Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00511 💬 Phenylephrine [1] 22 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08365 💬 Phenylephrine [1] 22 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00076 💬 Norepinephrine [1] 22 💬
4 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D05206 💬 Norepinephrine [1] 22 💬
5 Alzheimer disease 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
6 AMPK signaling pathway 💬
 [1] ADRA1A 💬 D00076 💬 Norepinephrine [1] 22 💬
7 AMPK signaling pathway 💬
 [1] ADRA1A 💬 D05206 💬 Norepinephrine [1] 22 💬
8 AMPK signaling pathway 💬
 [1] ADRA1A 💬 D00511 💬 Phenylephrine [1] 22 💬
9 AMPK signaling pathway 💬
 [1] ADRA1A 💬 D08365 💬 Phenylephrine [1] 22 💬
10 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
11 C-type lectin receptor signaling pathway 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
12 Calcium signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00511 💬 Phenylephrine [1] 22 💬
13 Calcium signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08365 💬 Phenylephrine [1] 22 💬
14 Calcium signaling pathway 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine [1] 22 💬
15 Calcium signaling pathway 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 💬 D05206 💬 Norepinephrine [1] 22 💬
16 cAMP signaling pathway 💬
 [2] ADRB1, ADRB2 💬 D00076 💬 Norepinephrine [1] 22 💬
17 cAMP signaling pathway 💬
 [2] ADRB1, ADRB2 💬 D05206 💬 Norepinephrine [1] 22 💬
18 cGMP-PKG signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00511 💬 Phenylephrine [1] 22 💬
19 cGMP-PKG signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08365 💬 Phenylephrine [1] 22 💬
20 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine [1] 22 💬
21 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D05206 💬 Norepinephrine [1] 22 💬
22 Chemical carcinogenesis - DNA adducts 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
23 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine [1] 22 💬
24 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 D05206 💬 Norepinephrine [1] 22 💬
25 Cytokine-cytokine receptor interaction 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
26 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 D00076 💬 Norepinephrine [1] 22 💬
27 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 D05206 💬 Norepinephrine [1] 22 💬
28 GABAergic synapse 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol [10]  6 , 21, 22, 34, 46, 70, 75, 84, 98, 296 💬
29 Gap junction 💬
 [1] ADRB1 💬 D00076 💬 Norepinephrine [1] 22 💬
30 Gap junction 💬
 [1] ADRB1 💬 D05206 💬 Norepinephrine [1] 22 💬
31 Hematopoietic cell lineage 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
32 Human cytomegalovirus infection 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
33 Human papillomavirus infection 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
34 IL-17 signaling pathway 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
35 JAK-STAT signaling pathway 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
36 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
37 Leishmaniasis 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
38 Metabolic pathways 💬
 [2] PTGS1, PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
39 MicroRNAs in cancer 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
40 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol [10]  6 , 21, 22, 34, 46, 70, 75, 84, 98, 296 💬
41 Neuroactive ligand-receptor interaction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00511 💬 Phenylephrine [1] 22 💬
42 Neuroactive ligand-receptor interaction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08365 💬 Phenylephrine [1] 22 💬
43 Neuroactive ligand-receptor interaction 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine [1] 22 💬
44 Neuroactive ligand-receptor interaction 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D05206 💬 Norepinephrine [1] 22 💬
45 Neuroactive ligand-receptor interaction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol [10]  6 , 21, 22, 34, 46, 70, 75, 84, 98, 296 💬
46 NF-kappa B signaling pathway 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
47 Nicotine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol [10]  6 , 21, 22, 34, 46, 70, 75, 84, 98, 296 💬
48 Ovarian steroidogenesis 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
49 Oxytocin signaling pathway 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
50 Pathways in cancer 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
51 Pathways in cancer 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
52 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
53 PI3K-Akt signaling pathway 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
54 Platelet activation 💬
 [1] PTGS1 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
55 Regulation of lipolysis in adipocytes 💬
 [3] ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine [1] 22 💬
56 Regulation of lipolysis in adipocytes 💬
 [3] ADRB1, ADRB2, ADRB3 💬 D05206 💬 Norepinephrine [1] 22 💬
57 Regulation of lipolysis in adipocytes 💬
 [2] PTGS1, PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
58 Renin secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine [1] 22 💬
59 Renin secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 D05206 💬 Norepinephrine [1] 22 💬
60 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol [10]  6 , 21, 22, 34, 46, 70, 75, 84, 98, 296 💬
61 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
62 Salivary secretion 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00511 💬 Phenylephrine [1] 22 💬
63 Salivary secretion 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08365 💬 Phenylephrine [1] 22 💬
64 Salivary secretion 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine [1] 22 💬
65 Salivary secretion 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 💬 D05206 💬 Norepinephrine [1] 22 💬
66 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 D00549 💬 Propofol [10]  6 , 21, 22, 34, 46, 70, 75, 84, 98, 296 💬
67 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
68 Small cell lung cancer 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
69 Taste transduction 💬
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 D00549 💬 Propofol [10]  6 , 21, 22, 34, 46, 70, 75, 84, 98, 296 💬
70 Thermogenesis 💬
 [1] ADRB3 💬 D00076 💬 Norepinephrine [1] 22 💬
71 Thermogenesis 💬
 [1] ADRB3 💬 D05206 💬 Norepinephrine [1] 22 💬
72 TNF signaling pathway 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
73 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00076 💬 Norepinephrine [1] 22 💬
74 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D05206 💬 Norepinephrine [1] 22 💬
75 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00511 💬 Phenylephrine [1] 22 💬
76 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08365 💬 Phenylephrine [1] 22 💬
77 VEGF signaling pathway 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬

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