Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Antifolate resistance 💬
 [2] DHFR, DHFR2 💬 D00142 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
2 Antifolate resistance 💬
 [2] DHFR, DHFR2 💬 D02115 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
3 Antifolate resistance 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
4 Antifolate resistance 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
5 Antifolate resistance 💬
 [1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
6 Antifolate resistance 💬
 [3] IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
7 Antifolate resistance 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
8 Antifolate resistance 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
9 Antifolate resistance 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
10 Antifolate resistance 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
11 Antifolate resistance 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
12 Antifolate resistance 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
13 Antifolate resistance 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
14 Antifolate resistance 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
15 Antifolate resistance 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
16 Antifolate resistance 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
17 Antifolate resistance 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
18 Antifolate resistance 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
19 Antifolate resistance 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
20 Antifolate resistance 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
21 Antifolate resistance 💬
 [1] TYMS 💬 D01223 💬 Capecitabine [1] 94 💬
22 Antifolate resistance 💬
 [1] TYMS 💬 D01244 💬 Tegafur [1] 46 💬