Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Cytosolic DNA-sensing pathway 💬
[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab [1] 49 💬
2 Cytosolic DNA-sensing pathway 💬
[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab [1] 49 💬
3 Cytosolic DNA-sensing pathway 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
4 Cytosolic DNA-sensing pathway 💬
[1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
5 Cytosolic DNA-sensing pathway 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
6 Cytosolic DNA-sensing pathway 💬
[2] IL1B, IL6 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
7 Cytosolic DNA-sensing pathway 💬
[1] IL6 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
8 Cytosolic DNA-sensing pathway 💬
[1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
9 Cytosolic DNA-sensing pathway 💬
[1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
10 Cytosolic DNA-sensing pathway 💬
[1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
11 Cytosolic DNA-sensing pathway 💬
[1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬