Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
2 Breast cancer 💬
 [2] ESR1, ESR2 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
3 cAMP signaling pathway 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
4 Chemical carcinogenesis - receptor activation 💬
 [3] AR, ESR1, ESR2 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
5 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
6 Cushing syndrome 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
7 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
8 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
9 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
10 GnRH secretion 💬
 [1] ESR2 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
11 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D02994 💬 Rituximab [49]  6 , 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
12 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
13 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00244 💬 Betamethasone [7]  2 , 28, 46, 83, 90, 96, 235 💬
14 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00972 💬 Betamethasone [7]  2 , 28, 46, 83, 90, 96, 235 💬
15 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01357 💬 Betamethasone [7]  2 , 28, 46, 83, 90, 96, 235 💬
16 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01402 💬 Betamethasone [7]  2 , 28, 46, 83, 90, 96, 235 💬
17 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01637 💬 Betamethasone [7]  2 , 28, 46, 83, 90, 96, 235 💬
18 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D02032 💬 Betamethasone [7]  2 , 28, 46, 83, 90, 96, 235 💬
19 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D02286 💬 Betamethasone [7]  2 , 28, 46, 83, 90, 96, 235 💬
20 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00088 💬 Hydrocortisone [11]  6 , 41, 46, 53, 75, 78, 81, 83, 97, 98, 299 💬
21 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00976 💬 Hydrocortisone cypionate [3]  6 , 81, 83 💬
22 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01442 💬 Hydrocortisone succinate [3]  6 , 81, 83 💬
23 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00407 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
24 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00751 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
25 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00979 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
26 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05000 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
27 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05001 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
28 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05002 💬 Methylprednisolone [48]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
29 Oocyte meiosis 💬
 [1] AR 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
30 Pathways in cancer 💬
 [3] AR, ESR1, ESR2 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
31 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
32 Prostate cancer 💬
 [1] AR 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
33 Proteoglycans in cancer 💬
 [1] ESR1 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
34 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬

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