Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
2 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
3 cAMP signaling pathway 💬
 [1] EDNRA 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
4 cAMP signaling pathway 💬
 [1] EDNRA 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
5 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
6 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
7 Complement and coagulation cascades 💬
 [1] SERPINC1 💬 D07510 💬 Heparin [12] 47, 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 💬
8 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [34]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
9 Cytokine-cytokine receptor interaction 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
10 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [34]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
11 Hematopoietic cell lineage 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
12 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [34]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
13 JAK-STAT signaling pathway 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
14 Melanogenesis 💬
 [1] EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
15 Melanogenesis 💬
 [1] EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
16 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
17 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
18 Neuroactive ligand-receptor interaction 💬
 [1] PTGIR 💬 D09994 💬 Selexipag [6] 47, 51, 70, 84, 86, 88 💬
19 Pathways in cancer 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [34]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
20 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
21 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
22 Pathways in cancer 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
23 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [34]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
24 PI3K-Akt signaling pathway 💬
 [1] EPOR 💬 D03231 💬 Erythropoietin [10]  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
25 Platelet activation 💬
 [1] PTGIR 💬 D09994 💬 Selexipag [6] 47, 51, 70, 84, 86, 88 💬
26 Relaxin signaling pathway 💬
 [1] EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
27 Relaxin signaling pathway 💬
 [1] EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
28 Renin secretion 💬
 [1] EDNRA 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
29 Renin secretion 💬
 [1] EDNRA 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
30 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
31 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
32 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 D09994 💬 Selexipag [6] 47, 51, 70, 84, 86, 88 💬

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