Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 IL6 51件: EGFR tyrosine kinase inhibitor resistance 💬, Antifolate resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, PI3K-Akt signaling pathway 💬, Cellular senescence 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Intestinal immune network for IgA production 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Lipid and atherosclerosis 💬 D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
2 IL6 51件: EGFR tyrosine kinase inhibitor resistance 💬, Antifolate resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, PI3K-Akt signaling pathway 💬, Cellular senescence 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Intestinal immune network for IgA production 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Lipid and atherosclerosis 💬 D08976 Pomalidomide 6件: 28, 34, 51, 85, 227, 331
3 IL6 51件: EGFR tyrosine kinase inhibitor resistance 💬, Antifolate resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, PI3K-Akt signaling pathway 💬, Cellular senescence 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Intestinal immune network for IgA production 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Lipid and atherosclerosis 💬 D09669 Siltuximab 2件: 28, 331
4 IL6 51件: EGFR tyrosine kinase inhibitor resistance 💬, Antifolate resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, PI3K-Akt signaling pathway 💬, Cellular senescence 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Intestinal immune network for IgA production 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Lipid and atherosclerosis 💬 D10080 Sirukumab 2件: 41, 46