Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Rheumatoid arthritis 💬
 [5] CCL2, IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
2 Rheumatoid arthritis 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
3 Rheumatoid arthritis 💬
 [2] CD80, CD86 💬 D03222 💬 Belatacept [1] 46 💬
4 Rheumatoid arthritis 💬
 [2] CSF1, FLT1 💬 D06402 💬 Sunitinib [2] 28, 34 💬
5 Rheumatoid arthritis 💬
 [2] CSF1, FLT1 💬 D08552 💬 Sunitinib [2] 28, 34 💬
6 Rheumatoid arthritis 💬
 [1] CSF2 💬 D11343 💬 Otilimab [2] 46, 256 💬
7 Rheumatoid arthritis 💬
 [1] CTLA4 💬 D04603 💬 Ipilimumab [1] 159 💬
8 Rheumatoid arthritis 💬
 [1] CTLA4 💬 D06657 💬 Tremelimumab [1] 96 💬
9 Rheumatoid arthritis 💬
 [1] FLT1 💬 D03218 💬 Axitinib [1] 34 💬
10 Rheumatoid arthritis 💬
 [1] FLT1 💬 D08881 💬 Cediranib [1] 34 💬
11 Rheumatoid arthritis 💬
 [1] FLT1 💬 D10481 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
12 Rheumatoid arthritis 💬
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 💬 D04318 💬 Glatiramer [4]  2 , 13, 96, 156 💬
13 Rheumatoid arthritis 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [2] 49, 107 💬
14 Rheumatoid arthritis 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
15 Rheumatoid arthritis 💬
 [1] IL17A 💬 D11550 💬 Bimekizumab [3] 46, 97, 271 💬
16 Rheumatoid arthritis 💬
 [1] IL17A 💬 D10071 💬 Ixekizumab [6] 36, 37, 107, 162, 269, 271 💬
17 Rheumatoid arthritis 💬
 [1] IL17A 💬 D09967 💬 Secukinumab [8] 13, 37, 41, 46, 107, 160, 269, 271 💬
18 Rheumatoid arthritis 💬
 [2] IL17A, TNFSF13B 💬 D11127 💬 Tibulizumab [1] 53 💬
19 Rheumatoid arthritis 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
20 Rheumatoid arthritis 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
21 Rheumatoid arthritis 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
22 Rheumatoid arthritis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
23 Rheumatoid arthritis 💬
 [1] IL23A 💬 D10912 💬 Brazikumab [2] 96, 97 💬
24 Rheumatoid arthritis 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [5] 37, 41, 51, 96, 97 💬
25 Rheumatoid arthritis 💬
 [1] IL23A 💬 D11123 💬 Mirikizumab [3] 37, 96, 97 💬
26 Rheumatoid arthritis 💬
 [1] IL23A 💬 D11052 💬 Risankizumab [4] 37, 96, 97, 271 💬
27 Rheumatoid arthritis 💬
 [1] IL23A 💬 D10400 💬 Tildrakizumab [2] 162, 271 💬
28 Rheumatoid arthritis 💬
 [1] IL23A 💬 D09214 💬 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
29 Rheumatoid arthritis 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
30 Rheumatoid arthritis 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
31 Rheumatoid arthritis 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
32 Rheumatoid arthritis 💬
 [1] ITGAL 💬 D03959 💬 Efalizumab [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
33 Rheumatoid arthritis 💬
 [1] LTB 💬 D08866 💬 Baminercept [4] 13, 46, 53, 97 💬
34 Rheumatoid arthritis 💬
 [3] TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab [4] 51, 85, 222, 274 💬
35 Rheumatoid arthritis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
36 Rheumatoid arthritis 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
37 Rheumatoid arthritis 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
38 Rheumatoid arthritis 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
39 Rheumatoid arthritis 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
40 Rheumatoid arthritis 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
41 Rheumatoid arthritis 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
42 Rheumatoid arthritis 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
43 Rheumatoid arthritis 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
44 Rheumatoid arthritis 💬
 [1] TNFSF11 💬 D03684 💬 Denosumab [7] 46, 50, 93, 95, 96, 274, 299 💬
45 Rheumatoid arthritis 💬
 [2] TNFSF13, TNFSF13B 💬 D09704 💬 Atacicept [4] 13, 46, 49, 66 💬
46 Rheumatoid arthritis 💬
 [1] TNFSF13B 💬 D03068 💬 Belimumab [12] 11, 13, 43, 44, 46, 49, 51, 53, 66, 222, 296, 300 💬
47 Rheumatoid arthritis 💬
 [1] TNFSF13B 💬 D10083 💬 Tabalumab [2] 46, 49 💬
48 Rheumatoid arthritis 💬
 [1] VEGFA 💬 D09574 💬 Aflibercept [2] 90, 166 💬
49 Rheumatoid arthritis 💬
 [1] VEGFA 💬 D06409 💬 Bevacizumab [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
50 Rheumatoid arthritis 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬