Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Bile secretion 💬
[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00297 💬 Digitoxin [1] 299 💬
2 Bile secretion 💬
[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00298 💬 Digoxin [3]  8 , 46, 210 💬
3 Bile secretion 💬
[1] CA2 💬 D00218 💬 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230 💬
4 Bile secretion 💬
[1] CA2 💬 D00518 💬 Diclofenamide [1] 114 💬
5 Bile secretion 💬
[1] CA2 💬 D07871 💬 Dorzolamide [1] 90 💬
6 Bile secretion 💬
[1] CA2 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
7 Bile secretion 💬
[1] CFTR 💬 D11423 💬 Deutivacaftor [1] 299 💬
8 Bile secretion 💬
[1] CFTR 💬 D11507 💬 Elexacaftor [1] 299 💬
9 Bile secretion 💬
[1] CFTR 💬 D11724 💬 Galicaftor [1] 299 💬
10 Bile secretion 💬
[1] CFTR 💬 D09916 💬 Ivacaftor [1] 299 💬
11 Bile secretion 💬
[1] CFTR 💬 D10134 💬 Lumacaftor [1] 299 💬
12 Bile secretion 💬
[1] CFTR 💬 D11041 💬 Tezacaftor [1] 299 💬
13 Bile secretion 💬
[1] HMGCR 💬 D07474 💬 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
14 Bile secretion 💬
[1] HMGCR 💬 D07983 💬 Fluvastatin [3] 79, 218, 222 💬
15 Bile secretion 💬
[1] HMGCR 💬 D00359 💬 Lovastatin [11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
16 Bile secretion 💬
[1] HMGCR 💬 D08410 💬 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
17 Bile secretion 💬
[1] HMGCR 💬 D08492 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
18 Bile secretion 💬
[1] HMGCR 💬 D00434 💬 Simvastatin [21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
19 Bile secretion 💬
[1] NR1H4 💬 D00163 💬 Chenodeoxycholic acid [4] 20, 96, 234, 263 💬
20 Bile secretion 💬
[1] NR1H4 💬 D10699 💬 Cholic Acid [4] 20, 234, 265, 310 💬
21 Bile secretion 💬
[1] NR1H4 💬 D09360 💬 Obeticholic acid [3] 93, 265, 296 💬
22 Bile secretion 💬
[1] NR1H4 💬 D11548 💬 Tropifexor [1] 93 💬
23 Bile secretion 💬
[1] NR1H4 💬 D00734 💬 Ursodeoxycholic acid [14]  6 ,  8 , 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
24 Bile secretion 💬
[1] RXRA 💬 D02754 💬 Acitretin [1] 37 💬
25 Bile secretion 💬
[1] RXRA 💬 D02815 💬 Alitretinoin [1] 49 💬
26 Bile secretion 💬
[1] RXRA 💬 D03106 💬 Bexarotene [2] 13, 75 💬
27 Bile secretion 💬
[2] SLC10A1, SLC10A2 💬 D10951 💬 Maralixibat [3] 296, 297, 338 💬
28 Bile secretion 💬
[1] SLC10A2 💬 D10796 💬 Elobixibat [1]  6  💬
29 Bile secretion 💬
[1] SLC10A2 💬 D11716 💬 Odevixibat [3] 296, 297, 338 💬