Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Hematopoietic cell lineage 💬
 [1] ANPEP 💬 D00087 💬 Ubenimex [1] 86 💬
2 Hematopoietic cell lineage 💬
 [1] CD19 💬 D11757 💬 Inebilizumab [4] 11, 13, 51, 300 💬
3 Hematopoietic cell lineage 💬
 [1] CD19 💬 D11496 💬 Obexelimab [1] 300 💬
4 Hematopoietic cell lineage 💬
 [1] CD22 💬 D04036 💬 Epratuzumab [1] 49 💬
5 Hematopoietic cell lineage 💬
 [1] CD38 💬 D10777 💬 Daratumumab [5] 13, 28, 48, 49, 63 💬
6 Hematopoietic cell lineage 💬
 [1] CD38 💬 D11050 💬 Isatuximab [3] 28, 61, 283 💬
7 Hematopoietic cell lineage 💬
 [1] CD38 💬 D11945 💬 Mezagitamab [2] 63, 66 💬
8 Hematopoietic cell lineage 💬
 [3] CD3D, CD3E, CD3G 💬 D08959 💬 Otelixizumab [1] 46 💬
9 Hematopoietic cell lineage 💬
 [3] CD3D, CD3E, CD3G 💬 D06314 💬 Visilizumab [2] 96, 97 💬
10 Hematopoietic cell lineage 💬
 [2] CD3E, MS4A1 💬 D11463 💬 Mosunetuzumab [1] 49 💬
11 Hematopoietic cell lineage 💬
 [1] CD4 💬 D06356 💬 Zanolimumab [1] 46 💬
12 Hematopoietic cell lineage 💬
 [3] CSF1R, FLT3, KIT 💬 D11270 💬 Pexidartinib [1] 34 💬
13 Hematopoietic cell lineage 💬
 [3] CSF1R, FLT3, KIT 💬 D08552 💬 Sunitinib [2] 28, 34 💬
14 Hematopoietic cell lineage 💬
 [1] CSF2 💬 D11343 💬 Otilimab [1] 46 💬
15 Hematopoietic cell lineage 💬
 [1] CSF2RA 💬 D09930 💬 Mavrilimumab [2] 41, 46 💬
16 Hematopoietic cell lineage 💬
 [1] CSF2RA 💬 D05066 💬 Molgramostim [3] 97, 229, 299 💬
17 Hematopoietic cell lineage 💬
 [1] CSF2RA 💬 D05712 💬 Regramostim [1] 229 💬
18 Hematopoietic cell lineage 💬
 [1] CSF2RA 💬 D05803 💬 Sargramostim [7]  6 , 28, 60, 62, 96, 229, 285 💬
19 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
20 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 D03247 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
21 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 D06889 💬 Pegfilgrastim [1] 60 💬
22 Hematopoietic cell lineage 💬
 [1] EPOR 💬 D09946 💬 Peginesatide [1] 283 💬
23 Hematopoietic cell lineage 💬
 [2] FLT3, KIT 💬 D08524 💬 Sorafenib [2] 34, 86 💬
24 Hematopoietic cell lineage 💬
 [1] IL11RA 💬 D05266 💬 Oprelvekin [2] 96, 288 💬
25 Hematopoietic cell lineage 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
26 Hematopoietic cell lineage 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
27 Hematopoietic cell lineage 💬
 [4] IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
28 Hematopoietic cell lineage 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
29 Hematopoietic cell lineage 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
30 Hematopoietic cell lineage 💬
 [2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
31 Hematopoietic cell lineage 💬
 [1] IL2RA 💬 D00748 💬 Aldesleukin [6]  2 , 35, 49, 65, 96, 97 💬
32 Hematopoietic cell lineage 💬
 [1] IL2RA 💬 D03058 💬 Basiliximab [6]  2 , 50, 66, 97, 222, 228 💬
33 Hematopoietic cell lineage 💬
 [1] IL2RA 💬 D03639 💬 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284 💬
34 Hematopoietic cell lineage 💬
 [1] IL4 💬 D03117 💬 Binetrakin [1] 46 💬
35 Hematopoietic cell lineage 💬
 [1] IL4R 💬 D10354 💬 Dupilumab [5] 51, 97, 98, 160, 162 💬
36 Hematopoietic cell lineage 💬
 [1] IL5 💬 D04923 💬 Mepolizumab [4] 44, 45, 98, 162 💬
37 Hematopoietic cell lineage 💬
 [1] IL5 💬 D08985 💬 Reslizumab [2] 44, 98 💬
38 Hematopoietic cell lineage 💬
 [1] IL5RA 💬 D09874 💬 Benralizumab [5] 44, 45, 98, 162, 299 💬
39 Hematopoietic cell lineage 💬
 [1] IL6 💬 D12487 💬 Olokizumab [2] 46, 96 💬
40 Hematopoietic cell lineage 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
41 Hematopoietic cell lineage 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
42 Hematopoietic cell lineage 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
43 Hematopoietic cell lineage 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
44 Hematopoietic cell lineage 💬
 [1] IL6R 💬 D11079 💬 Satralizumab [3] 11, 13, 86 💬
45 Hematopoietic cell lineage 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [21]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
46 Hematopoietic cell lineage 💬
 [1] ITGA4 💬 D10540 💬 Abrilumab [2] 96, 97 💬
47 Hematopoietic cell lineage 💬
 [1] ITGA4 💬 D06590 💬 Firategrast [1] 13 💬
48 Hematopoietic cell lineage 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
49 Hematopoietic cell lineage 💬
 [1] ITGA4 💬 D08083 💬 Vedolizumab [3] 94, 96, 97 💬
50 Hematopoietic cell lineage 💬
 [1] KIT 💬 D03658 💬 Dasatinib [2] 51, 85 💬
51 Hematopoietic cell lineage 💬
 [1] KIT 💬 D06414 💬 Dasatinib [2] 51, 85 💬
52 Hematopoietic cell lineage 💬
 [1] KIT 💬 D08066 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
53 Hematopoietic cell lineage 💬
 [1] KIT 💬 D10229 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
54 Hematopoietic cell lineage 💬
 [1] KIT 💬 D08953 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
55 Hematopoietic cell lineage 💬
 [1] MME 💬 D10225 💬 Sacubitril [2] 58, 222 💬
56 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D09321 💬 Obinutuzumab [4] 43, 44, 49, 222 💬
57 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D05218 💬 Ocrelizumab [3] 13, 46, 49 💬
58 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D09314 💬 Ofatumumab [3] 13, 35, 46 💬
59 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D02994 💬 Rituximab [48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
60 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D11243 💬 Ublituximab [1] 13 💬
61 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D09031 💬 Veltuzumab [1] 46 💬
62 Hematopoietic cell lineage 💬
 [1] TFRC 💬 D11812 💬 Pabinafusp alfa [1] 19 💬
63 Hematopoietic cell lineage 💬
 [1] TNF 💬 D02597 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
64 Hematopoietic cell lineage 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
65 Hematopoietic cell lineage 💬
 [1] TNF 💬 D00742 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
66 Hematopoietic cell lineage 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
67 Hematopoietic cell lineage 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
68 Hematopoietic cell lineage 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
69 Hematopoietic cell lineage 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
70 Hematopoietic cell lineage 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
71 Hematopoietic cell lineage 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬