Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Apoptosis 💬
[1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
2 Apoptosis 💬
[1] CASP9 💬 D11195 💬 Rimiducid [6] 19, 60, 65, 284, 285, 326 💬
3 Apoptosis 💬
[1] CTSC 💬 D12120 💬 Brensocatib [1] 299 💬
4 Apoptosis 💬
[2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
5 Apoptosis 💬
[2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
6 Apoptosis 💬
[2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
7 Apoptosis 💬
[2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
8 Apoptosis 💬
[1] MAP3K5 💬 D10988 💬 Selonsertib [1] 86 💬
9 Apoptosis 💬
[1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
10 Apoptosis 💬
[1] NGF 💬 D09387 💬 Tanezumab [2] 226, 298 💬
11 Apoptosis 💬
[2] PARP1, PARP2 💬 D09730 💬 Olaparib [2] 86, 285 💬
12 Apoptosis 💬
[3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
13 Apoptosis 💬
[1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
14 Apoptosis 💬
[1] RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
15 Apoptosis 💬
[1] RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
16 Apoptosis 💬
[1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
17 Apoptosis 💬
[1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
18 Apoptosis 💬
[1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
19 Apoptosis 💬
[1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
20 Apoptosis 💬
[1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
21 Apoptosis 💬
[1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
22 Apoptosis 💬
[1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
23 Apoptosis 💬
[1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
24 Apoptosis 💬
[1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
25 Apoptosis 💬
[1] TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
26 Apoptosis 💬
[1] TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
27 Apoptosis 💬
[1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬