Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Necroptosis 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
2 Necroptosis 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab [1] 49 💬
3 Necroptosis 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab [1] 49 💬
4 Necroptosis 💬
 [2] IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab [3] 46, 49, 53 💬
5 Necroptosis 💬
 [2] IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬
6 Necroptosis 💬
 [2] IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a [1] 56 💬
7 Necroptosis 💬
 [2] IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b [2] 25, 34 💬
8 Necroptosis 💬
 [2] IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬
9 Necroptosis 💬
 [2] IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b [1] 13 💬
10 Necroptosis 💬
 [2] IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a [1] 13 💬
11 Necroptosis 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [3] 49, 65, 107 💬
12 Necroptosis 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
13 Necroptosis 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
14 Necroptosis 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
15 Necroptosis 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
16 Necroptosis 💬
 [3] IL1A, IL1B, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
17 Necroptosis 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
18 Necroptosis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
19 Necroptosis 💬
 [1] JAK1 💬 D11400 💬 Abrocitinib [1] 84 💬
20 Necroptosis 💬
 [1] JAK1 💬 D10871 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
21 Necroptosis 💬
 [1] JAK1 💬 D10944 💬 Itacitinib [4] 46, 51, 97, 228 💬
22 Necroptosis 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
23 Necroptosis 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
24 Necroptosis 💬
 [2] JAK1, JAK2 💬 D09959 💬 Ruxolitinib [3] 60, 65, 228 💬
25 Necroptosis 💬
 [3] JAK1, JAK2, JAK3 💬 D10653 💬 Peficitinib [1] 46 💬
26 Necroptosis 💬
 [4] JAK1, JAK2, JAK3, TYK2 💬 D09970 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
27 Necroptosis 💬
 [1] PARP1 💬 D09730 💬 Olaparib [2] 86, 285 💬
28 Necroptosis 💬
 [1] SMPD1 💬 D10820 💬 Olipudase alfa [1] 19 💬
29 Necroptosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
30 Necroptosis 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
31 Necroptosis 💬
 [1] TNF 💬 D00742 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
32 Necroptosis 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
33 Necroptosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
34 Necroptosis 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
35 Necroptosis 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
36 Necroptosis 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
37 Necroptosis 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
38 Necroptosis 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
39 Necroptosis 💬
 [1] TYK2 💬 D11817 💬 Deucravacitinib [3] 49, 96, 97 💬