Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 T cell receptor signaling pathway 💬
 [3] CD3D, CD3E, CD3G 💬 D08959 💬 Otelixizumab [1] 46 💬
2 T cell receptor signaling pathway 💬
 [3] CD3D, CD3E, CD3G 💬 D06314 💬 Visilizumab [2] 96, 97 💬
3 T cell receptor signaling pathway 💬
 [1] CD3E 💬 D11463 💬 Mosunetuzumab [1] 49 💬
4 T cell receptor signaling pathway 💬
 [1] CD4 💬 D06356 💬 Zanolimumab [1] 46 💬
5 T cell receptor signaling pathway 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
6 T cell receptor signaling pathway 💬
 [1] CDK4 💬 D10688 💬 Abemaciclib [1] 34 💬
7 T cell receptor signaling pathway 💬
 [1] CSF2 💬 D11343 💬 Otilimab [1] 46 💬
8 T cell receptor signaling pathway 💬
 [1] CTLA4 💬 D04603 💬 Ipilimumab [1] 159 💬
9 T cell receptor signaling pathway 💬
 [1] CTLA4 💬 D06657 💬 Tremelimumab [1] 96 💬
10 T cell receptor signaling pathway 💬
 [2] FYN, LCK 💬 D03658 💬 Dasatinib [2] 51, 85 💬
11 T cell receptor signaling pathway 💬
 [2] FYN, LCK 💬 D06414 💬 Dasatinib [2] 51, 85 💬
12 T cell receptor signaling pathway 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [3] 49, 65, 107 💬
13 T cell receptor signaling pathway 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
14 T cell receptor signaling pathway 💬
 [2] IL10, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
15 T cell receptor signaling pathway 💬
 [1] IL4 💬 D03117 💬 Binetrakin [1] 46 💬
16 T cell receptor signaling pathway 💬
 [1] IL5 💬 D04923 💬 Mepolizumab [4] 44, 45, 98, 162 💬
17 T cell receptor signaling pathway 💬
 [1] IL5 💬 D08985 💬 Reslizumab [2] 44, 98 💬
18 T cell receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
19 T cell receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
20 T cell receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D11675 💬 Mirdametinib [1] 34 💬
21 T cell receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
22 T cell receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
23 T cell receptor signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
24 T cell receptor signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
25 T cell receptor signaling pathway 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
26 T cell receptor signaling pathway 💬
 [1] PDCD1 💬 D10316 💬 Nivolumab [12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
27 T cell receptor signaling pathway 💬
 [1] PDCD1 💬 D10574 💬 Pembrolizumab [2] 25, 285 💬
28 T cell receptor signaling pathway 💬
 [1] PIK3CA 💬 D11011 💬 Alpelisib [1] 138 💬
29 T cell receptor signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
30 T cell receptor signaling pathway 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
31 T cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
32 T cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
33 T cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
34 T cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
35 T cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [2] 49, 222 💬
36 T cell receptor signaling pathway 💬
 [1] PRKCQ 💬 D09671 💬 Sotrastaurin [1] 97 💬
37 T cell receptor signaling pathway 💬
 [1] RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
38 T cell receptor signaling pathway 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
39 T cell receptor signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
40 T cell receptor signaling pathway 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
41 T cell receptor signaling pathway 💬
 [1] TNF 💬 D00742 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
42 T cell receptor signaling pathway 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
43 T cell receptor signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
44 T cell receptor signaling pathway 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
45 T cell receptor signaling pathway 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
46 T cell receptor signaling pathway 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
47 T cell receptor signaling pathway 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
48 T cell receptor signaling pathway 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬