Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
2 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D01173 💬 Cilnidipine [1] 67 💬
3 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
4 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D00349 💬 Isradipine [1]  6  💬
5 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D08270 💬 Nicardipine [2] 70, 86 💬
6 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D00437 💬 Nifedipine [2] 50, 81 💬
7 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D01908 💬 Nilvadipine [1] 90 💬
8 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D08340 💬 Perhexiline [2] 58, 272 💬
9 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D08441 💬 Propiverine [1] 226 💬
10 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D02356 💬 Verapamil [4] 58, 96, 140, 167 💬
11 Glutamatergic synapse 💬
 [11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
12 Glutamatergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
13 Glutamatergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D02696 💬 Talampanel [2]  2 ,  6  💬
14 Glutamatergic synapse 💬
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
15 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07058 💬 Acamprosate [2]  6 , 206 💬
16 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07441 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
17 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D03742 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
18 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
19 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
20 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D09917 💬 Latrepirdine [1]  8  💬
21 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
22 Glutamatergic synapse 💬
 [1] KCNJ3 💬 D02910 💬 Amiodarone [2] 28, 127 💬
23 Glutamatergic synapse 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
24 Glutamatergic synapse 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
25 Glutamatergic synapse 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
26 Glutamatergic synapse 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
27 Glutamatergic synapse 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [2] 49, 222 💬
28 Glutamatergic synapse 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬