Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Inflammatory bowel disease 💬
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 💬 D04318 💬 Glatiramer [4]  2 , 13, 96, 156 💬
2 Inflammatory bowel disease 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [2] 49, 107 💬
3 Inflammatory bowel disease 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
4 Inflammatory bowel disease 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
5 Inflammatory bowel disease 💬
 [5] IL10, IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
6 Inflammatory bowel disease 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
7 Inflammatory bowel disease 💬
 [1] IL13 💬 D08857 💬 Anrukinzumab [1] 97 💬
8 Inflammatory bowel disease 💬
 [1] IL13 💬 D09633 💬 Lebrikizumab [1] 85 💬
9 Inflammatory bowel disease 💬
 [1] IL13 💬 D09979 💬 Tralokinumab [2] 85, 97 💬
10 Inflammatory bowel disease 💬
 [1] IL17A 💬 D10071 💬 Ixekizumab [6] 36, 37, 107, 162, 269, 271 💬
11 Inflammatory bowel disease 💬
 [1] IL17A 💬 D09967 💬 Secukinumab [8] 13, 37, 41, 46, 107, 160, 269, 271 💬
12 Inflammatory bowel disease 💬
 [1] IL17A 💬 D11127 💬 Tibulizumab [1] 53 💬
13 Inflammatory bowel disease 💬
 [2] IL17A, IL17F 💬 D11550 💬 Bimekizumab [3] 46, 97, 271 💬
14 Inflammatory bowel disease 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
15 Inflammatory bowel disease 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
16 Inflammatory bowel disease 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
17 Inflammatory bowel disease 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
18 Inflammatory bowel disease 💬
 [1] IL22 💬 D11953 💬 Efmarodocokin alfa [2] 96, 97 💬
19 Inflammatory bowel disease 💬
 [1] IL23A 💬 D10912 💬 Brazikumab [2] 96, 97 💬
20 Inflammatory bowel disease 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [5] 37, 41, 51, 96, 97 💬
21 Inflammatory bowel disease 💬
 [1] IL23A 💬 D11123 💬 Mirikizumab [3] 37, 96, 97 💬
22 Inflammatory bowel disease 💬
 [1] IL23A 💬 D11052 💬 Risankizumab [4] 37, 96, 97, 271 💬
23 Inflammatory bowel disease 💬
 [1] IL23A 💬 D10400 💬 Tildrakizumab [2] 162, 271 💬
24 Inflammatory bowel disease 💬
 [1] IL2RG 💬 D00748 💬 Aldesleukin [6]  2 , 35, 49, 65, 96, 97 💬
25 Inflammatory bowel disease 💬
 [1] IL4 💬 D03117 💬 Binetrakin [1] 46 💬
26 Inflammatory bowel disease 💬
 [1] IL4R 💬 D10354 💬 Dupilumab [4] 51, 98, 160, 162 💬
27 Inflammatory bowel disease 💬
 [1] IL5 💬 D04923 💬 Mepolizumab [4] 44, 45, 98, 162 💬
28 Inflammatory bowel disease 💬
 [1] IL5 💬 D08985 💬 Reslizumab [2] 44, 98 💬
29 Inflammatory bowel disease 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
30 Inflammatory bowel disease 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
31 Inflammatory bowel disease 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
32 Inflammatory bowel disease 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
33 Inflammatory bowel disease 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
34 Inflammatory bowel disease 💬
 [3] TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab [4] 51, 85, 222, 274 💬
35 Inflammatory bowel disease 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
36 Inflammatory bowel disease 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
37 Inflammatory bowel disease 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
38 Inflammatory bowel disease 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
39 Inflammatory bowel disease 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
40 Inflammatory bowel disease 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
41 Inflammatory bowel disease 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
42 Inflammatory bowel disease 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
43 Inflammatory bowel disease 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬