Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alanine, aspartate and glutamate metabolism 💬
 [1] ABAT 💬 D00535 💬 Vigabatrin [2] 145, 158 💬
2 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
3 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
4 beta-Alanine metabolism 💬
 [1] ABAT 💬 D00535 💬 Vigabatrin [2] 145, 158 💬
5 Butanoate metabolism 💬
 [1] ABAT 💬 D00535 💬 Vigabatrin [2] 145, 158 💬
6 Calcium signaling pathway 💬
 [3] HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine [4] 140, 144, 145, 149 💬
7 cAMP signaling pathway 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
8 cAMP signaling pathway 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
9 Circadian entrainment 💬
 [2] MTNR1A, MTNR1B 💬 D08170 💬 Melatonin [12]  6 ,  8 , 13, 37, 46, 49, 90, 97, 144, 145, 149, 202 💬
10 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
11 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
12 Cushing syndrome 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
13 Cushing syndrome 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
14 GABAergic synapse 💬
 [1] ABAT 💬 D00535 💬 Vigabatrin [2] 145, 158 💬
15 GABAergic synapse 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D04300 💬 Ganaxolone [4] 145, 152, 158, 206 💬
16 Gap junction 💬
 [3] HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine [4] 140, 144, 145, 149 💬
17 Inflammatory mediator regulation of TRP channels 💬
 [3] HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine [4] 140, 144, 145, 149 💬
18 Metabolic pathways 💬
 [1] ABAT 💬 D00535 💬 Vigabatrin [2] 145, 158 💬
19 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D04300 💬 Ganaxolone [4] 145, 152, 158, 206 💬
20 Neuroactive ligand-receptor interaction 💬
 [2] CNR1, CNR2 💬 D10915 💬 Cannabidiol [19]  2 ,  6 ,  8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
21 Neuroactive ligand-receptor interaction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D04300 💬 Ganaxolone [4] 145, 152, 158, 206 💬
22 Neuroactive ligand-receptor interaction 💬
 [3] HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine [4] 140, 144, 145, 149 💬
23 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
24 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
25 Neuroactive ligand-receptor interaction 💬
 [2] MTNR1A, MTNR1B 💬 D08170 💬 Melatonin [12]  6 ,  8 , 13, 37, 46, 49, 90, 97, 144, 145, 149, 202 💬
26 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00407 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
27 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00751 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
28 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00979 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
29 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05000 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
30 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05001 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
31 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05002 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
32 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00472 💬 Prednisolone [43]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307 💬
33 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00980 💬 Prednisolone [43]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307 💬
34 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00981 💬 Prednisolone [43]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307 💬
35 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00982 💬 Prednisolone [43]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307 💬
36 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01239 💬 Prednisolone [43]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307 💬
37 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01998 💬 Prednisolone [43]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307 💬
38 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D02156 💬 Prednisolone [43]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307 💬
39 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D03301 💬 Prednisolone [43]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307 💬
40 Nicotine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D04300 💬 Ganaxolone [4] 145, 152, 158, 206 💬
41 Propanoate metabolism 💬
 [1] ABAT 💬 D00535 💬 Vigabatrin [2] 145, 158 💬
42 Rap1 signaling pathway 💬
 [1] CNR1 💬 D10915 💬 Cannabidiol [19]  2 ,  6 ,  8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
43 Retrograde endocannabinoid signaling 💬
 [1] CNR1 💬 D10915 💬 Cannabidiol [19]  2 ,  6 ,  8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
44 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D04300 💬 Ganaxolone [4] 145, 152, 158, 206 💬
45 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 D04300 💬 Ganaxolone [4] 145, 152, 158, 206 💬
46 Serotonergic synapse 💬
 [4] HTR2A, HTR2B, HTR2C, SLC6A4 💬 D07945 💬 Fenfluramine [4] 140, 144, 145, 149 💬
47 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 D07945 💬 Fenfluramine [4] 140, 144, 145, 149 💬
48 Taste transduction 💬
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 D04300 💬 Ganaxolone [4] 145, 152, 158, 206 💬
49 Thermogenesis 💬
 [1] CNR1 💬 D10915 💬 Cannabidiol [19]  2 ,  6 ,  8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
50 Valine, leucine and isoleucine degradation 💬
 [1] ABAT 💬 D00535 💬 Vigabatrin [2] 145, 158 💬

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