Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D00227 💬 Aminophylline [1] 63 💬
2 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D00528 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
3 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D01453 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
4 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D00371 💬 Theophylline [2] 236, 299 💬
5 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D06103 💬 Theophylline [2] 236, 299 💬
6 Sphingolipid signaling pathway 💬
 [2] ADORA1, ADORA3 💬 D00045 💬 Adenosine [3] 13, 58, 65 💬
7 Sphingolipid signaling pathway 💬
 [2] ADORA1, ADORA3 💬 D02769 💬 Adenosine phosphate [1] 46 💬
8 Sphingolipid signaling pathway 💬
 [1] ADORA3 💬 D10971 💬 Piclidenoson [1] 46 💬
9 Sphingolipid signaling pathway 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
10 Sphingolipid signaling pathway 💬
 [1] FCER1A 💬 D05251 💬 Omalizumab [7] 46, 53, 65, 98, 162, 226, 299 💬
11 Sphingolipid signaling pathway 💬
 [1] FYN 💬 D03658 💬 Dasatinib [2] 51, 85 💬
12 Sphingolipid signaling pathway 💬
 [1] FYN 💬 D06414 💬 Dasatinib [2] 51, 85 💬
13 Sphingolipid signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
14 Sphingolipid signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
15 Sphingolipid signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D11675 💬 Mirdametinib [1] 34 💬
16 Sphingolipid signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
17 Sphingolipid signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
18 Sphingolipid signaling pathway 💬
 [1] MAP3K5 💬 D10988 💬 Selonsertib [1] 86 💬
19 Sphingolipid signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
20 Sphingolipid signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
21 Sphingolipid signaling pathway 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
22 Sphingolipid signaling pathway 💬
 [1] OPRD1 💬 D08144 💬 Loperamide [2] 13, 97 💬
23 Sphingolipid signaling pathway 💬
 [1] OPRD1 💬 D08246 💬 Nalbuphine [1] 85 💬
24 Sphingolipid signaling pathway 💬
 [1] OPRD1 💬 D05111 💬 Nalmefene [1]  6  💬
25 Sphingolipid signaling pathway 💬
 [1] OPRD1 💬 D08249 💬 Naloxone [2]  6 , 226 💬
26 Sphingolipid signaling pathway 💬
 [1] OPRD1 💬 D05113 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
27 Sphingolipid signaling pathway 💬
 [1] OPRD1 💬 D05312 💬 Oxycodone [5]  6 , 13, 70, 226, 298 💬
28 Sphingolipid signaling pathway 💬
 [1] PIK3CA 💬 D11011 💬 Alpelisib [1] 138 💬
29 Sphingolipid signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
30 Sphingolipid signaling pathway 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
31 Sphingolipid signaling pathway 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
32 Sphingolipid signaling pathway 💬
 [1] PRKCE 💬 D09671 💬 Sotrastaurin [1] 97 💬
33 Sphingolipid signaling pathway 💬
 [1] RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
34 Sphingolipid signaling pathway 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
35 Sphingolipid signaling pathway 💬
 [2] ROCK1, ROCK2 💬 D07941 💬 Fasudil [4]  2 ,  5 ,  7 , 51 💬
36 Sphingolipid signaling pathway 💬
 [1] ROCK2 💬 D11815 💬 Belumosudil [2] 51, 85 💬
37 Sphingolipid signaling pathway 💬
 [1] S1PR1 💬 D11283 💬 Cenerimod [1] 49 💬
38 Sphingolipid signaling pathway 💬
 [1] S1PR1 💬 D10001 💬 Fingolimod [3] 13, 14, 156 💬
39 Sphingolipid signaling pathway 💬
 [1] S1PR1 💬 D11215 💬 Ponesimod [1] 13 💬
40 Sphingolipid signaling pathway 💬
 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5 💬 D10905 💬 Amiselimod [1] 97 💬
41 Sphingolipid signaling pathway 💬
 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5 💬 D10930 💬 Etrasimod [3] 96, 97, 98 💬
42 Sphingolipid signaling pathway 💬
 [5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5 💬 D10968 💬 Ozanimod [3] 13, 96, 97 💬
43 Sphingolipid signaling pathway 💬
 [2] S1PR1, S1PR5 💬 D11460 💬 Siponimod [2] 13, 50 💬
44 Sphingolipid signaling pathway 💬
 [1] SMPD1 💬 D10820 💬 Olipudase alfa [1] 19 💬
45 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
46 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
47 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D00742 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
48 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
49 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
50 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
51 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
52 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
53 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
54 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
55 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬