 44, 45, 98, 162, 299 💬
76 Cytokine-cytokine receptor interaction 💬
 [1] IL6 💬 D12487 💬 Olokizumab [2] 46, 96 💬
77 Cytokine-cytokine receptor interaction 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
78 Cytokine-cytokine receptor interaction 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
79 Cytokine-cytokine receptor interaction 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
80 Cytokine-cytokine receptor interaction 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
81 Cytokine-cytokine receptor interaction 💬
 [1] IL6R 💬 D11079 💬 Satralizumab [3] 11, 13, 86 💬
82 Cytokine-cytokine receptor interaction 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [21]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
83 Cytokine-cytokine receptor interaction 💬
 [1] LEPR 💬 D05014 💬 Metreleptin [1] 265 💬
84 Cytokine-cytokine receptor interaction 💬
 [1] LTA 💬 D10187 💬 Pateclizumab [1] 46 💬
85 Cytokine-cytokine receptor interaction 💬
 [2] LTA, TNF 💬 D00742 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
86 Cytokine-cytokine receptor interaction 💬
 [1] LTB 💬 D08866 💬 Baminercept [4] 13, 46, 53, 97 💬
87 Cytokine-cytokine receptor interaction 💬
 [1] MPL 💬 D10306 💬 Avatrombopag [2] 60, 63 💬
88 Cytokine-cytokine receptor interaction 💬
 [1] MPL 💬 D08990 💬 Romiplostim [4] 60, 63, 64, 65 💬
89 Cytokine-cytokine receptor interaction 💬
 [1] MSTN 💬 D11797 💬 Apitegromab [1]  3  💬
90 Cytokine-cytokine receptor interaction 💬
 [1] MSTN 💬 D11047 💬 Domagrozumab [1] 113 💬
91 Cytokine-cytokine receptor interaction 💬
 [1] MSTN 💬 D05917 💬 Stamulumab [1] 113 💬
92 Cytokine-cytokine receptor interaction 💬
 [1] MSTN 💬 D11265 💬 Talditercept alfa [1]  3  💬
93 Cytokine-cytokine receptor interaction 💬
 [1] NGF 💬 D09387 💬 Tanezumab [2] 226, 298 💬
94 Cytokine-cytokine receptor interaction 💬
 [1] NGFR 💬 D11028 💬 Cenegermin [2] 53, 90 💬
95 Cytokine-cytokine receptor interaction 💬
 [1] PRL 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
96 Cytokine-cytokine receptor interaction 💬
 [1] PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
97 Cytokine-cytokine receptor interaction 💬
 [1] PRL 💬 D01348 💬 Terguride [2] 51, 86 💬
98 Cytokine-cytokine receptor interaction 💬
 [3] TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab [3] 51, 85, 222 💬
99 Cytokine-cytokine receptor interaction 💬
 [1] TNF 💬 D02597 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
100 Cytokine-cytokine receptor interaction 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
101 Cytokine-cytokine receptor interaction 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
102 Cytokine-cytokine receptor interaction 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
103 Cytokine-cytokine receptor interaction 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
104 Cytokine-cytokine receptor interaction 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
105 Cytokine-cytokine receptor interaction 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
106 Cytokine-cytokine receptor interaction 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
107 Cytokine-cytokine receptor interaction 💬
 [1] TNFRSF13C 💬 D12151 💬 Ianalumab [7] 35, 46, 49, 53, 61, 63, 95 💬
108 Cytokine-cytokine receptor interaction 💬
 [1] TNFRSF17 💬 D11595 💬 Belantamab mafodotin [1] 28 💬
109 Cytokine-cytokine receptor interaction 💬
 [1] TNFRSF8 💬 D09587 💬 Brentuximab vedotin [2] 49, 51 💬
110 Cytokine-cytokine receptor interaction 💬
 [1] TNFSF11 💬 D03684 💬 Denosumab [8] 46, 50, 70, 93, 95, 96, 274, 299 💬
111 Cytokine-cytokine receptor interaction 💬
 [2] TNFSF13, TNFSF13B 💬 D09704 💬 Atacicept [4] 13, 46, 49, 66 💬
112 Cytokine-cytokine receptor interaction 💬
 [1] TNFSF13B 💬 D03068 💬 Belimumab [13] 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
113 Cytokine-cytokine receptor interaction 💬
 [1] TNFSF13B 💬 D10083 💬 Tabalumab [2] 46, 49 💬
114 Cytokine-cytokine receptor interaction 💬
 [1] TSLP 💬 D11771 💬 Tezepelumab [1] 98 💬