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 Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト) 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"    Synonyms (Drugs) were also searched for.

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40 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY
 On map, Yellow: Drug target, Red: Disease-related 
 KEGG GENES  KEGG DRUG  DrugBank   指定難病告示番号
 1  Adipocytokine signaling pathway 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 2  Alanine, aspartate and glutamate metabolism 
 4 genes, 1 drug (DrugBank) and 14 diseases shown 
 4件: ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 3  Aldosterone synthesis and secretion 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 4  AMPK signaling pathway 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 5  Apelin signaling pathway 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 6  Autophagy - animal 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 7  beta-Alanine metabolism 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 
 3件: ABAT, GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 8  Butanoate metabolism 
 4 genes, 1 drug (DrugBank) and 14 diseases shown 
 4件: ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 9  Calcium signaling pathway 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 10  cAMP signaling pathway 
 1 gene, 1 drug (DrugBank) and 3 diseases shown 
 1件: GLP1R   D04121   Exenatide   3件: 6, 193, 233 
 11  Circadian entrainment 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 12  Circadian rhythm 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 13  Cortisol synthesis and secretion 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 14  Cushing syndrome 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 15  Fluid shear stress and atherosclerosis 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 16  FoxO signaling pathway 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 17  GABAergic synapse 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 
 3件: ABAT, GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 18  Glucagon signaling pathway 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 19  GnRH secretion 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 20  Hypertrophic cardiomyopathy (HCM) 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 21  Insulin resistance 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 22  Insulin secretion 
 1 gene, 1 drug (DrugBank) and 3 diseases shown 
 1件: GLP1R   D04121   Exenatide   3件: 6, 193, 233 
 23  Insulin signaling pathway 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 24  Longevity regulating pathway 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 25  Longevity regulating pathway - multiple species 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 26  MAPK signaling pathway 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 27  Metabolic pathways 
 4 genes, 1 drug (DrugBank) and 14 diseases shown 
 4件: ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 28  mTOR signaling pathway 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 29  Neuroactive ligand-receptor interaction 
 1 gene, 1 drug (DrugBank) and 3 diseases shown 
 1件: GLP1R   D04121   Exenatide   3件: 6, 193, 233 
 30  Non-alcoholic fatty liver disease (NAFLD) 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 31  Oxytocin signaling pathway 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 32  PI3K-Akt signaling pathway 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 33  Propanoate metabolism 
 1 gene, 1 drug (DrugBank) and 14 diseases shown 
 1件: ABAT   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 34  Protein digestion and absorption 
 1 gene, 1 drug (DrugBank) and 3 diseases shown 
 1件: DPP4   D08516   Sitagliptin   3件: 75, 233, 299 
 35  Taurine and hypotaurine metabolism 
 2 genes, 1 drug (DrugBank) and 14 diseases shown 
 2件: GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 36  Thermogenesis 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 37  Tight junction 
 2 genes, 1 drug (DrugBank) and 17 diseases shown 
 2件: PRKAA1, PRKAA2   D00944   Metformin   17件: 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 38  Type I diabetes mellitus 
 2 genes, 1 drug (DrugBank) and 14 diseases shown 
 2件: GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 39  Type II diabetes mellitus 
 1 gene, 1 drug (DrugBank) and 14 diseases shown 
 1件: CACNA1G   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 40  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank) and 14 diseases shown 
 1件: ABAT   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 

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