DDrare: Database of Drug Development for Rare Diseases

Prior donepezil 5mg (DrugBank: Donepezil)

9 diseases

ID	Disease name (Link within this page)	Number of trials
5	Progressive supranuclear palsy	0
6	Parkinson disease	1
13	Multiple sclerosis/Neuromyelitis optica	0
46	Malignant rheumatoid arthritis	0
78	Hypopituitarism	0
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy	0
127	Frontotemporal lobar degeneration	0
156	Rett syndrome	0
206	Fragile X syndrome	0

5. Progressive supranuclear palsy [ 82 clinical trials, 107 drugs, (DrugBank: 36 drugs), 60 drug target genes, 90 drug target pathways]

Searched query = "Progressive supranuclear palsy", "PSP"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 82 trial found

6. Parkinson disease [ 2,123 clinical trials, 2,046 drugs, (DrugBank: 324 drugs), 183 drug target genes, 198 drug target pathways]

Searched query = "Parkinson disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 2,123 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01327859 (ClinicalTrials.gov)	March 2003	30/3/2011	Safety, Tolerability, and Efficacy of Donepezil (Aricept) in Parkinson' s Disease (PD) Patients With Dementia	A 52-week, Multicentre Open Label Extension Study of the Safety Tolerability and Efficacy of Donepezil (Aricept) in Parkinson's Disease (PD) Patients With Dementia	Parkinson's Disease;Dementia	Drug: Prior Donepezil 5mg;Drug: Prior Donzepezil 10mg;Drug: Prior Placebo	Eisai Inc.	NULL	Completed	40 Years	N/A	Both	357	Phase 3	United Kingdom

13. Multiple sclerosis/Neuromyelitis optica [ 3,050 clinical trials, 2,147 drugs, (DrugBank: 348 drugs), 244 drug target genes, 228 drug target pathways]

Searched query = "Multiple sclerosis/Neuromyelitis optica", "Multiple sclerosis", "Neuromyelitis optica", "MS", "NMOSD", "Devic disease", "Balo concentric sclerosis", "Baló concentric sclerosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 3,050 trial found

46. Malignant rheumatoid arthritis [ 4,183 clinical trials, 2,538 drugs, (DrugBank: 401 drugs), 183 drug target genes, 219 drug target pathways]

Searched query = "Malignant rheumatoid arthritis", "Rheumatoid arthritis", "Rheumatoid arthritis with vasculitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 4,183 trial found

78. Hypopituitarism [ 462 clinical trials, 346 drugs, (DrugBank: 45 drugs), 41 drug target genes, 80 drug target pathways]

Searched query = "Hypopituitarism", "Anterior pituitary hypothyroidism", "Syndrome of abnormal secretion of gonadotropin", "Hyposecretion of gonadotropins", "Adrenocorticotropic hormone deficiency", "ACTH deficiency", "Thyroid-stimulating hormone deficiency", "TSH deficiency", "Growth hormone deficiency", "GH deficiency", "GHD", "CGHD", "AGHD", "Prolactin deficiency", "PRL deficiency"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 462 trial found

124. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [ 11 clinical trials, 13 drugs, (DrugBank: 4 drugs), 3 drug target genes, 11 drug target pathways]

Searched query = "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy", "CADASIL", "Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy", "Autosomal dominant cerebral artery disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 11 trial found

127. Frontotemporal lobar degeneration [ 74 clinical trials, 83 drugs, (DrugBank: 28 drugs), 29 drug target genes, 99 drug target pathways]

Searched query = "Frontotemporal lobar degeneration", "Frontotemporal dementia", "Semantic dementia"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 74 trial found

156. Rett syndrome [ 36 clinical trials, 49 drugs, (DrugBank: 19 drugs), 77 drug target genes, 112 drug target pathways]

Searched query = "Rett syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 36 trial found

206. Fragile X syndrome [ 98 clinical trials, 73 drugs, (DrugBank: 27 drugs), 46 drug target genes, 57 drug target pathways]

Searched query = "Fragile X syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 98 trial found