Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Cytokine-cytokine receptor interaction 💬
1件: ACVR2A 💬 D09670 💬 Sotatercept 2件: 86, 284 💬
2 Cytokine-cytokine receptor interaction 💬
2件: ACVR2A, ACVR2B 💬 D10620 💬 Bimagrumab 1件: 15 💬
3 Cytokine-cytokine receptor interaction 💬
1件: BMPR2 💬 D03779 💬 Dibotermin alfa 1件: 34 💬
4 Cytokine-cytokine receptor interaction 💬
6件: CCL2, IL10, IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
5 Cytokine-cytokine receptor interaction 💬
2件: CCR2, CCR5 💬 D09878 💬 Cenicriviroc 1件: 94 💬
6 Cytokine-cytokine receptor interaction 💬
1件: CCR4 💬 D09761 💬 Mogamulizumab 1件: 26 💬
7 Cytokine-cytokine receptor interaction 💬
1件: CCR5 💬 D06670 💬 Maraviroc 2件: 46, 84 💬
8 Cytokine-cytokine receptor interaction 💬
1件: CD40 💬 D11357 💬 Bleselumab 1件: 222 💬
9 Cytokine-cytokine receptor interaction 💬
1件: CD40 💬 D11610 💬 Iscalimab 2件: 49, 53 💬
10 Cytokine-cytokine receptor interaction 💬
1件: CD40 💬 D11597 💬 Ravagalimab 2件: 53, 97 💬
11 Cytokine-cytokine receptor interaction 💬
1件: CD40LG 💬 D06193 💬 Toralizumab 1件: 63 💬
12 Cytokine-cytokine receptor interaction 💬
1件: CSF1 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
13 Cytokine-cytokine receptor interaction 💬
1件: CSF1 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
14 Cytokine-cytokine receptor interaction 💬
1件: CSF1R 💬 D11270 💬 Pexidartinib 1件: 34 💬
15 Cytokine-cytokine receptor interaction 💬
1件: CSF2 💬 D11343 💬 Otilimab 2件: 46, 256 💬
16 Cytokine-cytokine receptor interaction 💬
1件: CSF2RA 💬 D09930 💬 Mavrilimumab 2件: 41, 46 💬
17 Cytokine-cytokine receptor interaction 💬
1件: CSF2RA 💬 D05066 💬 Molgramostim 3件: 97, 229, 299 💬
18 Cytokine-cytokine receptor interaction 💬
1件: CSF2RA 💬 D05712 💬 Regramostim 1件: 229 💬
19 Cytokine-cytokine receptor interaction 💬
1件: CSF2RA 💬 D05803 💬 Sargramostim 7件:  6 , 28, 60, 62, 96, 229, 285 💬
20 Cytokine-cytokine receptor interaction 💬
1件: CSF3R 💬 D03235 💬 Filgrastim 34件:  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
21 Cytokine-cytokine receptor interaction 💬
1件: CSF3R 💬 D03247 💬 Lenograstim 7件:  2 , 13, 16, 18, 19, 57, 65 💬
22 Cytokine-cytokine receptor interaction 💬
1件: CSF3R 💬 D06889 💬 Pegfilgrastim 1件: 60 💬
23 Cytokine-cytokine receptor interaction 💬
2件: CXCR1, CXCR2 💬 D08984 💬 Reparixin 2件: 298, 299 💬
24 Cytokine-cytokine receptor interaction 💬
1件: CXCR4 💬 D08971 💬 Plerixafor 6件: 19, 20, 51, 65, 285, 299 💬
25 Cytokine-cytokine receptor interaction 💬
1件: EPOR 💬 D03231 💬 Erythropoietin 10件:  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
26 Cytokine-cytokine receptor interaction 💬
1件: EPOR 💬 D09946 💬 Peginesatide 1件: 283 💬
27 Cytokine-cytokine receptor interaction 💬
1件: GHR 💬 D11486 💬 Lonapegsomatropin 1件: 78 💬
28 Cytokine-cytokine receptor interaction 💬
1件: GHR 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
29 Cytokine-cytokine receptor interaction 💬
1件: GHR 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
30 Cytokine-cytokine receptor interaction 💬
1件: GHR 💬 D05394 💬 Pegvisomant 1件: 78 💬
31 Cytokine-cytokine receptor interaction 💬
1件: GHR 💬 D11194 💬 Somapacitan 1件: 78 💬
32 Cytokine-cytokine receptor interaction 💬
1件: GHR 💬 D02691 💬 Somatotropin 23件:  2 ,  3 , 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299 💬
33 Cytokine-cytokine receptor interaction 💬
1件: GHR 💬 D11193 💬 Somavaratan 1件: 78 💬
34 Cytokine-cytokine receptor interaction 💬
13件: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab 1件: 49 💬
35 Cytokine-cytokine receptor interaction 💬
13件: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab 1件: 49 💬
36 Cytokine-cytokine receptor interaction 💬
2件: IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab 2件: 46, 49 💬
37 Cytokine-cytokine receptor interaction 💬
2件: IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa 6件: 13, 25, 26, 28, 56, 96 💬
38 Cytokine-cytokine receptor interaction 💬
2件: IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a 1件: 56 💬
39 Cytokine-cytokine receptor interaction 💬
2件: IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b 2件: 25, 34 💬
40 Cytokine-cytokine receptor interaction 💬
2件: IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a 4件: 13, 26, 96, 97 💬
41 Cytokine-cytokine receptor interaction 💬
2件: IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b 1件: 13 💬
42 Cytokine-cytokine receptor interaction 💬
2件: IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a 1件: 13 💬
43 Cytokine-cytokine receptor interaction 💬
1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
44 Cytokine-cytokine receptor interaction 💬
1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
45 Cytokine-cytokine receptor interaction 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
46 Cytokine-cytokine receptor interaction 💬
1件: IL11RA 💬 D05266 💬 Oprelvekin 2件: 96, 288 💬
47 Cytokine-cytokine receptor interaction 💬
3件: IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
48 Cytokine-cytokine receptor interaction 💬
1件: IL13 💬 D08857 💬 Anrukinzumab 1件: 97 💬
49 Cytokine-cytokine receptor interaction 💬
1件: IL13 💬 D09633 💬 Lebrikizumab 1件: 85 💬
50 Cytokine-cytokine receptor interaction 💬
1件: IL13 💬 D09979 💬 Tralokinumab 2件: 85, 97 💬
51 Cytokine-cytokine receptor interaction 💬
1件: IL17A 💬 D10071 💬 Ixekizumab 6件: 36, 37, 107, 162, 269, 271 💬
52 Cytokine-cytokine receptor interaction 💬
1件: IL17A 💬 D09967 💬 Secukinumab 8件: 13, 37, 41, 46, 107, 160, 269, 271 💬
53 Cytokine-cytokine receptor interaction 💬
2件: IL17A, IL17F 💬 D11550 💬 Bimekizumab 3件: 46, 97, 271 💬
54 Cytokine-cytokine receptor interaction 💬
2件: IL17A, TNFSF13B 💬 D11127 💬 Tibulizumab 1件: 53 💬
55 Cytokine-cytokine receptor interaction 💬
1件: IL17RA 💬 D10061 💬 Brodalumab 2件: 37, 51 💬
56 Cytokine-cytokine receptor interaction 💬
1件: IL1A 💬 D11253 💬 Bermekimab 1件: 51 💬
57 Cytokine-cytokine receptor interaction 💬
2件: IL1A, IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
58 Cytokine-cytokine receptor interaction 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
59 Cytokine-cytokine receptor interaction 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
60 Cytokine-cytokine receptor interaction 💬
2件: IL1R1, IL1R2 💬 D02934 💬 Anakinra 19件:  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
61 Cytokine-cytokine receptor interaction 💬
1件: IL1RL2 💬 D12066 💬 Spesolimab 3件: 37, 96, 97 💬
62 Cytokine-cytokine receptor interaction 💬
1件: IL20 💬 D11756 💬 Fletikumab 1件: 46 💬
63 Cytokine-cytokine receptor interaction 💬
1件: IL22 💬 D11953 💬 Efmarodocokin alfa 2件: 96, 97 💬
64 Cytokine-cytokine receptor interaction 💬
1件: IL23A 💬 D10912 💬 Brazikumab 2件: 96, 97 💬
65 Cytokine-cytokine receptor interaction 💬
1件: IL23A 💬 D10438 💬 Guselkumab 5件: 37, 41, 51, 96, 97 💬
66 Cytokine-cytokine receptor interaction 💬
1件: IL23A 💬 D11123 💬 Mirikizumab 3件: 37, 96, 97 💬
67 Cytokine-cytokine receptor interaction 💬
1件: IL23A 💬 D11052 💬 Risankizumab 4件: 37, 96, 97, 271 💬
68 Cytokine-cytokine receptor interaction 💬
1件: IL23A 💬 D10400 💬 Tildrakizumab 2件: 162, 271 💬
69 Cytokine-cytokine receptor interaction 💬
1件: IL2RA 💬 D03058 💬 Basiliximab 6件:  2 , 50, 66, 97, 222, 228 💬
70 Cytokine-cytokine receptor interaction 💬
1件: IL2RA 💬 D03639 💬 Daclizumab 8件: 13, 56, 60, 65, 97, 107, 283, 284 💬
71 Cytokine-cytokine receptor interaction 💬
3件: IL2RA, IL2RB, IL2RG 💬 D00748 💬 Aldesleukin 6件:  2 , 35, 49, 65, 96, 97 💬
72 Cytokine-cytokine receptor interaction 💬
1件: IL31RA 💬 D11080 💬 Nemolizumab 1件: 51 💬
73 Cytokine-cytokine receptor interaction 💬
1件: IL4 💬 D03117 💬 Binetrakin 1件: 46 💬
74 Cytokine-cytokine receptor interaction 💬
1件: IL4R 💬 D10354 💬 Dupilumab 4件: 51, 98, 160, 162 💬
75 Cytokine-cytokine receptor interaction 💬
1件: IL5 💬 D04923 💬 Mepolizumab 4件: 44, 45, 98, 162 💬
76 Cytokine-cytokine receptor interaction 💬
1件: IL5 💬 D08985 💬 Reslizumab 2件: 44, 98 💬
77 Cytokine-cytokine receptor interaction 💬
1件: IL5RA 💬 D09874 💬 Benralizumab 5件: 44, 45, 98, 162, 299 💬
78 Cytokine-cytokine receptor interaction 💬
1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
79 Cytokine-cytokine receptor interaction 💬
1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
80 Cytokine-cytokine receptor interaction 💬
2件: IL6, TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
81 Cytokine-cytokine receptor interaction 💬
1件: IL6R 💬 D10161 💬 Sarilumab 5件: 41, 46, 84, 107, 271 💬
82 Cytokine-cytokine receptor interaction 💬
1件: IL6R 💬 D11079 💬 Satralizumab 2件: 11, 13 💬
83 Cytokine-cytokine receptor interaction 💬
1件: IL6R 💬 D02596 💬 Tocilizumab 21件:  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
84 Cytokine-cytokine receptor interaction 💬
1件: LEPR 💬 D05014 💬 Metreleptin 1件: 265 💬
85 Cytokine-cytokine receptor interaction 💬
1件: LTA 💬 D10187 💬 Pateclizumab 1件: 46 💬
86 Cytokine-cytokine receptor interaction 💬
2件: LTA, TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
87 Cytokine-cytokine receptor interaction 💬
1件: LTB 💬 D08866 💬 Baminercept 4件: 13, 46, 53, 97 💬
88 Cytokine-cytokine receptor interaction 💬
1件: MPL 💬 D10306 💬 Avatrombopag 2件: 60, 63 💬
89 Cytokine-cytokine receptor interaction 💬
1件: MPL 💬 D08990 💬 Romiplostim 4件: 60, 63, 64, 65 💬
90 Cytokine-cytokine receptor interaction 💬
1件: MSTN 💬 D11797 💬 Apitegromab 1件:  3  💬
91 Cytokine-cytokine receptor interaction 💬
1件: MSTN 💬 D11047 💬 Domagrozumab 1件: 113 💬
92 Cytokine-cytokine receptor interaction 💬
1件: NGF 💬 D09387 💬 Tanezumab 2件: 226, 298 💬
93 Cytokine-cytokine receptor interaction 💬
1件: NGFR 💬 D11028 💬 Cenegermin 2件: 53, 90 💬
94 Cytokine-cytokine receptor interaction 💬
1件: PRL 💬 D00780 💬 Bromocriptine 2件:  6 , 74 💬
95 Cytokine-cytokine receptor interaction 💬
1件: PRL 💬 D03165 💬 Bromocriptine 2件:  6 , 74 💬
96 Cytokine-cytokine receptor interaction 💬
1件: PRL 💬 D00987 💬 Cabergoline 3件:  6 , 74, 75 💬
97 Cytokine-cytokine receptor interaction 💬
1件: PRL 💬 D01348 💬 Terguride 2件: 51, 86 💬
98 Cytokine-cytokine receptor interaction 💬
3件: TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
99 Cytokine-cytokine receptor interaction 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
100 Cytokine-cytokine receptor interaction 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
101 Cytokine-cytokine receptor interaction 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
102 Cytokine-cytokine receptor interaction 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
103 Cytokine-cytokine receptor interaction 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
104 Cytokine-cytokine receptor interaction 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
105 Cytokine-cytokine receptor interaction 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
106 Cytokine-cytokine receptor interaction 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
107 Cytokine-cytokine receptor interaction 💬
1件: TNFRSF13C 💬 D12151 💬 Ianalumab 5件: 35, 46, 49, 53, 95 💬
108 Cytokine-cytokine receptor interaction 💬
1件: TNFRSF17 💬 D11595 💬 Belantamab mafodotin 1件: 28 💬
109 Cytokine-cytokine receptor interaction 💬
1件: TNFRSF8 💬 D09587 💬 Brentuximab vedotin 2件: 49, 51 💬
110 Cytokine-cytokine receptor interaction 💬
1件: TNFSF11 💬 D03684 💬 Denosumab 7件: 46, 50, 93, 95, 96, 274, 299 💬
111 Cytokine-cytokine receptor interaction 💬
2件: TNFSF13, TNFSF13B 💬 D09704 💬 Atacicept 4件: 13, 46, 49, 66 💬
112 Cytokine-cytokine receptor interaction 💬
1件: TNFSF13B 💬 D03068 💬 Belimumab 12件: 11, 13, 43, 44, 46, 49, 51, 53, 66, 222, 296, 300 💬
113 Cytokine-cytokine receptor interaction 💬
1件: TNFSF13B 💬 D10083 💬 Tabalumab 2件: 46, 49 💬