Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00680 💬 Methylergometrine [3] 118, 280, 288 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08207 💬 Methylergometrine [3] 118, 280, 288 💬
3 Alzheimer disease 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [16] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331 💬
4 AMPK signaling pathway 💬
 [1] ADRA1A 💬 D00680 💬 Methylergometrine [3] 118, 280, 288 💬
5 AMPK signaling pathway 💬
 [1] ADRA1A 💬 D08207 💬 Methylergometrine [3] 118, 280, 288 💬
6 AMPK signaling pathway 💬
 [1] HMGCR 💬 D00434 💬 Simvastatin [21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
7 Amyotrophic lateral sclerosis 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [16] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331 💬
8 Bile secretion 💬
 [1] HMGCR 💬 D00434 💬 Simvastatin [21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
9 Calcium signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00680 💬 Methylergometrine [3] 118, 280, 288 💬
10 Calcium signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08207 💬 Methylergometrine [3] 118, 280, 288 💬
11 cGMP-PKG signaling pathway 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C 💬 D00680 💬 Methylergometrine [3] 118, 280, 288 💬
12 cGMP-PKG signaling pathway 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C 💬 D08207 💬 Methylergometrine [3] 118, 280, 288 💬
13 Complement and coagulation cascades 💬
 [2] F10, F9 💬 D10821 💬 Emicizumab [1] 288 💬
14 Complement and coagulation cascades 💬
 [1] F8 💬 D00291 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
15 Complement and coagulation cascades 💬
 [1] F8 💬 D02235 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
16 Complement and coagulation cascades 💬
 [1] PLG 💬 D01136 💬 Tranexamic acid [6] 46, 70, 215, 227, 288, 299 💬
17 Complement and coagulation cascades 💬
 [2] SERPINC1, SERPIND1 💬 D08547 💬 Sulodexide [4] 13, 51, 271, 288 💬
18 Cytokine-cytokine receptor interaction 💬
 [1] IL11RA 💬 D05266 💬 Oprelvekin [2] 96, 288 💬
19 Hematopoietic cell lineage 💬
 [1] IL11RA 💬 D05266 💬 Oprelvekin [2] 96, 288 💬
20 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D02994 💬 Rituximab [49]  6 , 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
21 Huntington disease 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [16] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331 💬
22 Influenza A 💬
 [1] PLG 💬 D01136 💬 Tranexamic acid [6] 46, 70, 215, 227, 288, 299 💬
23 JAK-STAT signaling pathway 💬
 [1] IL11RA 💬 D05266 💬 Oprelvekin [2] 96, 288 💬
24 Metabolic pathways 💬
 [1] HMGCR 💬 D00434 💬 Simvastatin [21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
25 Neuroactive ligand-receptor interaction 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C 💬 D00680 💬 Methylergometrine [3] 118, 280, 288 💬
26 Neuroactive ligand-receptor interaction 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C 💬 D08207 💬 Methylergometrine [3] 118, 280, 288 💬
27 Neuroactive ligand-receptor interaction 💬
 [1] AVPR2 💬 D00291 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
28 Neuroactive ligand-receptor interaction 💬
 [1] AVPR2 💬 D02235 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
29 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00473 💬 Prednisone [48]  2 ,  6 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 💬
30 Neuroactive ligand-receptor interaction 💬
 [1] PLG 💬 D01136 💬 Tranexamic acid [6] 46, 70, 215, 227, 288, 299 💬
31 Parkinson disease 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [16] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331 💬
32 Pathways of neurodegeneration - multiple diseases 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [16] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331 💬
33 Phospholipase D signaling pathway 💬
 [1] AVPR2 💬 D00291 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
34 Phospholipase D signaling pathway 💬
 [1] AVPR2 💬 D02235 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
35 Prion disease 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [16] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331 💬
36 Proteasome 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [16] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331 💬
37 Salivary secretion 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00680 💬 Methylergometrine [3] 118, 280, 288 💬
38 Salivary secretion 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08207 💬 Methylergometrine [3] 118, 280, 288 💬
39 Spinocerebellar ataxia 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [16] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331 💬
40 Staphylococcus aureus infection 💬
 [1] PLG 💬 D01136 💬 Tranexamic acid [6] 46, 70, 215, 227, 288, 299 💬
41 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 D00434 💬 Simvastatin [21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
42 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00680 💬 Methylergometrine [3] 118, 280, 288 💬
43 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08207 💬 Methylergometrine [3] 118, 280, 288 💬
44 Vasopressin-regulated water reabsorption 💬
 [1] AVPR2 💬 D00291 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
45 Vasopressin-regulated water reabsorption 💬
 [1] AVPR2 💬 D02235 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬

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