Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Antifolate resistance 💬	[2] DHFR, DHFR2 💬	D00142 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
2	Antifolate resistance 💬	[2] DHFR, DHFR2 💬	D02115 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
3	Biosynthesis of cofactors 💬	[1] ALPL 💬	D10595 💬	Asfotase alfa	[1] 172 💬
4	Biosynthesis of cofactors 💬	[2] DHFR, DHFR2 💬	D00142 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
5	Biosynthesis of cofactors 💬	[2] DHFR, DHFR2 💬	D02115 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
6	Folate biosynthesis 💬	[1] ALPL 💬	D10595 💬	Asfotase alfa	[1] 172 💬
7	Folate biosynthesis 💬	[2] DHFR, DHFR2 💬	D00142 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
8	Folate biosynthesis 💬	[2] DHFR, DHFR2 💬	D02115 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
9	Metabolic pathways 💬	[1] ALPL 💬	D10595 💬	Asfotase alfa	[1] 172 💬
10	Metabolic pathways 💬	[2] DHFR, DHFR2 💬	D00142 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
11	Metabolic pathways 💬	[2] DHFR, DHFR2 💬	D02115 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
12	One carbon pool by folate 💬	[2] DHFR, DHFR2 💬	D00142 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
13	One carbon pool by folate 💬	[2] DHFR, DHFR2 💬	D02115 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
14	Thiamine metabolism 💬	[1] ALPL 💬	D10595 💬	Asfotase alfa	[1] 172 💬