Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
2 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 D01173 💬 Cilnidipine [1] 67 💬
3 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
4 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 D00349 💬 Isradipine [1]  6  💬
5 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 D08270 💬 Nicardipine [2] 70, 86 💬
6 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 D00437 💬 Nifedipine [2] 50, 81 💬
7 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 D01908 💬 Nilvadipine [1] 90 💬
8 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 D08340 💬 Perhexiline [2] 58, 272 💬
9 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 D08441 💬 Propiverine [1] 226 💬
10 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 D02356 💬 Verapamil [4] 58, 96, 140, 167 💬
11 Amphetamine addiction 💬
 [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
12 Amphetamine addiction 💬
 [1] DDC 💬 D03082 💬 Benserazide [1]  6  💬
13 Amphetamine addiction 💬
 [1] DDC 💬 D00558 💬 Carbidopa [7]  6 , 13, 17, 90, 140, 164, 201 💬
14 Amphetamine addiction 💬
 [1] DRD1 💬 D07460 💬 Apomorphine [3]  5 ,  6 ,  7  💬
15 Amphetamine addiction 💬
 [1] DRD1 💬 D09886 💬 Dexpramipexole [1]  2  💬
16 Amphetamine addiction 💬
 [1] DRD1 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
17 Amphetamine addiction 💬
 [1] DRD1 💬 D01044 💬 Flupentixol [1] 97 💬
18 Amphetamine addiction 💬
 [1] DRD1 💬 D11839 💬 Foslevodopa [1]  6  💬
19 Amphetamine addiction 💬
 [1] DRD1 💬 D00059 💬 Levodopa [6]  6 , 17, 90, 140, 164, 201 💬
20 Amphetamine addiction 💬
 [1] DRD1 💬 D08339 💬 Pergolide [1]  6  💬
21 Amphetamine addiction 💬
 [1] DRD1 💬 D11431 💬 Tavapadon [1]  6  💬
22 Amphetamine addiction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
23 Amphetamine addiction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D02696 💬 Talampanel [2]  2 ,  6  💬
24 Amphetamine addiction 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
25 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07058 💬 Acamprosate [2]  6 , 206 💬
26 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07441 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
27 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D03742 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
28 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
29 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
30 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D09917 💬 Latrepirdine [1]  8  💬
31 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
32 Amphetamine addiction 💬
 [2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
33 Amphetamine addiction 💬
 [1] MAOA 💬 D02561 💬 Moclobemide [1]  6  💬
34 Amphetamine addiction 💬
 [2] MAOA, MAOB 💬 D02579 💬 Iproniazid [1]  6  💬
35 Amphetamine addiction 💬
 [2] MAOA, MAOB 💬 D08349 💬 Phenelzine [1]  6  💬
36 Amphetamine addiction 💬
 [3] MAOA, MAOB, SLC6A3 💬 D05458 💬 Phentermine [1] 97 💬
37 Amphetamine addiction 💬
 [1] MAOB 💬 D08469 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
38 Amphetamine addiction 💬
 [1] MAOB 💬 D10829 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
39 Amphetamine addiction 💬
 [1] MAOB 💬 D10158 💬 Safinamide [2]  6 , 17 💬
40 Amphetamine addiction 💬
 [1] MAOB 💬 D03731 💬 Selegiline [1]  6  💬
41 Amphetamine addiction 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
42 Amphetamine addiction 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
43 Amphetamine addiction 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
44 Amphetamine addiction 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
45 Amphetamine addiction 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [2] 49, 222 💬
46 Amphetamine addiction 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
47 Amphetamine addiction 💬
 [1] SLC18A2 💬 D10701 💬 Deutetrabenazine [1]  8  💬
48 Amphetamine addiction 💬
 [1] SLC18A2 💬 D08575 💬 Tetrabenazine [1]  8  💬
49 Amphetamine addiction 💬
 [1] SLC18A2 💬 D10675 💬 Valbenazine [1]  8  💬
50 Amphetamine addiction 💬
 [1] SLC6A3 💬 D03215 💬 Armodafinil [3]  6 , 13, 84 💬
51 Amphetamine addiction 💬
 [1] SLC6A3 💬 D07591 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
52 Amphetamine addiction 💬
 [1] SLC6A3 💬 D08130 💬 Lisdexamfetamine [1] 13 💬
53 Amphetamine addiction 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬