Propofol ( DrugBank: Propofol )

8 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
6	パーキンソン病	8
21	ミトコンドリア病	1
22	もやもや病	1
34	神経線維腫症	1
46	悪性関節リウマチ	1
70	広範脊柱管狭窄症	2
98	好酸球性消化管疾患	1
296	胆道閉鎖症	2

6. パーキンソン病

臨床試験数 : 2,307 / 薬物数 : 2,007 - (DrugBank : 349) / 標的遺伝子数 : 188 - 標的パスウェイ数 : 199

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000039697	2020-11-15	2020-11-06	Application of etomidate in deep brain stimulation under general anesthesia for Parkinson's disease	Application of etomidate in deep brain stimulation under general anesthesia for Parkinson's disease	Parkinson Disease	Experimental group:Etomidate-based anesthesia;Control group: Propofol-based anesthesia;	Department of Anesthesiology, the First Affiliated Hospital of Sun Yat-Sen University	NULL	Recruiting	18	80	Both	Experimental group:30;Control group:30;	Phase 4	China
2	NCT04502550 (ClinicalTrials.gov)	October 15, 2020	30/7/2020	Brain Networks and Consciousness	Subcortical-cortical Network Dynamics of Anesthesia and Consciousness	Loss of Consciousness;Parkinson Disease;Essential Tremor;Anesthesia	Drug: Propofol	University of Texas Southwestern Medical Center	University of California, Los Angeles	Recruiting	18 Years	N/A	All	144		United States
3	ChiCTR1900021760	2019-03-09	2019-03-08	Effect-site concentration of remifentanil for I-gel insertion in male patients with Parkinson’s disease undergoing deep brain stimulator implantation during target-controlled infusion of propofol	Effect-site concentration of remifentanil for I-gel insertion in male patients with Parkinson’s disease undergoing deep brain stimulator implantation during target-controlled infusion of propofol	Parkinson’s disease	Parkinson’s disease:propofol and remifentanil;Non-Parkinson’s disease:propofol and remifentanil;	The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China	NULL	Recruiting	40	64	Male	Parkinson’s disease:25;Non-Parkinson’s disease:25;	N/A	China
4	ChiCTR1800014542	2018-01-22	2018-01-20	Up-down sequential testing of propofol - induced half-effective dose ( ed50 ) in patients with Parkinson's disease and non - Parkinson's disease	Up-down sequential testing of propofol - induced half-effective dose ( ed50 ) in patients with Parkinson's disease and non - Parkinson's disease	Parkinson's Disease	PD group:propofol;NPD group:propofol;	Xuanwu Hospital of CCMU	NULL	Recruiting	18	65	Both	PD group:40;NPD group:40;		China
5	ChiCTR-IOR-16010168	2016-12-20	2016-12-15	Propofol-remifetanyl vs dexmedetomidine continous infusion for deep brain stimulation implantation	Propofol-remifetanyl vs dexmedetomidine continous infusion for deep brain stimulation implantation	Parkinson's Disease	propofol-remifentanyl group:propofol-remifentany infusion for monitored anesthesia care during awake deep brain stimulation surgery;dexmedetomidine group:dexmedetomidine infusion for monitored anesthesia care during awake deep brain stimulation surgery;	West China Hospital, Sichuan University	NULL	Recruiting	18		Both	propofol-remifentanyl group:25;dexmedetomidine group:25;		China
6	NCT02256319 (ClinicalTrials.gov)	September 2014	30/9/2014	Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity Measured Through Implanted Stimulators	Effects of Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity (Local Field Potentials) Measured Through Implanted Stimulators	Parkinson's Disease	Drug: Dexmedetomidine;Drug: Propofol	Clinica Universidad de Navarra, Universidad de Navarra	NULL	Completed	18 Years	N/A	Both	12	Phase 4	Spain
7	EUCTR2014-000868-17-ES (EUCTR)	26/06/2014	17/03/2014	Effect of dexmedetomidine vs propofol on basal ganglia activity (local field potentials) recorded through implanted stimulators	Effect of dexmedetomidine vs propofol on basal ganglia activity (local field potentials) recorded through implanted stimulators	Parkinson's disease MedDRA version: 16.1;Level: LLT;Classification code 10013113;Term: Disease Parkinson's;System Organ Class: 100000004852;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]	Trade Name: Dexdor Product Name: Dexdor INN or Proposed INN: DEXMEDETOMIDINE Other descriptive name: DEXMEDETOMIDINA Trade Name: Propofol-Lipuro Product Name: Propofol-Lipuro INN or Proposed INN: PROPOFOL Other descriptive name: PROPOFOL	Clínica Universidad de Navarra/Universidad de Navarra	NULL	Not Recruiting			Female: yes Male: yes			Spain
8	NCT00615472 (ClinicalTrials.gov)	October 2003	9/1/2008	Intravenous Versus Inhalational Anesthesia in Parkinson's Disease	Intravenous General Anesthesia Versus Inhalational General Anesthesia in Parkinson's Disease	Parkinson's Disease	Drug: Isoflurane;Drug: Remifentanil;Drug: Propofol	Columbia University	NULL	Terminated	18 Years	N/A	All	58	N/A	United States

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21. ミトコンドリア病

臨床試験数 : 39 / 薬物数 : 42 - (DrugBank : 32) / 標的遺伝子数 : 47 - 標的パスウェイ数 : 67

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02053766 (ClinicalTrials.gov)	January 10, 2014	31/1/2014	Anesthesia in Patients With Mitochondrial Disease	Anesthesia in Patients With Mitochondrial Disease	Mitochondrial Diseases	Drug: Sevoflurane;Drug: Dexmedetomidine;Drug: Propofol	The University of Texas Health Science Center, Houston	NULL	Recruiting	N/A	17 Years	All	60	N/A	United States

22. もやもや病

臨床試験数 : 17 / 薬物数 : 22 - (DrugBank : 17) / 標的遺伝子数 : 33 - 標的パスウェイ数 : 45

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR1900027197	2019-05-01	2019-11-04	Study on the protective effect of desflurane combined with propofol on the brain of patients with moyamoya disease undergoing cerebral revascularization	Study for the protective effect of desflurane on the brain of patients with moyamoya disease	Moyamoya disease	Group D:Desflurane for anesthesia maintenance;GroupP:Propofol;GroupPD:Desflurane and propofol;	The First Affiliated Hospital of Zhengzhou University	NULL	Completed	20	65	Both	Group D:30;GroupP:30;GroupPD:30;	Phase 4	China

34. 神経線維腫症

臨床試験数 : 133 / 薬物数 : 186 - (DrugBank : 67) / 標的遺伝子数 : 79 - 標的パスウェイ数 : 190

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03513757 (ClinicalTrials.gov)	March 4, 2018	4/2/2018	Dexmedetomidine and Propofol for Pediatric MRI Sedation	An Observer-blinded Randomized Study of Propofol Infusion vs Bolus Dexmedetomidine and Propofol Sedation for Pediatric Magnetic Resonance Imaging	Headache;Tumor;Seizure Disorder;Neurofibromatoses;Hydrocephalus;Abdominal Neoplasm;Spine Deformity	Drug: propofol;Drug: Dexmedetomidine;Drug: Glycopyrrolate;Drug: Lidocaine 1% Injectable Solution;Drug: Nitrous Oxide;Drug: Sevoflurane	Medical College of Wisconsin	NULL	Completed	12 Months	60 Months	All	40	Phase 4	United States

46. 悪性関節リウマチ

臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2016-002035-15-FI (EUCTR)	20/05/2016	12/05/2016	Outcome after total knee endoprosthesis under general or regional anesthesia, a randomized study	Outcome after total knee arthroplasty under general or spinal anesthesia, a randomized study - Outcome after total knee arthroplasty under general or spinal anesthesia	Patients undego total knee arthroplasty operation in general or spinal anaesthesia because of osteoarthritis, rheumatoid arthritis or other degenerative condition of the knee MedDRA version: 19.0;Level: LLT;Classification code 10031174;Term: Osteoarthrosis;System Organ Class: 100000004859 MedDRA version: 19.0;Classification code 10031158;Term: Osteo arthritis knees;System Organ Class: 100000004859;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]	Trade Name: Bicain spinal INN or Proposed INN: bupivacaine hydrochloride Other descriptive name: BUPIVACAINE HYDROCHLORIDE Trade Name: Propolipid INN or Proposed INN: propofol Other descriptive name: PROPOFOL	Helsinki University Central Hospital	NULL	Not Recruiting			Female: yes Male: yes	400	Phase 4	Finland

70. 広範脊柱管狭窄症

臨床試験数 : 95 / 薬物数 : 169 - (DrugBank : 61) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 90

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2200058808	2022-04-16	2022-04-17	Effect of multimodal brain monitoring-guided anesthesia on incidence of postoperative cognitive dysfunction in elderly following spinal surgery	Effect of multimodal brain monitoring-guided anesthesia on incidence of postoperative cognitive dysfunction in elderly following spinal surgery	Thoracic/lumbar spinal stenosis or lumbar disc herniation	BIS guided anesthesia management group:The dosage of propofol is adjusted guided by BIS value;Multimodal brain monitoring-guided anesthesia management group:Multimodal brain monitoring-guided anesthesia;	Beijing Municipal Geriatric Medical Research Center	NULL	Recruiting	65	100	Both	BIS guided anesthesia management group:94;Multimodal brain monitoring-guided anesthesia management group:94;		China
2	NCT04992572 (ClinicalTrials.gov)	December 1, 2021	21/7/2021	Study Comparing Local/ MAC Anesthesia in Lumbar Decompression	Randomized Study Comparing Local/ MAC Anesthesia to General for 1-3 Level Lumbar Decompressions	Lumbar Spinal Stenosis	Drug: Propofol Injection;Drug: Lidocaine Hydrochloride, Injectable	Stanford University	NULL	Recruiting	40 Years	95 Years	All	100	Early Phase 1	United States

98. 好酸球性消化管疾患

臨床試験数 : 172 / 薬物数 : 149 - (DrugBank : 39) / 標的遺伝子数 : 38 - 標的パスウェイ数 : 135

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02038894 (ClinicalTrials.gov)	December 2009	1/5/2013	Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies	Comparison Of Different Anesthetic Techniques In Children Undergoing Esophagogastroduodenoscopies	Eosinophilic Esophagitis	Drug: Intubated with Sevoflurane (IS);Drug: Intubated with Propofol (IP);Drug: Zofran - no intubation;Drug: Propofol	Children's Hospital Medical Center, Cincinnati	NULL	Completed	1 Year	12 Years	All	179	N/A	United States

296. 胆道閉鎖症

臨床試験数 : 71 / 薬物数 : 70 - (DrugBank : 39) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 60

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR-IOR-17013585	2018-06-14	2017-11-24	Comparison of renal injury in children with liver transplantation under combined anesthesia with sevoflurane and propofol	The influence of sevoflurane and propofol on acute kidney injury in pediatric living donor liver transplantion	Congenital biliary atresia	P:Propofol compound anesthesia;Se:Sevoflurane compound anesthesia;	Tianjin First Central Hospital	NULL	Recruiting	0.5	2	Both	P:60;Se:60;		China
2	ChiCTR1800015778	2018-04-20	2018-04-20	Myocardial protection in pediatric patients undergoing liver transplantation	Myocardial protective strategies of pediatric liver transplantation with biliary atresia	Congenital biliary atresia	Propofol:Propofol compound anesthesia;Sev:Sev compound anesthesia;	Tianjin First Center Hospital	NULL	Recruiting	0	2	Both	Propofol:60;Sev:60;		China

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