Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alcoholism 💬
 [1] DDC 💬 D00558 💬 Carbidopa [9]  2 ,  4 ,  6 , 13, 17, 90, 140, 164, 201 💬
2 Alcoholism 💬
 [2] DRD1, DRD2 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
3 Alcoholism 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
4 Alcoholism 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
5 Alcoholism 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
6 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
7 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
8 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
9 Amphetamine addiction 💬
 [1] DDC 💬 D00558 💬 Carbidopa [9]  2 ,  4 ,  6 , 13, 17, 90, 140, 164, 201 💬
10 Amphetamine addiction 💬
 [1] DRD1 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
11 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
12 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
13 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
14 Amyotrophic lateral sclerosis 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
15 Amyotrophic lateral sclerosis 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
16 Amyotrophic lateral sclerosis 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
17 Calcium signaling pathway 💬
 [2] DRD1, DRD5 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
18 Calcium signaling pathway 💬
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
19 Calcium signaling pathway 💬
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
20 Calcium signaling pathway 💬
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
21 cAMP signaling pathway 💬
 [3] DRD1, DRD2, DRD5 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
22 cAMP signaling pathway 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
23 cAMP signaling pathway 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
24 cAMP signaling pathway 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
25 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D00514 💬 Dexmedetomidine [13]  2 ,  4 ,  6 , 21, 34, 46, 70, 107, 113, 212, 215, 226, 280 💬
26 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D01205 💬 Dexmedetomidine [13]  2 ,  4 ,  6 , 21, 34, 46, 70, 107, 113, 212, 215, 226, 280 💬
27 Circadian entrainment 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
28 Circadian entrainment 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
29 Circadian entrainment 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
30 Cocaine addiction 💬
 [1] DDC 💬 D00558 💬 Carbidopa [9]  2 ,  4 ,  6 , 13, 17, 90, 140, 164, 201 💬
31 Cocaine addiction 💬
 [2] DRD1, DRD2 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
32 Cocaine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
33 Cocaine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
34 Cocaine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
35 Cortisol synthesis and secretion 💬
 [1] KCNA4 💬 D04127 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
36 Cushing syndrome 💬
 [1] KCNA4 💬 D04127 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
37 Dopaminergic synapse 💬
 [1] DDC 💬 D00558 💬 Carbidopa [9]  2 ,  4 ,  6 , 13, 17, 90, 140, 164, 201 💬
38 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
39 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
40 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
41 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
42 ECM-receptor interaction 💬
 [1] SV2A 💬 D00709 💬 Levetiracetam [5]  2 ,  4 ,  6 , 13, 307 💬
43 Gap junction 💬
 [2] DRD1, DRD2 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
44 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
45 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
46 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
47 Huntington disease 💬
 [2] GRIN1, GRIN2B 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
48 Huntington disease 💬
 [2] GRIN1, GRIN2B 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
49 Huntington disease 💬
 [2] GRIN1, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
50 Long-term potentiation 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
51 Long-term potentiation 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
52 Long-term potentiation 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
53 Metabolic pathways 💬
 [1] DDC 💬 D00558 💬 Carbidopa [9]  2 ,  4 ,  6 , 13, 17, 90, 140, 164, 201 💬
54 Morphine addiction 💬
 [1] DRD1 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
55 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D00514 💬 Dexmedetomidine [13]  2 ,  4 ,  6 , 21, 34, 46, 70, 107, 113, 212, 215, 226, 280 💬
56 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D01205 💬 Dexmedetomidine [13]  2 ,  4 ,  6 , 21, 34, 46, 70, 107, 113, 212, 215, 226, 280 💬
57 Neuroactive ligand-receptor interaction 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
58 Neuroactive ligand-receptor interaction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
59 Neuroactive ligand-receptor interaction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
60 Neuroactive ligand-receptor interaction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
61 Nicotine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
62 Nicotine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
63 Nicotine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
64 Parkinson disease 💬
 [2] DRD1, DRD2 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
65 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
66 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
67 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
68 Phenylalanine metabolism 💬
 [1] DDC 💬 D00558 💬 Carbidopa [9]  2 ,  4 ,  6 , 13, 17, 90, 140, 164, 201 💬
69 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
70 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
71 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
72 Rap1 signaling pathway 💬
 [1] DRD2 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
73 Rap1 signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
74 Rap1 signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
75 Rap1 signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
76 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
77 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
78 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
79 Serotonergic synapse 💬
 [1] DDC 💬 D00558 💬 Carbidopa [9]  2 ,  4 ,  6 , 13, 17, 90, 140, 164, 201 💬
80 Serotonergic synapse 💬
 [1] KCND2 💬 D04127 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
81 Spinocerebellar ataxia 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
82 Spinocerebellar ataxia 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
83 Spinocerebellar ataxia 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
84 Spinocerebellar ataxia 💬
 [2] KCNC3, KCND3 💬 D04127 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
85 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
86 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
87 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
88 Tryptophan metabolism 💬
 [1] DDC 💬 D00558 💬 Carbidopa [9]  2 ,  4 ,  6 , 13, 17, 90, 140, 164, 201 💬
89 Tyrosine metabolism 💬
 [1] DDC 💬 D00558 💬 Carbidopa [9]  2 ,  4 ,  6 , 13, 17, 90, 140, 164, 201 💬

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